Online ISSN: 2515-8260

Keywords : Schizophrenia

Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder

Oleg V. Ermilov; Andrey Yu. Tretyakov; Lyubov V. Romasenko; Nina I. Zhernakova; Elizaveta S. Rudycheva; Inna V. Tikhonova; Irina A. Misan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 122-127

Objective: To describe the features and mechanisms of development of metabolic
syndrome (MS), type 2 diabetes melitus (DM2) and intermediate states of glycemia in
psychosis the occurrence of these disorders, the values of total cholesterol (TC),
fractions of high density lipoproteins (HDL), very low density lipoproteins (VLDL),
triglycerides (TG), values of atherogenic coefficient (AC), insulinemia, С-peptidemia,
insulin resistance (IR) the level of glycated hemoglobin (HbA1c) in a sample of patients
with schizophrenia and in mentally healthy individuals.
Materials and methods: The frequency of carbohydrate metabolism disorders (CMD) was
studied. Fasting glycemia was determined, and in the presence of its violation, a glucose
tolerance test was performed. MS components were studied in patients with DM2,
plasma concentrations of TC, HDL, VLDL, TG, C-peptide (CP), insulin and HbA1c were
determined in patients with DM2, AC values and IR indices were calculated using
HOMA-IR and CARO criteria.
Results: CMD in schizophrenia are more common than among mentally healthy subjects,
amounting to 13.1% (p=0.02), and the main condition here is a significant number of
individuals with impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT)
among women (CMD p=0.01; IGT p<0.001; IFG p=0.03). A feature of psychiatric
sampling is a decrease in HDL by 16.4% (p=0.03) and an increase in AC by 52%
(p=0.02). Mentally ill men with MS are characterized by a significantly large value of AC
(p=0.019), insulinemia (p=0.02), CP level (p=0.02), HOMA-IR (p=0.01) and CARO
(p=0.04) values than in mentally ill patients with DM2 without MS. In comparison with
the control, regardless of gender, the schizophrenic patients with DM2 have significantly
lower values of insulin (p=0.03), C-peptidemia (p=0.04) and IR, according to the criteria of
HOMA-IR (p=0.01) and CARO (p=0.03).

Determinant Factors Related to Relapse of Schizoprenic Patients at the Islamic Mental Hospital

MahyarSuara .; Sandeep Poddar; Roy Rillera Marzo

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 129-139

Background: During the last century, there has been a high increase in health problems in the world, including Indonesia, one of it is mental health. The actual prevalence of mental health disorders worldwide remains poorly understood. Mental health is very much underreported, and under-diagnosed.
The purpose of this study was to identify factors associated with schizophrenia relapse of patients at the Islamic Mental Hospital in Jakarta, Indonesia.
Settings and Design
The research method with a quantitative approach was performed with a total sample comprisedof 150 respondents using primary data.
Material and Methods
The data collection method used was library research, field research (observation), and questionnaire research design through a cross-sectional approach.
Statistical Analysis
Univariate analysis process (frequency distribution) and Bivariate analysis with the Chi-square test and multi-variate with path analysis was used in this study
Based on the results of the validity of the instrument, the variable of compliance for taking medication (X1), Stress variable (X2), Drug Abuse variable (X3), the Psychology variable (X4), the variable of Emotional Expression (X5), Relapse among schizophrenic patients (Y) was considered. The results revealed that the correlation of the adherence to the antipsychotic drugs consumption (X1), stress level (X2), and psychological response (X4) to the relapse in schizophrenia patients (Z) is acceptable, whereas the strongest or dominant correlation is the stress factor (X2).
The results of this study can provide a plan for schizophrenic patients in the country. Since schizophrenic patients need medication and treatment for a long time, the researchers recommend for the government to provide medical assistance.