Online ISSN: 2515-8260

Keywords : Autoimmune


“Study Of Autoimmune Thyroid Disorders In Chronic Spontaneous Urticaria.”

Meghana Pendam; Dr. Bhushan Madke

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 3592-3600

Background: Chronic spontaneous urticaria known to be autoimmune which is linked to thyroid autoimmunity, but observation of autoimmunity relation with CSU progression and prognosis is less.Therefore the study of thyroid gland autoimmunity and autoimmunity in chronic spontaneous urticaria indicates a relationship between chronic spontaneous urticaria and thyroid autoantibody.
Aim: To study the auto immune thyroid disorders in chronic spontaneous urticaria.
Objectives:The primary goals of this research are:
1. To research the clinical characteristics of chronic spontaneous hives.
2. T3, T4, TSH and ANTI-TPO ANTIBODIES study in patients with chronic spontaneous urticaria and controls
3.To study the correlation between the above parameters and chronic spontaneous urticaria
4.To study the correlation between severity of chronic spontaneous urticaria and autoimmune thyroid disorders.
Materials And Methods:Patients having chronic spontaneous urticaria,after considering the different inclusion and exclusion requirements, those who will come to the Department of Dermatology, Venereology and Leprosy, AVBRH, Sawangi, Wardha, will be enrolled. Clearance will be sought from the Institutional Ethical Committee (IEC). All participants will obtain written informed consent in their vernacular language for voluntary participation. A comprehensive history will be taken with regard to name, age, gender, family history, past history. Patients with chronic spontaneous urticaria will be subjected to a thorough clinical review. Patients will be scored based on urticaria severity scoring.
Expected Results: This research will take preventive steps to treat patients with chronic spontaneous urticaria and in patients with deranged parameters, an assay for T3, T4, TSH and ANTI-TPO can be done . Further, this can facilitate the early detection and arrest of progression of autoimmune thyroid disorders in chronic spontaneous urticaria.
Conclusion:. This research would help to screen patients with chronic spontaneous urticaria for autoimmune thyroid disorders. It can later be considered as a mandatory protocol to be evaluated in chronic spontaneous urticaria patients.

Hormone Profile In Hashimoto Thyroiditis And Its Clinicopathological Correlation

Volga Harikrishnan; Ranjitham T. P

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 3592-3600

Background: Hashimoto thyroiditis is a common autoimmune disorder. Clinically, they may present as thyroid swelling with hypothyroid, hyperthyroid or in euthyroid state. Objectives: To evaluate the hormonal status in Hashimoto thyroiditis and to correlate the hormonal status with clinical and pathological parameters. Materials and methods: We retrospectively studied 40 Hashimoto thyroiditis cases proven by FNAC, and each case was evaluated. Ethical approval was obtained before conducting the study. This was an ICMR approved study. Result:According to this study many of the Hashimoto thyroiditis patients reported at the terminal stage only after a year with diffuse swelling with hypothyroid status, it was commonly reported among female between age group of 31-35 years of age. Hypothyroid status was commonly reported after a year with diffuse swelling among female between age group of 31-35 years. Cases with hyperthyroid status were commonly reported within a month with diffuse swelling among female between age group 31-35years. Euthyroid status was commonly reported within a year with diffuse swelling among female between age group 31-35years and 41-45years. Conclusion: Irrespective of the presentation of the patient, especially in female in the age group of 31-35years with thyroid swelling, FNAC should be performed to diagnose Hashimoto thyroiditis. FNAC is an excellent tool for investigation as it can help in the early detection and preventing disease progression in Hashimoto thyroiditis