Online ISSN: 2515-8260

Keywords : Neonatal sepsis


RISK FACTORS ASSOCIATED WITH EARLY ONSET OF NEONATAL BACTERIAL SEPSIS IN BABIES BORN IN A RURAL TEACHING HOSPITAL- A PROSPECTIVE OBSERVATIONAL STUDY

Dr. NISHANTH. M, Dr.SHAIK K JOHN MOHAMMAD ALISHA ,Dr. MUJIBUR REHAMAN SHAIK .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5292-5300

Introduction: Early onset neonatal sepsis (EONS) remains a major cause for neonatal mortality and morbidity.To reduce neonatal mortality due to neonatal sepsis, preventive strategies are better than therapeutic measures.
AIM:To identify maternal and foetal risk factors associated with early onset neonatal bacterial sepsis (EONS), in babies born in a rural teaching hospital.
Methodology –During the study period, using simple random sampling method, total 204 neonates were selected. Of them, only 172 mothers of neonates (134 controls, 38 EONS cases) gave written informed consent.
Results- The birth weight was significantly low in babies who developed EONS (mean weight 2.39± 0.8) compared to that of the control group(mean weight 2.83±0.6).The Mean APGAR score at 5 minutes was significantly low in babies who developed EONS (7.15± 1.03) compared to that of the control group (9.3±0.9).Late preterm (GA 32 to 36 weeks) was a risk factor for EONS. Prematurity was significantly associated with EONS. Pregnancy domicile area of the mother was not associated with development of sepsis.
Conclusion-Ambuuse, Laryngoscope use, Oxygen use, ET intubation in the delivery room were not associated with EONS risk. Baby not undergoing or not needing gastric lavage in the delivery room was a protective factor against EONS.Keywords: Neonatal sepsis, Low birth weight, preterm babies.
 

Fetomaternal Outcome in Women Undergoing Caesarean Section in First Stage Vs Second Stage of Labour

Kesavachandra Gunakala, P.M.Rekha Rao, Mude Vennela, P.Harika

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 6052-6060

Background:Second stage caesarean is technically more difficult due to deep
engagement of fetal head, and this is associated with increased risk of maternal
morbidity such as surgical injuries and intra operative excessive haemorrhage as well as
fetal morbidity such as asphyxia and fetal injury. A Prospective study was done to
compare the maternal and neonatal complications of caesarean sections performed in
second stage compared to first stage of labour. Objective: To determine the maternal
and perinatal outcome associated with caesarean sections performed in second stage
versus first stage of labour.
Materials and Methods: It is an observational cross-sectional study where 7033 women
were enrolled in the study, out of them 1272underwent C- section in first stage of labour
where as rest152 underwent caesarean section in second stage of labour for various
indications.
Results: It was found that the women who underwent caesarean section in second stage
of labour had a higher risk of maternal morbidity than those who underwent caesarean
in first stage of labour The rate of intraoperative bleeding is>1000ml,uterineatony,
longer duration of surgery,adhesions, fetalhypoxia, neonatal admissions toNICU,
neonatal sepsis and early neonatal death were more common in second stage of labour
as compared to first stage.
Conclusion: In conclusion, Present study suggests that women undergoing c-section in
second stage of labour have increased chance of Uterineatony, rate of excessive
bleeding, postoperative fever, wound infection, fetal hypoxia compared to first stage of
labour and therefore require special care and should be handled and operated by
experienced obstetricians’ The rate of complications can be avoided by proper antenatal
care, proper usage of partograph, pelvic assessment in early labour and timely
intervention.

Aetiological profile, risk factors, antibiotic sensitivity pattern and outcome of neonatal sepsis in tertiary care hospitals- a prospective observational study

DR MAMTA KUMARI; DR RATAN KUMAR DASH; DR BRAJA KISHORE BEHERA; Dr DILLIP KUMAR DASH; Dr MAMATA DEVI MOHANTY; A S A M SRIKANT

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 1073-1087

Introduction:Neonatal sepsis is an important cause of morbidity and mortality in developing countries.According to the World Health Organization(WHO),around5 million newbornsdie yearly, 98% of deaths occurring in developing countries
Objectives: To identify prevalence of neonatal sepsis,aetiological profile,antibiotic sensitivity pattern and outcome in a tertiary care centre and to formulate a consensus recommendation for empirical antibiotic usage for neonatal sepsis in our hospital.
Method:A hospital based prospective observational study was done from March 2019 to August 2020 on babies diagnosed or suspected as cases of neonatal sepsis in our hospital.
Results:Atotal of 200 neonates were included in our study with clinical suspicion of sepsis during the study period. 127 (63.5%) neonates were identified as EOS (0-3 days) and 73 (36.5%) aslate onset sepsis (4-28 days).Prematurity was thecommonest predisposing factor(68.5%).Feeding intolerance was the commonest presentation (74%).Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of C-reactive protein (CRP) + absolute neutrophil count (ANC) were 93.8% ,90.8%, 34.9%, 99.6% and 90.9% respectively.(p <0.001).Klebsiella pneumonia + Klebsiellaoxytoca(16+1) was the most common isolate (35.4%),There were 6 (12.5%) isolates of Staphylococcus aureus out of which 2 were methicilin resistant aureus(MRSA).
Conclusions:Of the 200 neonates with suspected neonal sepsis,63.5% had EOS. Prematurity was the commonest predisposing factor(68.5%) and feeding intolerance was the commonest presentation (74%).Klebsiella (35.4%) was the most common isolate.