European Journal of Molecular & Clinical Medicine

Background: Ovarian cancer is the most frequent cause of death from gynaecological cancers and the fourth most frequent cause of death from cancer in women in Europe, United States and India. The present study was conducted to assess distribution of neoplastic and non- neoplastic ovarian lesions.
Materials & Methods: 74 patients age ranged 18- 48 years was recorded. The histological characterization of ovarian tumour was done according to the International Classification of Diseases, (WHO Classification, 1995).
Results: Age ranged 18- 28 years had 24, 28-38 years had 40 and 38-48 years had 10. Common non- neoplastic lesions were simple serous cyst in 13, luteal cyst in 20, salpingo-oophoritis in 3, hemorrhagic cyst in 8 and endometriosis in 6 patients. Common neoplastic lesions were germ cell tumor seen in 12, epithelial tumors in 6, sex cord stromal tumour in 4 and metastatic tumors in 2 patients. The difference was significant (P< 0.05).
Conclusion: Most common non- neoplastic lesions was simple serous cyst, luteal cyst and hemorrhagic cyst and neoplastic lesions was germ cell tumor.

The organophosphorus pesticide, monocrotophos induced toxicity in fish’s adobe has been studied to access the biochemical and hormonal disruption caused in the liver and ovary of the fish. Monocrotophos pose serious risk to biochemical parameters, enzyme activities and level of hormones in the fishes. A direct relationship between concentrations of monocrotophos, elevated cholesterol levels and depressed estradiol concentrations have been traced in the study. The elevated levels of cholesterol in the ovary apparently reflect the reduced rate of its utilization for steroid synthesis by the ovary as significant effect of pesticide. The decreased estradiol level causes decreased production of vitellogenin as well as hampers the development of oocytes in ovary of Cyprinus carpio communis which was also evident in the experiments