Online ISSN: 2515-8260

Keywords : GCF


SALIVARY AND GINGIVAL CREVICULAR FLUID: PSYCHOLOGICAL STRESS BIOMARKERS IN PERIODONTAL DISEASE. PSYCHOLOGICAL STRESS BIOMARKERS IN PERIODONTAL DISEASE

1 Dr PoojaPalwankar , Dr DeepshikhaTyagi, Dr LipikaGopal, Dr PoojaPalwankar

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 4852-4858

Periodontal diseases are associated with local and systemic risk factors. Stress is one of the risk factors for periodontal diseases. This review is aimed to assess the relationship between the gingival crevicular fluid and salivary levels of psychological stress biomarkers and periodontal disease. The Electronic literature search was conducted through online search engines Pubmed, Scopus, WOS articles published from 2010 to April 2021. Cross-sectional and case-control studies that investigated the association between stress biomarkers and periodontal disease were included. Review paper, animal studies, Interventional studies were excluded from the search. Results from the observational studies suggest that elevated levels of psychological stress biomarkers were observed in salivary and gingival crevicular fluid levels of subjects with periodontal disease in contrast to the healthy controls. Within the limitations of the study Psychological stress biomarkers are correlated with the severity and complexity of periodontal disease

Assessment of collagenase activity and MMP levels in GCF and in peri- implant sulcular fluid in healthy, chronic periodontitis and peri- implantitis patients

Dr. Ashima Trivedi; Dr. Shwetha N; Dr. Ankita Priya; Dr. Doddy Lokanathan Balaji; Dr. Anjaneya Mahapatra; Dr. Kaumudhi Kalla

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5274-5278

Background: The present study was conducted to assess collagenase activity and MMP levels in GCF and in peri- implant sulcular fluid in healthy, chronic periodontitis and peri- implantitis patients.
Materials & Methods:40 patients of both genders were divided into 4 groups. Group I patients were healthy, group II had healthy dental implants, group III patients had periodontitis and group IV had peri-implantitis. Collagenase activity wasmeasured using a DNP-synthetic octapeptide.
Results: The mean gingival index was 0.6 in group I, 1.1 in group II, 2.2 in group III and 2.3 in group IV. Probing depth was 3.2 in group I, 2.5 in group II, 5.7 in group III and 5.1 in group IV. Collagenase activity per site was 1.7, 0.5, 15.2 and 14.7 in all groups respectively. Collagenase activity per ml was 9.2, 2.2, 16.4 and 21.6 in all groups respectively.
Conclusion: Peri-implantitis PISF contained higher collagenase-2 levels. GCF and PISF from severeCP and PI exhibited the highest activation of MMP-8 isoenzymes species.