Online ISSN: 2515-8260

Keywords : D-Dimer

Laboratory Markers Versus Ct Severity Score In Predicting Mortality In Covid 19

B.S.Gopala Krishna; P.Pranay Krishna; V.Ravi Sankar; Kondle Raghu; A.Siva Kumar; M. Srikanth; V. Satyanarayana; P. Siri Priya

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 1824-1831

Aim: Predicting the mortality of COVID-19 with a spectrum of complications is a difficult task for prognostication and management. When individual level data of COVID-19 patients were not yet available, there is a need for risk predictors to support the treatment decisions. The study aims to identify the high accurate marker to measure the prognosis and outcome of COVID19.
COVID-19 course is divided into four stages, according to chest computed tomography (C.T.) progress. The demographics, disease exposure history, clinical condition, laboratory tests, computed tomographic chest scan, and outcome data were collected and measured their correlation to assess the risk predictor.
The 10.4% mortality (n=52) was observed in total population. D-dimer (μg/dL) levels observed as 0.75 ± 0.65 in expired patients. NLR ratio observed as 17.1 in expired patients. Ferritin levels were observed as 49.8 ± 32.5 in expired patients. A D-dimer positive predictive value of 72.5% and a negative predictive value of 88% for a predictor of mortality. Ferritin positive predictive value of 35.5% and a negative predictive value of 76.5% for the predictor of mortality. Hence, the AUC of serum ferritin 0.598 represents the poor ability to discriminate the prediction for the cause of death than D-dimer levels. D‐dimer > 2 μg/dL on admission was associated with in‐hospital death. These main findings indicate that D‐dimer on admission >2.0 μg/dl was the independent predictor of hospital death in patients with Covid‐19. A D-dimer has the highest positive predictive value than serum ferritin levels.
Conclusion: The AUC for D- dimer at admission was 0.880, with an optimal cutoff of 2.2 μg/dL in predicting the cause of mortality. D‐dimer on admission > 2.0 μg/mL (fourfold increase) is the best predict in‐hospital mortality and a helpful marker to improve the management of Covid‐19.

Assessment of the D-Dimer Levels and their Correlation with Lymph Node Involvement in Carcinoma Breast

Dr. Gaurav Kataria; Dr Preeti Juneja

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 8840-8844

Background:Mammography is a widely used screening approach in the detecting of breast
cancer and proved to help reduce the mortality effectively. D-dimer (or D dimer) is a fibrin
degradation product (or FDP), a small protein fragment present in the blood after a blood
clot is degraded by fibrinolysis. Hence; the present study was undertaken for assessing the
d-dimer levels in carcinoma breast.Materials & methods:A total of 25 breast carcinoma
patients were enrolled.Data was collected using self-structured Performa which consisted
of detailed history, thorough examination, investigations and results. Blood venous
samples (3 ml) were collected from all patients before any surgical intervention, and
clinical staging was done. All the results were recorded and analysed using SPSS software.
Results:Mean D Dimer levels were found to be 2.458 μg/mL.Mean D-Dimer levels among
patients with and without lymph node involvement was 2.896 μg/mL and 1.354 μg/mL
respectively. Significant results were obtained while comparing the mean D-Dimer levels
among patients with and without lymph node involvement.Conclusion:D-dimer was found
to be an independent predictive factor for lymph node metastasis. However; further studies
are recommended.