Online ISSN: 2515-8260

Keywords : Acute liver injury

Acute liver injuryin COVID-19 infection: Report from Field hospital and COVID-19 situation update in Association of Southeast Asian Nations (ASEAN)

Sarita Ratana- Amornpin, MD; Ratha‐ kornVilaichone. MD, Ph.D.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 1213-1227

Introduction: Emergence of the novel severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) has affectedalmost every country. This study aimed to provide the patterns of acute liver injuryof COVID-19 infection from field hospital in Thailand and ASEAN and update situation of COVID-19 infection in ASEAN.
Method: All patients diagnosed with COVID-19 and admitted toThammasatuniversity field hospital between January 2020 and May 2020 were included.ASEAN COVID-19 studies have beensearched by PubMed and Scopus and extensively reviewed.
Results:There were 381 ASEAN COVID-19 studies searched by PubMed and Scopus. However, 3 studies reported the liver function tests and met our inclusion criteria. Total of 86 patients (52 patients form Thailand, 18 patients from Indonesia and 16 patients from Singapore) were included and described liver parameters of COVID-19 infection in ASEAN. From our field hospital, total of 412 COVID-19 tests performed and 41 patients were confirmed SARS-CoV-2 infection.The abnormal liver function test was detected in 52.6%.The patterns of acute liver injury in COVID-19 patients were transaminitis (36.8%) and hypoalbuminemia (31.6%)whichsignificantly associated with severe COVID-19 infection (OR 14.50, 95%CI 1.14-185.18, p=0.040; OR 31.49, 95%CI 1.41-705.47, p=0.030; respectively). 
Conclusions:Acute liver injury could be found in COVID-19 infectionespecially in ASEAN. COVID-19 patients with transaminitis and hypoalbuminemia should raise clinical suspicion for severe disease andbe closely monitoredfor rapid disease progression.