Online ISSN: 2515-8260

Keywords : rat

The Histological effects of Methotrexate on the lungs of albino rats: An experimental study

Shatha Th. Ahmed; Ziyad Ahmed Abed; Eman ghanim sheet AL-hyali

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 1, Pages 1289-1296

Introduction: Despite its potentially pulmonary complications, Methotrexate (MTX) is widely utilized in the treatment of arthritis. Several studies reported development of various forms of lung disease in patients treated with MTX. The aim of this study is to investigate the adverse effects of MTX on the lung structure and the likelihood of recovery following MTX withdrawal. Materials and Methods: A total of 30 albino rats were studied in 3 different groups of ten rats. Group I was considered as control whereas group II (MTX treated group), received 5 mg/ kg subcutaneous MTX (SC) for 5 days. Lastly, group III (withdrawal group) received similar doses of MTX for the same duration but sacrificed 5 days after MTX withdrawal for lung dissection and histological examination. Results: The lungs of MTX treated rats demonstrated a significant increase in the inter-alveolar thickness with concomitant mononuclear cell infiltration linked with alveolar collapse and damage. After MTX withdrawal, the changes in pulmonary structure exhibited partial recovery. This in turns suggests that MTX-induced lung toxicity was to some extent reversible. Conclusion: MTX could result in pulmonary inflammation and alveoli damages, therefore, this study recommends regular examinations for MTX patients designed for early detection of interstitial pneumonitis.


Mamataliev A.R.; Khusanov E.U.; Korzhavov Sh.O.; Makhramkulov Z.M

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 1, Pages 2173-2177

In this work, the options for the topographic structure of the extrahepatic bile ducts were studied, compared with the portal vein and the own hepatic artery, different options for the location of the extrahepatic bile duct of a morphological nature. Consequently, a comparative study of the structural features of the extrahepatic bile ducts in mammals with and without a gallbladder and structural rearrangements of the extrahepatic bile ducts after cholecystectomy is an urgent scientific problem in theoretical and practical medicine.