Online ISSN: 2515-8260

Keywords : Nephropathy

Detection of early nephropathy in type II diabetic patient by using kim-1 as a biomarker: A prospective study

Dr. Khushant Jangid, Dr. Archana Dubey, Gunvi Ohari, Dr. Ashok Kumar Kachhawah

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1487-1491

Background: The present study aimed to investigate the clinical significance of urinary Kim-1 level in type II diabetic patients with and without nephropathy and to evaluate its relation to various clinical and laboratory parameters as an early predictor of diabetic nephropathy.
Methodology: The prospective study was conducted at Department of Medicine at Dr M.D.M. Hospital, Jodhpur. Attached to Dr. S.N. Medical College to study the detection of Kidney injury molecule-1 (Kim-1): An early biomarker for nephropathy in type II diabetic patients attending the Medicine Outdoor and Indoor at M.D.M. Hospital, Jodhpur. It includes 75 patients whose serum creatinine level was less than 1.5mg/dL. Diabetes was defined as fasting plasma glucose ≥126 mg/dL according to WHO criteria.
Results: Kim-1 is found raised in 68% patients and with normal albuminuria and microalbuminuria also significantly correlated with other variables i.e. fasting blood sugar, HbA1c p value is less than 0.001 for all these variables. So kim-1 can be used to diagnosis early nephropathy as a sensitive, rapid, noninvasive test in diabetes. With these we conclude KIM-1 is a good for early detection of Diabetic nephropathy and it is nicely correlating with urinary microalbumin level which is gold standard for detection of early nephropathy.

Pulse Pressure and Diurnal Blood Pressure Variation Associated with Micro- and Macrovascular Complications in Type 2 Diabetes

Abhishek Kumar Verma, Abhishek Kumar, Anurag Vyas, Vikki .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 6112-6119

Background: Pulse pressure (PP) is an independent predictor of cardiovascular disease microalbuminuria in non-diabetic people. Reduced circadian blood pressure (BP) variation has been identified as a risk factor for diabetic complications. In a sample of type 2 diabetic patients, we looked at the relationship between retinopathy, nephropathy, macrovascular disease, PP, and diurnal BP change.
Method: We performed a 24-hour ambulatory blood pressure (AMBP) and fundoscopy on 100 type 2 diabetes patients, and urine albumin excretion was measured using the urinary albumin / creatinine ratio. It was determined whether or not macrovascular disease existed.


Desai Jabbar V; Amite Porwal; R. J. Kapale; Bopal N. Pujari; Dilip P. Patil

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4149-4155

Albumin is the main protein that is usually located in the blood, but when the kidneys are functioning well, virtually no albumin is found in the urine. When the blood flows into balanced kidneys it flushes excess products and provides the items that the body requires, such as protein. Our study aimed to assess and standardize the spot (random) urinary albumin creatinine ratio (UACR) method for the proteinuria assessment. A urine albumin test (formerly known as microalbumin) detects and measures the amount of albumin in the urine for kidney disease checking. Based on spot urine albumin, 50 percent of patients had micro albuminuria and 40 % had normal urine albumin levels and remaining had macroalbuminuria. Mean urine albumin levels were 107.38 mg/dl.