Online ISSN: 2515-8260

Keywords : Labetalol


A study on heart rate and side effects between esmolol and labetalol during tracheal extubation

Dr. Shilpa Omkarappa, Dr. Amitha S, Dr.K.V. Edvine

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 639-645

Electrophysiological studies revealed that Esmolol causes an increase in sinus cycle length
and sinus node recovery time. Electrocardiographic parameters like 'PR' 'QRS' and 'QT'
intervals were not prolonged. In contrast to other beta blockers, electrophysiological values
return to baseline values within a period of 30 minutes after withdrawing the drug. When
infused at a dose of 200 micrograms/kg/minute, Esmolol can significantly reduce the namely,
resting heart rate, Systolic blood pressure, rate pressure product, cardiac index. Esmolol can
also attenuate isoprenaline induced tachycardia. After obtaining clearance from the
Institutional Ethical Committee and informed written consent, a prospective randomized
double-blinded study was conducted on sixty patients scheduled for various elective surgical
procedures belonging to patients physical status American Society of Anesthesiologists
(ASA) Classes I and II were included in the study. In esmolol group the basal heart rate was
97.8bpm. During reversal heart rate increased to 102.7bpm. During drug injection and
subsequently heart rate decreased as shown in table. At 15min post extubation heart rate was
84.6bpm which was less than basal.
In labetalol group the basal heart rate was 97.5bpm. During reversal heart rate increased to
103.1bpm. During drug injection and subsequently heart rate decreased as shown in table. At
15min post extubation heart rate was 69.9bpm which was much less than basal.

Blood pressure response to tracheal extubation: Comparative study between esmolol and labetalol

Dr. Amitha S, Dr. Shilpa Omkarappa, Dr.K.V. Edvine

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 646-652

Complications after trachea extubation are three times more common than complications occurring
during tracheal intubation and induction of anaesthesia. Hypertension and tachycardia are well
documented events during extubation. These hemodynamic responses reflects sympatho-adrenal reflex
stimulation (epipharyngeal and laryngo pharyngeal stimulation) with concomitant increase in plasma
level of catecholamines and activation of alpha and beta adrenergic receptors. A routine preanesthetic
examination was conducted assessing the general condition of the patients on the evening before
surgery. From all patients, informed consent was obtained. All patients were kept nil per oral for 8 h.
On arrival in the operating room, i.v. line was established, and fluid dextrose with normal saline was
started. Patients were connected to multichannel monitor which records HR, noninvasive blood
pressure, end-tidal carbon dioxide, and oxygen saturation. Statistical evaluation between the group
showed there was no significance of SBP between the group at basal, extubation upto 1th minute post
extubation (p>0.05). At 2th min (p=0.034), 3rd min (p-0.023) and 15th min (p=0.024) post extubation
there was significance esmolol> labetalol at 2nd and 3rd, labetalol >esmolol at 15th min.

A COMPARATIVE STUDY OF LABETALOL AND NIFEDIPINE IN THE MANAGEMENT OF HYPERTENSIVE DISORDERS OF PREGNANCY

Akaraonye, Mercy. A, Confesora Valdez Aquino, Chinelo Igweike, Adaugo Nwanguma, Ayesha Fonseca, Luwaji Aderinmola, Oluwaseun Christiannah Konigbagbe, Srinidhi Cheeti

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2327-2333

Background: Hypertensive disorders of pregnancy are one of the major causes of morbidity and mortality in both the mother and fetus. The present study was conducted to compare labetalol and nifedipine in the management of hypertensive disorders during pregnancy.
Materials & Methods: 72 pregnant between the ages of with hypertension were divided into two groups Was this a blind study? Oral Labetalol was initially started at a dose of 100 mg twice daily (BD) and a maximum dose of 200 mg thrice daily (TDS) was given. Oral What type of Nifedipine? XR, regular? was initially started with a dose of 10 mg BD and titrated upwards to 20 mg TDS.  Pregnant subjects were monitored daily for blood pressure and fetal well- being.    
Results: Group I received 100 mg labetalol and group II received 10 mg Nifedipine. Gravida I patients were noted to have 62% and 60%, Gravida 2, 24% and 27%, and Gravida 3 14% and 13% reduction in group I and group II respectively. The difference was significant (P< 0.05). SBP (mm Hg) before treatment was 153.4 and 152.4 and after treatment was 126.8 and 138.2 in group I and group II respectively. DBP (mm Hg) before treatment was 104.2 and 106.4 and after treatment was 90.5 and 99.2. MAP (mm Hg) before treatment was 120.2 and 122.6 and after treatment was 101.5 and 112.8 in group I and group II respectively. The difference was significant (P< 0.05).
Conclusion: Labetalol proved to be a better antihypertensive than nifedipine in controlling maternal hypertension and fetal outcome. This effect was significant in systolic blood pressure control compared to diastolic blood pressure control ( p < .05) and (p <.12). This difference was also remarkable in terms of parity as shown in the chart comparing Gravida 1, 2 & 3.

ORAL NIFEDIPINE VERSUS ORAL LABETALOL IN THE TREATMENT OF PREGNANCY INDUCED HYPERTENSION

R.P. Patange; Archna V. Rokadhe; Ghori R. Shinde; Sanjay N. Jadhav; Ashitosh Bahulekar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4136-4141

This study was undertaken to determine the effectiveness of two anti-hypertensive drugs: oral Nifedipine and oral Labetalol in cases of extreme preeclampsia in terms of their side effect profile, BP regulation, time taken to lower BP, and number of doses required. The objective of the study was to calculate the time required to reduce the blood pressure to the target level of 90 / 100 mmHg diastolic and less than 160mmHg systolic.In the labetalol group the mean SBP before treatment was 158mm of Hg which was reduced to 140 mm of Hg. The decline rate in the labetalol group was 11.77%. This study proved that labetalol reduces the BP more effectively than nifedipine and also has minimal side effects with less frequent dosing schedule as compared to nifedipine thus indicating that labetalol is better than nifedipine in lowering the BP in cases of preeclampsia.