Online ISSN: 2515-8260

Keywords : Brown's model

Prediction of tumor parameters based on regression models for rats for combined treatment with hyperthermia and chemotherapy

Evgeny Kostyuchenko; Elena Kataeva; Denis Pakhmurin; Polina Shelupanova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 1317-1332

The paper considers the possibility of predicting tumor parameters (weight, volume) depending on the method of treatment and doses of drugs used. A comparison is made of the applicability of several regression models, taking into account the limited amount of data. Brown's adaptive model, paired regression, multiple regression are compared. Previously, all constructed regression models were tested for adequacy by assessing the significance of the coefficient of determination according to Fisher's criterion, and only the models that were recognized as adequate were used for further predictions. The advantage of Brown's model on the considered limited data set is shown experimentally and recommendations are given on the choice of the method parameters.