Online ISSN: 2515-8260

Keywords : treatment


DIAGNOSIS AND TREATMENT ASPECTS OF SECONDARY NEUROENDOCRINE CHANGES IN ACUTE TWIN BRAIN INJURIES

Kuldasheva Yayraxon Mirzakarimovna; Xaydarova Feruza Alimovna - d.m.n., prof.; Kuldashev Kahramonjon Abdukhalilovich; Khakimova Zilola Kahramonjonovna; Inomova Gulmira Kakhramonjonovna

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 572-581

Nowadays, neuroendocrine symptoms following twin brain injuries (twin brain injuries) are more common and negatively affect the outcome of Brain Double Injuries by reducing the overall quality of life. However, research from the scientific literature suggests that neuroendocrine dysfunctions, particularly hypopituitarism, play an important role in the etiology of complications. It has been found that postoperative hypopituitarism has been a clinically common phenomenon in the last twenty years and is likely to contribute significantly to these disorders, given the parallelism of adenohypophysis among those following neuroendocrine changes associated with hypopituitarism other than cerebral palsy. In this our scientific study, we sought to explore hypothesized pathophysiological mechanisms based on neuroendocrine anomalies after a Brain Double Injury through an overview, improved on the basis of an analysis of early diagnosis and treatment aspects

MULTISPIRAL COMPUTED TOMOGRAPHY AS AN INSTRUMENTAL METHOD FOR SUBSTANTIATING THE PLACEMENT OF THE ACETABULAR COMPONENT OF THE HIP JOINT ENDOPROSTHESIS IN DYSPLASTIC COXARTHROSIS

Azizov Abror Mirxakimovich; Stupina Nadejda Vladimirovna; Xakimov Аkrom Dilshodbekovich; Valiev Odil Erkinovich; Nimatov Firuz Samadovich; Maxmudov Аrtur Аxmadovich; Tilyakov Xasan Аzizovich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 2311-2317

to assess MSCT and clinical and radiological features of dysplastic coxarthrosis.

COVID-19 care options: Facts and Challenges

Dr.Nandhana Prashanth V; Dr.Ravikanth P

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5694-5700

In December 2019, an outbreak due to extreme acute Coronavirus 2 (SARS-Cow-2) respiratory syndrome was first identified in Wuhan, China. The 2019 global coronavirus disease (COVID-19) pandemic in 2020 culminated in an extraordinarily strong risk for spreading. No medications in large-scale trials have been validated with substantial effectiveness of clinical care for COVID-19 patients considering the declining pattern of COVID-19. Remdesivir is deemed the most promising antiviral agent; it acts by inhibiting RNA-dependent polymerase RNA function (RdRp). No medications in large-scale trials have been validated with substantial effectiveness of clinical care for COVID-19 patients considering the declining pattern of COVID-19. Remdesivir is deemed the most promising antiviral agent; it acts by inhibiting RNA-dependent polymerase RNA function (RdRp). No medications in large-scale trials have been validated with substantial effectiveness of clinical care for COVID-19 patients considering the declining pattern of COVID-19. Remdesivir is deemed the most promising antiviral agent; it acts by inhibiting RNA-dependent polymerase RNA function (RdRp).

CORRECTING POSTOPERATIVE ANAL INCONTINENCE IN CHILDREN

Bilim Terebaev; Shakhnoza Abzalova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 997-1003

61 patients aged 3 to 14 years were treated with a diagnosis of postoperative anal incontinence (AI). Gel plastic surgery of the anal canal in patients with postoperative AI is the method of choice and is an alternative to reconstructive plastic interventions. During the operation, the creation of an internal nephosphincter from a bypass muscle coupling is advisable to perform with preliminary stomatization of the colon. The final result is largely determined by the quality and timing of rehabilitation measures in the near and remote postoperative period.

Treatment Of Patients With Asymptomatic And Mild Case Of Covid-19 Infection And Its Prevention In Outpatient Basis By Using Infrared Resonance Therapy

Alisher Alimov; Rustam Rakhimov; Ulugbek Alimov; Alisher Azizov

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 5356-5358

About 7 months, the whole world has been plunged into the coronavirus pandemic. And each time, caronavirus infection surprises medical workers with its new abilities to affect various organs and systems of the body, which makes it more dangerous for humanity [5, 6].
Unfortunately, for now, there is no specific treatment and prevention for Covid-19 have not find out [7, 8]. Non-specific prophylaxis of coronavirus infection is aimed at to close borders and to stop spreading of Covid-19 into the territory of the Republic, regulated by the Resolution of the Cabinet of Ministers of the Republic of Uzbekistan dated March 23, 2020 No. 176 "On additional measures to prevent the spread of coronavirus infection", By the Decree of the President of the Republic of Uzbekistan No. PP-4649 dated March 26, 2020 "On additional measures to prevent the wide spread of coronavirus infection in the Republic of Uzbekistan", by the Decree of the President of the Republic of Uzbekistan No. PP-4652 dated March 26, 2020 "On additional measures to support medical workers and employees of the sanitary and epidemiological service involved in countering the spread of coronavirus infection. " Despite certain advances in drug therapy for patients with Covid-19, the number of temporary disability of patients for several months is increasing, as well as complications associated with thrombosis of the vessels of the heart and brain, leading to disability for all life.
In this regard, the improvement of methods of prevention and treatment in the rehabilitation period of patients with Covid-19 remains an urgent problem of medicine.
During many years in medical practice we use infrared resonance therapy according to the method of R.Kh. Rakhimov to treat various diseases, to disinfect viral infections, pathogenic microflora and to improve vascular microcirculation, as well as to increase immunity [1, 2, 3 and 4].

A REVIEW ON USE OF TOCILIZUMAB FOR THE TREATMENT OF COVID-19

Dr.Elayakumar S.T; Dr. Anbumalar M

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5752-5757

Although a viral infection begins in COVID-19, some patients have overly exuberant inflammation, leading to acute pulmonary injury and a condition of adult respiratory distress (ARDS). As IL-6 is a key role in the inflammatory response, in this single centre observatory study in all Covid-19 patients with a proven SARS-CoV-2 fast-pacing infection in order to escape ALI and ARDS we have assessed the effectiveness and protection of tocilizumab (TCZ). In this single centre The rate of mortality in 104 patients treated for COVID-19 was lower (5 · 8%). The percentage of patients treated with COVID-19 was 11% lower than in untreated patients who had our level of treatment alone and a marginally lower rate of mortality (6 percent ). The acute phase reagents, Ferritin, and liver protein releases were quickly diminished by TCZ. Slowly, D-Dimer declined. Relevant safety issues were not found. An early prescribing of IL6-R antagonists can be safe and successful for avoidance, ICU admission and more complications in COVID-19 patients with imminent hyperinflammatory reaction1.

AN SYSTAMATIC REVIEW ON USE OF CHLOROQUINE FOR THE TREATMENT OF COVID-19

Dr.Arun Kumar; Dr.Monisha S

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5365-5374

The therapy of COVID-19 has attracted great interest in Chloroquine. The latest focus on these chloroquine applications has contributed to a survey on the effect and possibility of hormonobiphase dose reaction on extremely biologically different models. The examination showed that chloroquin usually induced hormetal effects that impacted many types of cells, including tumour cell lines (e.g. human breasts, colons, colones) and non-tumor cell lines, improved viral reproduction, motility of semen, varied behavioural endpoints, and decreased the risk of convulsions. These diverse and nuanced findings indicate that hormetic dose reactions with different biological models and endpoints are common in chloroquine treatments. These findings impact the nature of the study, including dosage number and distance, and suggest a variety of clinical challenges and opportunities focused on the expected outcome.

PAN FACIAL FRACTURE – A CASE REPORT

Dr. Vijay Ebenezer; Dr. Rakesh mohan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 1505-1508

Pan facial fractures are complex to treat and hence have to be systematically managed . Several authors have quoted several principles regarding the repair of pan facial fractures in a stepwise fashion . The most important goal is to restore the occlusal relationship at the beginning of the treatment , so that all the other structures get aligned . The folllowing is a case of a traumatic pan facial fracture and its surgical management

White Lesions and Laser Therapy a Clinical Study

Dr.Ruchi Bhuyan; Dr.Sanat Kumar Bhuyan; Sidhant Bhuyan; Akankshya Sahu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1136-1143

Objective: To test the diagnosis of oral leukoplakia with diode laser.
Materials & methods: Throughout this investigation we found five cases of oral leukoplakia that were validated through biopsy then diagnosed using laser diode.
Results: Diode laser offers pain free and fast tissue repair resulting from the procedure. The time of recovery lasted from 7 days to 30 days well after laser cure and no resection from 2 years well after research.
Conclusions: The diode laser seems to be an effective means of handling contaminated wounds and helps avoid malignancy by treating oral leukoplakia.

An Exploratory Study on Ketogenic Diet and Nutrition

Dr.Magesh V; Dr.Mutharasu C

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5716-5722

In the US, dietary recommendations in >50 y centered on reducing saturated and total fat intakes. During this time, however, obesity and diabetes rates have dramatically increased, with potentially devastating consequences for public and economic health. Ketogenic diets have recently gained extensive media interest and nutrition studies. During this time, however, obesity and diabetes rates have dramatically increased, with potentially devastating consequences for public and economic health. Ketogenic diets have recently gained extensive media interest and nutrition studies. In addition to decreases in blood glucose and insulin, which can be accomplished by reducing carbohydrates, persistent ketosis could convey specific metabolic advantages that are important for cancer, neurodegenerative disorders and other insulin resistance conditions. Based on existing data, a well-formulated ketogenic diet does not seem to have significant public safety issues and should be seen as a key solution to obesity and diabetes. Medical studies of good consistency.

C-reactive protein and periodontal disease – A Review

Mohana Kondapally; Ramesh KSV; NVS Sruthima; Gautami S Penmetsa; P. Mohan kumar; G. Meghana

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 5, Pages 1664-1670

C- reactive protein (CRP) is an acute phase protein observed in increased quantities in plasma during the infections and presence of any inflammation, which could be a further possible risk factor in systemic inflammatory diseases such as arthritis, diabetes mellitus, and obesity. CRP molecules help as a biological marker for the determination of the inflammatory process when obtained from the gingival crevicular fluid and there is association between periodontitis and CRP levels. These levels are found to be reduced after the non-surgical and surgical periodontal treatment. Therefore, the levels of CRP would play a major role in determination of the inflammatory process.

STUDY OF EFFICIENCY OF ROSAСEA THERAPY DEPENDING ON TNF-α GENE RS1800629 POLYMORPHISM

Babajanov O.A; Arifov S.S .; Abzalova Sh.R .; Urinbaeva D.A .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2365-2369

The results of the study of the distribution frequency of the genotypes of the
polymorphism of the rs1800629 TNF-α gene involved in the formation and clinical course
of rosacea are revealed, which allows us to predict the development, course of the disease
and to develop the optimal scheme for its prevention and treatment. We studied the
polymorphism of the rs1800629 TNF-α gene in rosacea patients and determined the
effectiveness of therapy depending on the severity and frequency distribution of genotypes

TRANSOSSEOUS OSTEOSYNTHESIS IN THE TREATMENT OF FRACTURES OF THE PROXIMAL TIBIA

Boymurodov G. A.; Dursunov A.M .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1110-1112

The treatment of fractures of the proximal tibia is at the center of surgery traumatology. A high percentage of complications and unsatisfactory functional results require the development of methods for the osteosynthesis of fractures of the proximal tibia. Various complications associated with bone regeneration, such as pseudoarthrosis and delayed fusion, occur mainly with a conservative flight. When using external fixators in the proximal part of fractures of the tibia, the probability of their association is high. The article uses the results of treatment of 132 patients with various methods. The treatment results were healed by other methods of osteosynthesis.

MINISCREW ASSISTED RAPID PALATAL EXPANDER- AN ALTERNATIVE TO CONVENTIONAL EXPANDERS

Dr. Kalai Selvi A; Dr. Saravanan; Dr. M.S. Kannan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 1653-1657

Expansion has been one of the oldest means and also conservative method of gaining space and correcting the intermaxillary and dental arch relationships primarily in transverse direction. As clinicians we all rely on some form of rapid or slow palatal expansion appliances to produce maxillary change. Various appliances and treatment techniques have been developed and used to correct the transverse discrepancies. The most common is rapid maxillary expansion (RME) performed with a tooth-anchored expander. However the predictability of orthopedic expansion is greatly reduced after 15 years of age. Due to this reason, it has been proposed that the MARPE is an effective alternative to maximize the skeletal effects in adults and also to avoid invasive surgical procedures like SARPE .

Features Of Thrombophilia In Covid-19

Dadajanov Utkur Dadajanovich; Mamatkulova Feruza Xaydarovna; Ruziboeva Oyjamol Narzullaevna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 5199-5205

from this article we see that why COVID-19 causes thrombosis, A thrombus is a mixture of platelets, erythrocytes and fibrin protein, which begin to accumulate on the wall of the damaged vessel. gradually it thickens and hardens, but in general it resembles a viscous substance, similar to jelly,it can be unambiguously stated that with this virus, from the very beginning, there is an activation of hemostasis, intravascular blood coagulation and thrombus formation in small-caliber vessels of vital organs. In this case, not only the lungs are damaged, but the blockade of microcirculation and its irreversible nature determine the outcome of the disease.

DYSLIPIDEMIA AND WAYS OF ITS CORRECTION IN RHEUMATOID ARTHRITIS PATIENTS WITH METHOTREXATE TREATMENT

Sevara Mukhammadieva; Elnora Djuraeva; Nargiza Abduazizova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2439-2449

patients under 30. The control group consisted of 110 healthy middle-aged
individuals. In the surveyed population, those with 1 to 5 years of age were the largest group
(38.3%), followed by those with 5 to 10 years of age (34%). In 66.3% of the patients of RA MT
was used as a base preparation. The average dose (median) of MT over the study period was
10 mg per week. 80% of patients took prednisolone in an average dose of 10 mg/day. The
content of lipids in venous blood was determined by photocolometry on Vitros SYSTEM
Chemistry DT 60 biochemical analyzer (Austria). Results: RA patients who took MT showed a
significant increase in the level of triglycerides (TG). Also, it is characterised by an increase
in TG levels and a decrease in the concentration of high-density lipoprotein cholesterol
(HDL) and an increase in the atherogenicity factor. A more pronounced decrease in HDL
levels. Significantly high indicators of the atherogenicity coefficient, which to a lesser extent
depended on the duration of MT use. Low-density lipoprotein cholesterol (LDL) and
triglyceridemia are also proved to be serious risk factors for atherosclerosis and
cardiovascular heart diseases (CHD). Also according to the results of the research, special
attention is paid to the use of hypolipidemic drugs, which is promising in improving the
prognosis and reducing cardiovascular injuries in RA patients. In the group of patients who
received additional lipidex SR, there was a decrease in the level of OHS by 17.1%, an
important shift was observed on the part of TG, this indicator decreased by 29.7% and
practically did not differ from the control indicators. HDL cholesterol in the SR lipidex group
increased significantly by 37.7%. These fibrates have a stimulating effect on all components of

EFFICIENCY OF COMBINED APPLICATION OF APRICOT OIL AND AEVIT AS A REGULATOR OF LIPASE ACTIVITY OF BLOOD SERUM IN CHILDREN WITH VITAMIN D-DEFICIENCY RICKETS

Sh.M. Ibatova; F.Kh. Mamatkulova; D.S. Islamova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 787-796

In children with rickets, significant changes in the composition of higher fatty acids in blood serum have been established by gas-liquid chromatography. The depth of changes in the composition of higher fatty acids depended on the severity of the disease. The violated composition of higher fatty acids was corrected using vegetable (apricot) oil and aevit. Apricot oil helps to normalize the activity of serum lipase and leads to the restoration of the metabolism of higher fatty acids, the absorption of calcium and phosphorus thereby ensures high efficiency of therapy in children with vitamin D-deficient rickets. The effectiveness of this method of treating children before traditional therapy is shown.

JUSTIFICATION OF THE NEED FOR CORRECTION OF NEUROLOGICAL DISTURBANCES IN TREATMENT OF RESPIRATORY DISEASES IN CHILDREN.

Sharipov R.; Akhmedova M.M.; Rasulov A.S.; Dilmuradova K.R.; Rabbimova D.T.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2988-2995

In recent years, special attention has been paid to in-depth study of
perinatal lesions of the central nervous system, and this is not accidental,
since the problem of perinatal lesions of the nervous system has acquired
particular relevance in connection with the increase in the frequency of this
pathology. Perinatal brain damage accounts for more than 60% of all
pathology of the nervous system of childhood, is directly involved in the
development of diseases such as seizures, cerebral palsy, and minimal brain
dysfunction.

Diagnosis And Treatment Of Gastroschisis In Newborns

Ruzmatov Izzatbek Bakhtiyorovich; Ergashev Bakhtiyor Berdalievich; Sapaev Otabek Kadirovich; Atashov Aybek Raimberganovich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3853-3859

Objective: Optimization of diagnostics and treatment of gastroschisis in newborn infants.
Material and Methods: We observed 92 patients with gastroschisis. Among them boys - 51 (55,4%), girls - 41 (44,6%). Born full-term - 47 (51%), preterm - 45 (49%) children. On the first day (0-24 hours) after birth received 78 (84.8%) patients, 24-48 hours - 12 (13%) and 48-72 hours - 2 (2.2%) children.
Results: In 60 (65.3%) revealed a total form, in 27 (29.3%) and subtotal in 5 (5.4%) - a local form of gastroschisis. 51 (55.4%) of 92 children diagnosed prenatally pathology. Ultrasonographic findings of gastroschisis were uneven contours of the anterior abdominal wall, and the defect was located a short distance from the umbilical cord. In our studies, ultrasound accuracy in gastroschisis was 100%. Surgery performed 84 (91,3%) patients. 65 (77,4%) neonates with total, subtotal and local form performed radical surgery. In 17 (18.5%) cases made-stage surgical correction. Postoperatively, 52 died (61.9%) children. The most common cause of postoperative mortality were aspiration pneumonia, and sclerema oligoanuria as a result of hypothermia on the road and a painful shock and sepsis and necrotizing enterocolitis, cardiovascular and respiratory failure.

ULTRASONOGRAPHIC DIAGNOSTICS BY CHOOSING THE METHOD OF SURGICAL TREATMENT OF THE HABITUALDISLOCATIONOF THE PATELLA

Irismetov M. E; Rasulov M. R.; Rustamova U. M.; Ismatullaeva M. N.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1033-1038

Summary: The choice of the optimal method of surgical treatment of the habitual dislocation of the patella is one of the urgent problems of modern orthopedics. This is evidenced by the existence of more than 160 methods of operations. The ultrasound diagnostic method is non-invasive, affordable and quite informative, especially when choosing an operation. The article presents the results of ultrasound examinations to study the characteristic changes in the elements of the knee joint in this disease. A survey of 219 patients operated on using different methods was performed. According to the results of studies, it was found that ultrasonography is one of the methods for diagnosing the habitual dislocation of the patella, which provides the possibility of multiple dynamic studies and postoperative observation.

MANAGEMENT OF LE FORT II FRACTURE FRACTURE – A CASE REPORT

Dr. Vijay Ebenezer; Dr. Shanmuga priyan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 1559-1564

Lefort classification is the historic classification which is widely used to classify mid facial fractures. The lefort classification was given by Rene Lefort ,who classified mid facial fracture into Lefort I , II and III. Lefort 2 fracture is referred as ‘ PYRAMIDAL or SUBZYGOMATIC FRACTURE .’ Lefort 2 is a floating maxilla which runs from the thin middle area of the nasal bones down either side , crossing the frontal processes of the maxilla into the medial wall of each orbit . Within the orbit , the fracture line runs across the lacrimal bone behind the lacrimal sac to cross the infra orbital margin medial to or through the infra orbital foramen . Extends downwards & backwards across the lateral wall of the antrum below the zygomaticomaxillary suture & divides the ptyergyoid laminae .Le fort fractures are blunt trauma facial fractures which involves specific pattern of facial bones injury. Pterygoid process of sphenoid bones is involved in all Le fort fractures. Lefort fractures are classified further depending upon the involvement of zygomatic, nasal and maxillary bones. Blunt facial traumas due to motor vehicle collision, assault, falls or sports injury are the most common causes. In our case, Le fort 2 fracture resulted from motor vehicle collision.

COVID-19's Psychological Impact On Ophthalmologists In India

Dr.Anitha C; Dr. Suresh R

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5470-5475

To evaluate the psychological impact on ophthalmologists of the COVID 19 crisis during lock-ups in India. An online study was carried out during the lockout on ophthalmologists. The details collected included population information, address, current professional status, form of activity, marital status, effect on training or practises of COVID-19, and effect on income and living cost power. The Patient Health Questionnaire-9 measured psychiatric anxiety. Altogether 2,215 ophthalmologists replied. Multivariable research found that at younger age depression was considerably greater. For an age rise of 1 year, the risks of depression declined by 2.86%. Non-practicing ophthalmologists were more concerned about their schooling or professional development, in particular those with difficulties covering living costs. An extraordinarily significant number of ophthalmologists suffer from psychiatric disorders and will need customised psychological treatment of health

RECONSTRUCTION OF ORBITAL FLOOR FRACTURE– A CASE REPORT

Dr. Vijay Ebenezer; Dr. Wasim Ahamed

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 1614-1618

Orbit is a conical cavity in which the base lies anteriorly and the apex directed at Optic Foramen .By Age of 5 years orbital growth is 85% complete, finalized between 7 years of age. Orbit is formed from 7 bones (Maxillary, Zygomatic, Frontal, Ethmoid, Larimal, Palatine, and Sphenoid ). It consists of Four Walls – roof, lateral, medial, floor .Medial wall and floor are thin ,While Lateral wall and Roof are Stronger. Floor of orbit is weakened due to infraorbtal Canal passing through it. In Pure blowout fracture one orbit wall is affected, without involving orbital rims. The inferior and medial walls are affected most frequently. Clinical features are diplopia, infraorbital nerve paresthesia , entrapment of soft tissue within the maxillary sinus, restriction of ocular movements and enophthalmos. CT scan is most helpful method for diagnosis of orbital fracture. For orbit reconstruction, natural and synthetic materials are available. We report a case of 21 years old man, diagnosed with orbital floor fracture after slip and fall from his two wheeler The surgical treatment involved orbital floor reconstruction with titanium mesh under general anesthesia. The outcome was satisfactory and during followup visual disturbances or paresthesia was not present.

Improvement Of Treatment Protocols Of Pain Syndrome In Patients With Chronic Brucellosis

Zafar Z. Aminov; Sohiba Z. Khakimova; Salim S. Davlatov

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2540-2545

Despite the fact that brucellosis is a particularly dangerous, socially significant endemic infectious disease, to date, there are very few published scientific research on complex treatment, taking into account the pathogenetics of the disease.
Materials and methods. The data of 52 patients, with a diagnosis of chronic brucellosis accompanied by pain syndrome, were analyzed. Based on the received treatment, all patients were divided into 3 groups. The dynamics of treatment was evaluated by laboratory tests, and the perception of pain was evaluated by a 10-point visual analogue scale.
Results. The analysis showed that in all groups there was a positive trend, but the trend of the dynamics was different. The highest rate of improvement in the general condition of patients and reduction of pain was observed in the third group (p-trend<0.0001), which received B vitamins, along with antibiotic therapy and non-steroidal anti-inflammatory drugs (NSAIDs). A lower rate of improvement was observed in the group of patients receiving antibiotic therapy and NSAIDs.
Conclusions. Treatment of chronic brucellosis should be rational and comprehensive, taking into account neurological symptoms, the course, the nature and severity of the pain syndrome. It is advisable to prescribe vitamins of group B, along with NSAIDs and antibiotics, to provide a more rapid improvement in the general condition of the patient.

Optimization of the diagnosis and treatment of early neurological complications in cardio embolicstroke

Dilbar T. Khodjieva; Zarnigor . Nurova; Nodir K. Khaydarov; Dildor K. Khaydarova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5788-5792

Acute ischemic damage to neurons during the development of a focus of cerebral infarction (CI) is based on a complex cascade of interaction between the endothelium of the vascular wall, hemostatic factors, neurons and microglia. Oxygen starvation of tissues stimulates the production of endothelial cells of endothelial dysfunction markers produced by blood vessel endotheliocytes, macrophages, neurons and neuroglia in response to hypoxic brain damage. The so-called “cell death genes” are activated, which are responsible for the development of apoptosis, or programmed death of ischemic penumbra cells, as a result of the expansion of which the infarction volume increases

Review Article On Treatments & Preventions Of Hemorrhoids

R. RAMANI

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 6096-6099

This review discusses the pathophysiology, epidemiology, risk factors, classification, clinical evaluation, and current non-operative and operative treatment of hemorrhoids. Hemorrhoids are defined as the symptomatic enlargement and distal displacement of the normal anal cushions. The most common symptom of hemorrhoids is rectal bleeding associated with bowel movement. The abnormal dilatation and distortion of the vascular channel, together with destructive changes in the supporting connective tissue within the anal cushion, is a paramount finding of hemorrhoids. It appears that the dysregulation of the vascular tone and vascular hyperplasia might play an important role in hemorrhoidal development, and could be a potential target for medical treatment. In most instances, hemorrhoids are treated conservatively, using many methods such as lifestyle modification, fiber supplement, suppository-delivered anti-inflammatory drugs, and administration of venotonic drugs. Non-operative approaches include sclerotherapy and, preferably, rubber band ligation. An operation is indicated when non-operative approaches have failed or complications have occurred. Several surgical approaches for treating hemorrhoids have been introduced including hemorrhoidectomy and stapled hemorrhoidopexy, but postoperative pain is invariable. Some of the surgical treatments potentially cause appreciable morbidity such as anal stricture and incontinence. The applications and outcomes of each treatment are thoroughly discussed.

Radicular Pulp Therapy for the Primary Dentition

Dr. Sanat Kumar Bhuyan; Dr. Ruchi Bhuyan; Akankshya Sahu; Abhisek pati; Sidhant Bhuyan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1183-1189

Objective: The aim of this research was to screening the radicular pulp therapy for the primary teeth. Materials and methods: There were two different clinical procedures were used in this study one was single visit and another one was multiple visits. Out of those two single visits was more preferable. Various methods were also used to determine the working length of the teeth. Results: We found normal and healthy soft tissue after the treatment. No pathologic resorption associated with bone rare fraction also seen. Radiographic treatment was successful without evidence of bone reabsorption and no periapical radiolucency formation postoperatively. Conclusions: Pulpectomy is meant to protect the main teeth that are missing. The pulpectomy technique consists of debridging and widening canals with graded files in advance of shuttering.

Systamatic Review On Treatment Of Coronavirus

Dr.Eswari V; Dr.Maunika M

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5571-5575

Coronavirus-2 (SARS-CoV-2) causes extreme acute respiratory syndrome (SARS) and vascular injury, micro-angiopathy, angiogenesis and widespread thrombosis. The first symptom of the common cold is upper respiratory tract infection. Currently, there is no precise cure for the SARS-CoV-2 infection. COVID-19 reviews numerous prescription drugs used in global economy, which includes antiviral agents, inflammation suppressants, low molecular weight heparins, plasma, and hyperimmune immune globulins. Clinical researchers are using and investigating various ways of handling the virus. This article explores SARS-CoV-2 drug therapy along with other prescription medicines. The article will do the review of the literature done by the authors about the treatment of the coronavirus.

AWARENESS OF DENTAL PULP STEM CELLS AMONG COLLEGE STUDENTS

Shilpa Merlyn Jose; A.Jothi Priya; Lakshminarayanan Arivarasu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2268-2278

Stem cells are undifferentiated or partially differentiated cells which differentiate into various cells and can divide indefinitely to more or less the same type of stem cells. Dental pulp stem cells (DPSCs) are used to treat diseases like leukemia, lymphoma and spinal cord injury, heart failure, loss of hearing, blindness and vision impairment. DPSCs also have the capability to form clones of dental-pulp like cells. Due to its capability of changing into neural cells it can also send impulses to the brain. A well structured questionnaire containing socio-demographic information, knowledge, attitude and perception was framed and circulated through online survey links. The results conclude that the awareness of DPSCs was good among college students . Some of them knew the therapies done using these cells but were not fully aware of its properties and thus further studies can be done to increase the awareness and knowledge of the use of DPSCs.

Assessment Of Maxillary Single Complete Denture Treatment In A Private Dental College: A Retrospective Study

A Paul; Ashok V; Deepa Gurunathan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 3192-3201

Aim: The aim of the study is to evaluate the frequency of the number of patients who undergo maxillary single complete denture in a private dental college, Chennai.
Materials and Methods: The data were reviewed from patient records in a private dental college from a particular time period of June 2019 to March 2020. The data collected was then tabulated in excel and exported to SPSS by IBM. The outputs were obtained through statistical analysis..
Results: The results obtained were based on age, the most common age groups found were 44- 49 years. Based on gender, the gender predilection was towards females. The total number of patients who were diagnosed was greater than the number of patients who underwent treatment ( 51.2%) Conclusion: Within the limits of the study, the maxillary complete dentures are the most prevalent in the female gender of the age group 44-49 years of age. The number of patients treated were less compared to the number of patients diagnosed with partial edentulous maxilla.

ORIGIN, EVOLUTION AND HISTORY OF COVID 19 - A REVIEW

Ganesh S,; Jothi priya .A; Lakshminarayanan Arivarasu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2222-2229

The coronavirus disease (COVID-19) is a highly transmittable and viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which arises in Wuhan, China and spreads all around the world. The Genomic analysis shows that SARS-CoV-2 is related to severe acute respiratory syndrome- like (SARS-like) bat viruses, so bats could be the possible primary reservoir for this disease. The intermediate source of origin is not known, the rapid human to human transfer has been confirmed largely. Most adults or children with COVID-19 infection are with mild flu-like symptoms and a few patients are in critical condition and develop acute respiratory distress syndrome, respiratory failure, multiple organ failure, even death of the individuals. The most commonly reported Symptoms are fever, cough, myalgia or fatigue,pneumonia, and complicated dyspnea,where's less common reported symptoms include headache, diarrhea, halmoprysis, runny nose, and phlegm producing a cough. Still There is no clinically approved antiviral drug or vaccine available for COVID-19.Few broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical trials, resulting in clinical recovery. The current review is about the history of covid 19.

COVID -19 VS HANTAVIRUS- A REVIEW

Obuli Ganesh Kishore. S; Jothi Priya. A,; Lakshminarayanan Arivarasu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2248-2254

There is a rapid surge in research in response to the outbreak of COVID-19 which has taken the lives of many people.A detailed structured review of the corona virus could bring about any development in the field of research concerning the discovery of vaccines it treatment methods for COVID-19.Another virus called the Hanta virus that had originated in China was another pandemic which was controlled in the initial stages itself. Different articles and research journals were selected, analysed and computed for better understanding. The collection and analysis of data was done in the year 2020. A review of the epidemiology,clinical features,diagnosis,symptoms and treatment of corona virus and Hantavirus could help in advancements in its field of research. Also the comparison of economical impacts in the world during the pandemic virus attack can also be helpful to be economically prepared to face the crisis and reduce the chaos. But certain limitations that come across in this review had to be rectified for a proper result.But this review can be used for any quick reference regarding these deadly viruses.

Knowledge About Esthetic Veneer Treatment For Enhancing Smile In Undergraduate Dental Students

B. MADHUMITHA; DR L KEERTHI SASANKA; DR R ABILASHA

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 3070-3096

Background: The most important feature in maintaining and improving a person’s esthetic appearance and self-esteem is only by an attractive smile. Smiling is the best method to influence people. The dynamic part of the face is the oral region, with tooth and gingival display during functional lip movement which is unique to an individual, people with ugly smiles develop a high risk of psychological problems. Esthetic dentistry was motivated by the growing accessibility of media and online information has been highly demanded by the patients and tooth color is also used for veneers. Aim: The main aim of this study is to assess the awareness about the esthetic veneer treatment for enhancing smiles in undergraduate dental students. Materials and method: A survey based questionnaire was done to assess the knowledge about the veneer treatment. A self designed 16 questions were framed and the responses were collected through google form app.Thedatas were statistically analysed by SPSS software. Results: Results were represented in the form of bar diagrams and 71% of the respondents are aware of veneer treatment. This study shows a high-level self-consciousness about the veneer treatment 76% of the students agreed that they can brush veneer, 63% were answered for porcelain veneer. Conclusion: The present study concluded that the undergraduate dental students are highly aware of the esthetic veneer treatment for enhancing smile.