Online ISSN: 2515-8260

Keywords : Hypothyroidism


Effect of Maternal Hypothyroidism During Gestation and Lactation in Female Rats on Thyroidal and Testicular Functions of Their Male Offspring at Puberty

Sarah J. S .; Jassim M. A. Alkalby

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1890-1900

Maternal hypothyroidism, is a deficiency of the transfer of thyroid hormones from the mother to the
fetus. This study was designed to investigate the effect of induced hypothyroidism in female rats during
gestation (G), lactation (L) and gestation and lactation (G+L) on thyroid and testicular functions of
their male offspring at puberty. The hypothyroidism state was induced by administration of
propylthiouracil (PTU) (0.2) mg/kg b.w/day orally to three pregnant female rats’ groups during
different physiological state as follows: gestational group (treated from day 6 till parturition),
lactational group ( treated from parturition till weaning) and gestational and lactational (treated from
day 6 of parturition till weaning), in addition, to pregnant control group which received distilled water
(D.W) only. All offspring were weaned at 30 days age and six male offspring of each group were
chosen randomly and left without treatment until puberty (60 days) postnatal. Blood samples were
collected to the measurement of serum level of some hormones including thyroid stimulating hormone
(TSH), thyroxin (T4), triidothyronine (T3), testosterone (T), luteinizing hormone (LH), and folliclestimulating
hormone (FSH). Thyroid glands and testes were removed for histopathology study. The
results of hormonal analysis revealed a significant (P≤0.05) increase of TSH concentration in G and L
groups and a significant (P≤0.05) decrease of T4 in all treatment groups while a significant decrease in
T3 was recorded in the G group compared with the control group. Histopathological results showed
histological changes in both thyroid glands and testes in G, L, and G+L groups. The present study
concluded that the different maternal hypothyroidism periods have a nearly different impacts on
offspring male rat, where the G group was the most affected than others.

Effects of Infection with Toxoplasma Gondii to the Levels of Thyroid Hormones

Taghreed Ahmed Mustafa Al-Issawi; Aysir Saleh Mohammed

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 110-114

The present study was designed to detect the effect of toxoplasmosis in the thyroid hormones level Samples were collected during the period from July2019 to January 2020. Where the separated serum was preserved at a temperature (-20) until use. The enzyme-linked immunosorbent technique (ELISA) was used to detect toxoplasmosis. Hormone levels (TSH, TSH, T3 and calcitonin) were also measured using ELISA technology, Hormonal study, the results of the current study showed significant increase (P