Online ISSN: 2515-8260

Keywords : mefenamic acid


SYNTHESIS OF REMARKABLE SUBSTITUTED ARYL 1,3,4-OXADIAZOLE DERIVATIVES AND THEIR POTENT ANTIINFLAMMATORY AND ANALGESIC ACTIVITIES

Vishal kumar; Satish Kumar Sharma; Rizwan Ahmad

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4406-4415

The key objective of the current research is to synthesize and analgesic action 5- (2-(2,3-dimethylphenylamino)phenyl)-2-(aryl)- 1,3,4-oxadiazole and to test this activity (VT1- VT8). During this investigation, the condensed methanone {2-[(2,3- dimethylphenyl)amino]phenyl}(hydrazinyloxide), and various aryl-acids in presence of phosphorous oxychloride were synthesized in the present investigations by a sequence of 5-(2- (2,3-dimethylphenylamino)phenyl]-2,3,4-oxadiazols (VT1-VT8). Both synthesized compounds have been tested with 50 mg/kg and 10 mg/kg po respectively for their in vivo antiinflammatory and analgesic activities. Carrageen's mediated acute rat paw oedema model and Eddy's hot plate system were used to analyze the anti-inflammatory and analgesic function of the synthesized compounds. Any substances have been effective at their anti-inflammatory and analgesic activities, according to biological results. Elemental research (C, H, N) and spectral analysis also verified the composition of both substances (IR, 1H NMR and mass spectrometry).

The Synergistic effect of non-steroidal anti inflammatory drugs on antibacterial activity of ceftriaxone against streptococcus pyogenes Isolated from patients with pharyngitis

Suaad Traiji Zamil; Raad Abdulameer Alasady; Rana Talib AlNafakh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4483-4488

Background: Streptococcus pyogenes cause major infectious problems including pharyngitis, scarlet fever, and rheumatic fever Emergence of resistant strains make such infections and relevant complications (e.g., rheumatic valvular disease and glomerulonephritis) a serious clinical challenge especially in children. Aims and objectives: In a maneuver of overcoming the resistance developed by S. pyogenes and improving the ability of antibiotics to fight such bacteria, a nonsteroidal anti-inflammatory drug NSAID is repurposed as antimicrobial against S. pyogenes, in objective to be united with the usual antibiotic mentioned by WHO principle of care. The combination was evaluated for its MIC and combination index versus S. pyogenes. Materials and Methods: From patients, suffering pharyngitis a multidrug-resistant strain of S. pyogenes was insulated. The maximum dangerous isolate was cultivated for MIC determination ceftriaxonemefenamic acid combination in comparison with each alone to establish the combination index. Results and conclusions: There were a pointed synergism concerning ceftriaxonemefenamic acid (index ˂ 1) at P= 0.012 and Z score= 2.3 additional validation of MIC folds of dilutions are to be evaluated to achieve rational evidence. Recommendations: We suggested to additional validate the antistreptococcal effect of the combined ceftriaxonemefenamic acid on more dilutions of MIC assay and to identify the benefit of this combination in patients developed pharyngitis induced by S. pyogenes.