Online ISSN: 2515-8260

Keywords : Allergic rhinitis


A Study of Role of Diethylcarbamazine in Allergic Rhinitis with Eosinophilia

Santosh Kumar; Sushant Kumar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 866-873

Background and Objectives: Although not as glamorous as its surgical counterparts, the management of allergic rhinitis constitutes a large proportion of the day-to-day practice of the general otolaryngologists. In addition to its primary effect, inhalant allergy of the upper respiratory tract might affect the development and clinical course of other disease states such as sinusitis, otitis media, and asthma accounting upto half the patients encountered in an otolaryngological practice. Diethylcarbamazine an antifilarial drug used in the treatment of tropical pulmonary eosinophilia was used in this study to know its role in allergic rhinitis.
Method: A Descriptive study was conducted for one year at Department of DMCH Darbhanga. Selected Patients were administered Tab Diethylcarbamazine 5mg/kg body wt BD for 21 days and their effect on symptom control, blood eosinophilia and nasal   eosinophilia wasstudied. Results: About 100 patients were recruited. 78 patients had eosinophilia either in blood, nasal smear orboth which accounted to significant amount. After treatment with Diethylcarbamazine blood Eosinophilia decreased significantly in both blood and nasal tissue and blood eosinophilia only group. Nasal Eosinophilia decreased significantly in both blood and nasal tissue and nasal tissue only group. Symptoms of sneezing, rhinorrhea, nasal obstruction, nasal pruritis, eye watering and eye itching improved significantly in all 3 groups after treatment. Pharyngeal itching improved only in blood & nasal eosinophilia and blood eosinophilia group. No improvement in Anosmia in all 3 groups.
Conclusion: Eosinophilia was associated in significant number of population and Diethylcarbamazine is useful in reducing the symptom scores in patients of allergic rhinitis with eosinophilia. It also reduces the eosinophil scores in both blood and nasal tissue. Diethylcarbamazine can be used in the treatment of allergic rhinitis with eosinophilia as an adjunctive drug.

A Study of Role of Diethylcarbamazine in Allergic Rhinitis with Eosinophilia

Santosh Kumar, Sushant Kumar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 8503-8510

Background and Objectives: Although not as glamorous as its surgical counterparts, the management of allergic rhinitis constitutes a large proportion of the day-to-day practice of the general otolaryngologists. In addition to its primary effect, inhalant allergy of the upper respiratory tract might affect the development and clinical course of other disease states such as sinusitis, otitis media, and asthma accounting upto half the patients encountered in an otolaryngological practice. Diethylcarbamazine an antifilarial drug used in the treatment of tropical pulmonary eosinophilia was used in this study to know its role in allergic rhinitis.
Method: A Descriptive study was conducted for one year at Department of DMCH Darbhanga. Selected Patients were administered Tab Diethylcarbamazine 5mg/kg body wt BD for 21 days and their effect on symptom control, blood eosinophilia and nasal   eosinophilia wasstudied. Results: About 100 patients were recruited. 78 patients had eosinophilia either in blood, nasal smear orboth which accounted to significant amount. After treatment with Diethylcarbamazine blood Eosinophilia decreased significantly in both blood and nasal tissue and blood eosinophilia only group. Nasal Eosinophilia decreased significantly in both blood and nasal tissue and nasal tissue only group. Symptoms of sneezing, rhinorrhea, nasal obstruction, nasal pruritis, eye watering and eye itching improved significantly in all 3 groups after treatment. Pharyngeal itching improved only in blood & nasal eosinophilia and blood eosinophilia group. No improvement in Anosmia in all 3 groups.
Conclusion: Eosinophilia was associated in significant number of population and Diethylcarbamazine is useful in reducing the symptom scores in patients of allergic rhinitis with eosinophilia. It also reduces the eosinophil scores in both blood and nasal tissue. Diethylcarbamazine can be used in the treatment of allergic rhinitis with eosinophilia as an adjunctive drug.

A comparative study of intranasal steroids with intranasal antihistamines sprays v/s intranasal steroids sprays alone in management of allergic rhinitis

Somasundaram Subramaniam, Praveenkumar Jayaraj, Parameshwaran Arumugam

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 7089-7094

Background: Allergic rhinitis is a chronic upper airway disease of increasing prevalence and remains an important healthcare problem. Present study was aimed to compare intranasal steroids with intranasal antihistamines sprays v/s intranasal steroids sprays alone in management of allergic rhinitis. Material and Methods: Present study was comparative, prospective & non-randomized study, conducted patients from 18-45 years of age group, either gender, attending the ENT outpatient clinic, clinically diagnosed with allergic rhinitis. 60 patients by computer generated chits randomly allocated to group S (intranasal steroids) & group SA (intranasal steroids & intranasal antihistamines). Nasal Obstruction Symptom Evaluation (NOSE) score was calculated at baseline & after 6 weeks. Results: 60 patients were randomly divided in group S (n=30) & group SA (n=30). Both groups had comparable distribution of patients according to age & gender. Baseline NOSE score (Group S - 82.17 ± 10.52 & Group SA - 83.75 ± 11.94) were comparable & difference was not significant statistically (p - 0.078). At 6 weeks a significant fall in Absolute eosinophil count was noted in groups S (82.17 ± 10.52 vs 49.28 ± 7.56) as well as group SA (83.75 ± 11.94 vs 22.2 ± 6.97) & difference was statistically significant (p<0.001). At 6 weeks, less NOSE score was noted in group SA (22.2 ± 6.97) as compared to group S (49.28 ± 7.56) & difference was statistically significant (p - 0.021). Conclusion: Combination of intranasal steroids with intranasal antihistamines sprays has significant reduction of symptoms in allergic rhinitis patients when compared to intranasal steroids spray alone.

Pattern of Aeroallergen Sensitization in Children with Respiratory Allergy in North Indian Population

Radhey Shyam Sharma, Pratibha Shekhawat, Pooja Yadav, Gautam Lunia

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5755-5760

Background: Allergic diseases affects lives of more than one billion people worldwide(1).
Aeroallergen sensitization can be evaluated using either skin testing or measuring
specific IgE to these aeroallergens. Skin prick testing (SPT) is an easy, cost-effective and
convenient approachto identify sensitization to allergens.
Objective: To determine the pattern of sensitization to various aeroallergens and
prevalence of atopy in children with respiratory allergy.
Method: We performed a hospital based prospective observational study, conducted at
Paediatric OPD, SantokbaDurlabhji Memorial Hospital, Jaipur, India. Total 140
children of age 6years to 18 years diagnosed with Respiratory allergy (Allergic rhinitis
& Asthma) were enrolled. Skin prick test using 18 aeroallergens(indoor & outdoor)
were performed as per standard protocol.
Result: Among the total cases around 77% (n=108) were having positive skin test for
one or more allergens, most common allergens were HDM (35%), cockroach
(32.2%),Mosquito (32.1%), Grain dust (22.1%) and Heloptelia (20%).
Conclusion: SPT is the most convenient, cost-effective, sensitive and standardized
method for detecting allergen sensitivity and should be used in all children with allergic
disorders to demonstrate the atopy. More than 50% of children in our study had
sensitization to one or more aeroallergens suggesting atopy; sensitization was most
commonly seen to HDM antigen.

Allergic Rhinitis in Relation to Gut Microbiota Composition among School-Aged Patients

Samir Sourour, Mahmoud Diab, Rania M. Amer , Tarek Abdelmouty, Gehan A. Elshenawy, Saeid Abdelmonaem

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 457-465

Background: Allergic rhinitis (AR) is one of the most globally commondiseases and
usually persists throughout life. First-line drugs can be successfully used to control
AR. However, once these medications are terminated, the majority of AR patients
will reappear the symptoms of AR within a brief period. Thus, these medications do
not appear to exert a long-term effect on the baseline Total Nasal Symptom
Score.To study the relationship between the gut microbiota types and allergic
rhinitis. Patients and Methods: This case control study was carried out on 52
school-aged patients presented at Oto-rhino-laryngology, Head and Neck (ORLHNS)
Department and Microbiology and Immunology department at Zagazig
University. The patients were classified into 2 groups: Allergic rhinitis group: 26
individuals with allergic rhinitis Control group: 26 individuals without allergic
rhinitis. All patients in this study were subjected to the personal history taking,
physical examination and laboratory investigations including: eosinophilic count,
skin prick tests (SPT) for common perennial and seasonal allergens, measurement
of (total Ig E) and identifing bacteria (lactobacillus and bacteroides) by SYBR
Green real time PCR. Results: Age was distributed as 11.19±3.26 and 11.65±3.24
respectively between case and control with no significant difference between
groups. Mean disease duration was 6.15±2.01, the majority were Intermittent and
mild regard classification also the majority were trigger by inhalation. Skin prick
test among cases group showed majority were house dust and date palm pollens.
Absolute eosinophils counting was significantly higher among cases compared to
control one. Cases were significantly higher regard IgE distribution. Lactic acid
bacteria RNA was significantly higher among control group compared to cases
group while Bacteroid bacteria RNA was significantly higher among cases group
compared to control group. Conclusion: Lactic acid bacteria in gut microbiota of
school-aged individuals may influence sensitization to different allergens.

Assessment Of Risk Factors For The Development Of Allergic Diseases In Children

Nurmamatova Kurbonoy Choriyevna; Abdashimov Zafar Bahtiyarovich; Karimova Mukhabat Umarovna; Stojarova Nelli Kamilovna; Tangirov Abdixoliq Lolayevich

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 319-329

Allergy is a pathology of countries with a high index of socio-economic development and most of all residents of large cities. By 2025, according to the WHO, 50% of the world's population will suffer from allergies [14]. This article examines the main risk factors for the development of allergic diseases in children under the age of 18 in Tashkent. The most significant factors were: the presence of an inherited predisposition on the line of one (RCh 1.9) or both parents (OR 5.6), closely related marriages between parents (RCh 2.8), the age of parents over 40 at the time of conception of the child (RCh 1.4) and some others.

Influence of mouth breathing on oral health in children: A population-based crosssectional study in Nagpur city

Dr. Arunkumar Sajjanar; Dr. Nilesh Rojekar; Dr. Pankaj Chavan; Dr. Milind Wasnik; Dr. Niharika Gahlod; Dr. Harshita Shukla

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 7652-7659

Background/purpose
Previous studies have suggested that mouth breathing has harmful effects on oral health in
children, but the evidence has been insufficient. To investigate the association of mouth
breathing with oral health in school children aged 8–11 years from Nagpur city , India
Materials and methods
Cross-sectional data were obtained from March to April 2019. A questionnaire was used to
investigate children's mouth breathing habits and personal/family histories related to allergic
disease. Oral health status was determined through a clinical oral examination. Data were
analyzed with multivariable logistic regression.
Results
In total, 1007 children were included. We observed no association between mouth breathing
and dental caries in children. However mouth breathing was associated with child's tonsillitis
and was identified as a possible risk factor for class II dental malocclusion.