Online ISSN: 2515-8260

Keywords : risk factors


Criteria for studying the risk factors for rickets and its effect on the level of 25 (OH) D in blood serum in children

Rasulova Nadira Alisherovna; Rasulov Alisher Sobirovich; Sharipov Rustam Xaitovich; Axmedova Maxbuba Maxmudovna; Irbutaeva Lola Tashbekovna

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2150-2153

Based on questionnaires and level of 25(OH)D in 466 children under 1 year factors for rickets was identified. Reliable factors were iron deficiency anemia during pregnancy, toxemia of pregnancy of the mother and the lack of vitamin D during first year of life of a child, lack of outdoor stay (less then 20 minutes per day), frequent colds, not effective traditional prevention of rickets vitamin D.

Oral squamous cell carcinoma: review of incidence and risk factors

Muhammad Azeem Yaqoob; Wan Muhamad Amir W Ahmad; Nor Azlida Alenng; Sami Aljahmi; Sayed Farooq Jalal; Ashfaq Ur Rahim

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 7967-7978

Globally, oral cancer is the sixth most common cancer and it is associated with a mortality
rate up to 50%. Oral cancer usually encompasses tumours derived from the lips, anterior
two-thirds of the tongue, buccal mucosa, hard palate, the floor of mouth, upper and lower
alveolar ridges, retromolar trigone, and sublingual area. An approximate age-standardized
to world population (ASR (W) for oral cavity and lip cancer according to the World Health
Organization (WHO) the topmost is South East Asia with incidence of 6.4 per 100000,
followed by Europe and East Mediterranean (4.6 cases per 100000), America (4.1 per
100000), Africa (2.7 per 100000), and Western Pacific area (2.0 per 100000).Oral
squamous cell carcinoma has multifactorial pathogenesis which includes smoking, alcohol
consumption, and HPV and others. Oral cancer has multifactorial etiology, mainly
smoking, tobacco, alcohol consumption, betel quid chewing and high-risk human
papillomavirus (HPV). Worldwide, the prevalence of HPV infection is 3% in oral cavity
cancer and has a significant role in the management of oral squamous cell carcinoma
(OSCC) as HPV-related oral cancers have shown better prognosis.
The risks of oral cancer in many developing countries had increased mainly by the habits
of using betel quid chewing, tobacco and alcohol consumption.Human papillomavirus is a
major concern and a public burden in a clinical setting all over the world. The sites
frequently involved in HPV related cancers are tonsils and base of the tongue.

THE RELATION BETWEEN ATTENDING GERIATRIC CLINIC and MENTAL DISORDERS in ELDERLY PEOPLE

Dr . Ahmed Abdulameer Ibrahim M . B . Ch . B; Dr . Jawad K . al-Diwan MBChB, MSs, DCN , FIBMS , FFPH.; Dr . Riyadh Al-Rudainy , MB , FICMS / CM3

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 366-374

This study was conducted to estimate the prevalence and distinguish kinds and related factors
of Mental Disorders among elderly people attending Geriatric Clinic, Baghdad, Iraq.
Methodology: A cross-sectional study conducted and a systematic random sampling technique
was used to select 320 elderly people. We collected data on basic demographics and associated
risk factors using a questionnaire filled through self-reported questionnaire. Mental disorders
(MDs) were defined according to Kessler Psychological Distress Scale (K10) with a cutoff score
of 20+. Accredited tools used by WHO were utilized to identify mental disorders kinds. Results:
The prevalence of MDs in the study sample was 24.4%. The prevalence of MDs types were:
Depression 16.6%, anxiety 12.8%, dementia 5.3%, substance abuse 2.5%, suicide thoughts
5.6%, and suicide attempts 2.5%. Logistic regression analysis was used to examine the
determinant factors of elderly MDs revealed the following significant factors: Aging, smokers,
living depends on others, loneliness and social isolation, visual impairment, economic state
deterioration, neglect and mishandling, and chronic diseases are the determinant factors of
elderly MDs. Conclusions: Mental disorders are wide spread among elderly people and
enhanced elderly mental health care services should be provided

SQUAMOUS CELL CARCINOMA IN YOUNGER POPULATION: A SYSTEMIC REVIEW AND META ANALYSIS

Dr. Swati Chaturvedi; Dr. Dilber Pareed K; Dr. Pranoti Hiralkar; Dr. Sai Subramanian; Dr. I Nalini Sailaja; Dr. Vikesh Kumar R Shah

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 7300-7307

Introduction: Squamous cell carcinoma (SCC)s specifically of the tongue usually is seen in the senile population with a long standing tobacco habit. But recently the trend has changed to incidence of TSCC in younger adults with no risk factors. Hence we aim to conduct a systemic review and metanalyse to assess the prevalence and risk factors of tongue carcinoma in the younger group of patients. Materials and methods: We conducted the search for the data from the online sources like the “EMBASE”, “Pubmed”, “Scopus” and other sources. Only human studies were collected. Terms searched were CBCT, microtomography, permanent teeth, and root canal morphology. The data extraction and meta-analysis were based on the PRISMA guidelines. Out of the 109 articles, only 23 were selected based on the inclusion and exclusion criteria. For the assessment of the risk factors and the variables the statistical analysi s was done keeping p<0.05 as significant. Results: we observed that most of the subjects were at ages 30-50 years. The majority of reports were <40 years of age. Almost equal gender distribution was seen. No association between the habits was seen in the younger adults.

FORECASTING EPILEPSY RISK IN CHILDREN BORN FROM PARENTS WITH EPILEPSY

Muslima Mambetkarimova; Dilfuza Ashurova; Yakutkhon Madjidova; Nadira Zakirova; Sherali Ergashev

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2375-2381

This article details the condition of newborn babies from mothers with epilepsy.
The frequency and nature of epilepsy in children born to mothers with epilepsy are
described. Risk factors for the development of epilepsy in children born to mothers with
epilepsy were determined.

FACTORS OF OCCURRENCE OF CHILDREN AT RISK AND THEIR PSYCHOLOGICAL CHARACTERISTICS

Miruktamova Feruza; Makhamatov Makhmud

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1688-1696

Abstract: The article is devoted to one of the most important problems of our time
— children whose behavior contradicts generally accepted social norms and rules, i.e.
from the point of view of the risk of their actions in relation to society. The principal
probability of leaving a teenager in the "field of deviance" is determined by the presence of
risk factors, the essence of which allows us to identify the quality of self-esteem, the level of
anxiety, aggressiveness and affillation as criteria for the development of social competence
of children at risk. The article discusses the concept of "children at risk", explains the
reasons for getting children into the "risk group". Also, the author describes the main
value orientations of this group, especially in the development of adolescents included in it.

Correlation Of Risk Factors For Preeclampsia With Blood Pressure And Proteinuria

Hidayati Ratna; Hayati Farida; Fuadah Z. Dina; Sari K. Melani; Ludyanti L. Nita; Ishariani Linda

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4710-4717

Background: Preeclampsia is related to the inability to adapt to the physiological changes of pregnancy that result in decreased maternal organ perfusion. This complex clinical syndrome in preeclampsia can affect all organ systems such as the hemodynamic system, kidney, retina, and blood chemistry, which is manifested by increased blood pressure and protein urine.
Purpose: This study aimed to determine the correlation of the factors causing preeclampsia with blood pressure and protein urine.
Methods: This correlational study using the 127 respondents, sampling purposive sampling techniques, the independent variable factor in preeclampsia (age, genetics, history of diabetes mellitus, history of hypertension), and the independent variable blood pressure and protein urine. The measuring instrument used is a sheet checklist and analyzed by Spearman rank.
Results: The results showed the risk of preeclampsia in the age factor of 40.9% occurred in the 28-35-year-old respondents; 100% of patients had no history/genetic preeclampsia, 100% of respondents did not have a history of diabetes mellitus, and 88.9% did not have a history of hypertension. Systole blood pressure increased moderately and high by 26.0% and 22.0%, while diastolic blood pressure increased moderately and high by 26.0% and 11.0%. Respondents had positive proteinuria of 52%. The results of the analysis are not found a significant correlation between the factors of age, genetics, history of diabetes, and history of hypertension with blood pressure and preeclampsia protein urine on respondents.
Conclusion: History of hypertension associated with blood pressure and proteinuria in preeclampsia. History of hypertension is related to the condition of the blood vessels that manifest hypertension and decreased renal function (protein urine). Therefore, it is recommended in women with a history of hypertension to control blood pressure and perform routine prenatal care during pregnancy to prevent further complications.

Prevalence and Risk Factors of Congenital Anomalies among the sick neonates of the Ladakh region of India

Mohd Murtaza; MdNiamat Ali; MahrukhHameed Zargar; Oliyath Ali

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 1083-1092

Congenital anomalies are the structural and functional irregularities at birth. In this progressive study, all the neonates who are admitted to the Neonatal Intensive Care Unit during the three year period from 1st June 2017 to 31 May 2020.
Aim: The study aims to examine the prevalence, type, and epidemiological factors of congenital anomalies among the population of Ladakh India.
Subject and methods: All the neonates during the study period were examined by pediatrics and questionnaire filled by the consent of the family. A total of 936 parents of neonates was agreed to participate in this study and among them, 524 are male neonate and 412 was female.
Results: Four and a half percent were diagnosed as being congenital malformed and the common system affected by congenital anomalies in the digestive system followed by the mucso-skeletal system. In this study, based on the logistic regression consanguineous marriage with OR of 9.862 (4.221; 23.041), P= <0.001, familial congenital anomalies in the family with OR of 17.008 (4.343; 66.606), P=0.001, an anaemic mother with OR of .124 (.029; .538). P = .005, Apgar score with .033 (.016: .067), P-value of <0.001 and paternal smoking with OR of 13.305 (5.558: 31.854) with P value of <0.001 had shown a very good significant correlation with the congenital anomalies.
Conclusion: The occurrence and distribution of congenital anomalies in Ladakh were reported. More active prenatal screening and the possible role of genomics study are major importance to uncovering the susceptibilities.

Analysis of Risk Factors for Tuberculosis in the Lake Coastal Area, Towuti District, East Luwu Regency, Indonesia

Nasra .; Arsunan, A. A .; Yahya Thamrin; Wahiduddin .; Ida Leida Maria; Nurhaedar Jafar; Rezki Elisafitri; Ahmad Yani

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 67-73

Background: Tuberculosis (TB) is still a global problem. The high incidence of TB is due to the less than optimal TB risk factor interventions. This study aims to analyze the risk factors for TB incidence in the coastal area of the lake, Towuti District, East Luwu Regency.
Methods: This study used a case-control design conducted in the coastal area of the lake, Towuti District, with a sample of 34 cases and 94 controls. Bivariate analysis and logistic regression were used to analyze the risk factors for the incidence of tuberculosis.
Results: The results showed that the significant risk factors for TB incidence were family history (OR = 13,920; 95% CI: 4,36–51,23), household contacts (OR = 3.04; 95% CI: 1.188–7,809), close contact (OR = 8.382; 95% CI: 2.969–24, 852), home ventilation (OR = 14.357; 95% CI: 1.585–669.82), income (OR = 2.609; 95% CI: 1.033–6.675) . Home ventilation is the most dominant risk factor for TB incidence in the coastal area of the lake in Towuti District.
Conclusion: TB disease control strategies based on risk factors need to be implemented in coastal areas.

Criteria for studying the risk factors for rickets and its effect on the level of 25 (OH) D in blood serum in children

Rasulova Nadira Alisherovna; Rasulov Alisher Sobirovich; Sharipov Rustam Xaitovich; Axmedova Maxbuba Maxmudovna; Irbutaeva Lola Tashbekovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 5, Pages 1730-1733

Based on questionnaires and level of 25(OH)D in 466 children under 1 year factors for rickets was
identified. Reliable factors were iron deficiency anemia during pregnancy, toxemia of pregnancy of the mother and the lack of vitamin D during first year of life of a child, lack of outdoor stay (less then 20 minutes per day), frequent colds, not effective traditional prevention of rickets vitamin D.

Features Of The Frequency Prevalence And Risk Factors For The Formation Of Glomerulonephritis In Children

Navruzova Shakar Istamovna; Turaeva Nargiza Karimovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 5319-5324

The authors conducted a study on the risk factors for glomerulonephritis in children. Some regional features of glomerulonephritis in children have been established: the frequency is significantly higher among rural children; comorbid forms predominate in the clinical picture; chronic glomerulonephritis prevails in the structure of renal diseases; in virus-associated glomerulonephritis, the role of aggressive risk factors is the pathological course of pregnancy (OR-2.45, CI 99%, P<0.001), operative delivery (OR-1.33, CI 95%, P<0.01), TORCH infection of parents (OR-1.93; DI 95%, P<0.01), ECD and atopic dermatitis in the child (OR-1.43; DI 95%, P<0.01), frequent SARS in the anamnesis (OR-1.09; DI 95%, P<0.01), hemorrhagic vasculitis (within the last 3 months) (OSH-1.17; CI 95%, P<0.01), insect Allergy (OSH-1.27; CI 95%, P<0.01), chickenpox (within the last 3 months) (OSH-1.06; CI 95%, P<0.01), hypothermia (OSH-1.24; CI 95%, P<0.01) and a severe history (OSH-1.36; CI 95%, P<0.01).

A Study to find Relationship Between Identified Depressive Cases with Causative Factor Among Postnatal Mother

Dr. Priyesh M Bhanwara Jain; Vamja Diptiben Nanjibhai

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 4289-4298

Depression in postpartum is a high prevalence psychiatric illness that is weakening. This thesis aimed at examining the preceding reports. We have stated that studies examining postpartum depression risks by searching the database, Scopus, PubMed, ScienceDirect, Update and Proquest, published in 2000-2015 papers on postpartum depression factors in Farsi and English have been reviewed. A mixture of keywords included postpartum depression and risk factors or obstetric history, social and biological factors. Search strategy The literature review indicated that postpartum depression risk factors were observed in the field of economic and social factors, obstetric and biologic history, mental illness style and history. Data can be used in this study to develop a screening method for women with a high risk and to develop preventive programmes.

Assessment of Risk Factors For Stroke In The Vertebrobasilar System And Their Impact On Rehabilitation

Bakhadirova Munisa Anvarovna; Mirjuraev Elbek Mirshavkatovich; Shadmanova Lola Abdudjalilovna; Bakhadirova Madina Olimkhanovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3100-3115

Relevance: The high prevalence, high risk of social maladjustment as a result of the consequences of acute cerebrovascular accident and, accordingly, one of the main causes of mortality gives cerebrovascular pathology a special status, as evidenced by numerous publications. the task was to identify in the studied patients the entire spectrum of clinical manifestations corresponding to the lesions of the brain structures supplied by the blood vessels of VBD and to determine the presence of a statistically significant dependence of clinical manifestations of COPD. As well as the identification of risk factors and their influence on the rehabilitation of patients with stroke in the vertebrobasilar system.
Patients with IS in VBD and COPD - 62 people (group I) - 29 men and 33 women aged 50 to 74 years (59.8 ± 5.8). Patients with IS in VBD - 64 people (group II). Of these, 31 were men and 33 were women aged 51 to 80 years (62.4 ± 5.4). All patients received traditional treatment in the most acute and acute periods of IS, patients with COPD received COPD treatment in parallel with traditional IS therapy. in group I, BMI averaged 29.3 ± 5.8 kg / m2, in men - 28.9 ± 6.3 kg / m2, in women - 29.9 ± 5.1 kg / m2 (the difference is not significant, p = 0.58), while 11 patients (17.7%) had a normal BMI, 1 patient (1.6%) had a body weight deficit, 26 patients (41.9%) had preobesity, 15 patients (24, 2%) had first degree obesity, 9 patients (14.5%) had second degree obesity. Accordingly, preobesity or obesity was recorded in 50 patients of group I (80.65%) (Figure 3.3)
And in group II, BMI averaged 28.7 ± 6.1 kg / m2, in men - 27.8 ± 5.7 kg / m2, in women - 30.1 ± 5.6 kg / m2 (the difference is not significant, p = 0.6), while 17 patients (26.6%) had a normal BMI, 3 patients (4.7%) were found to be underweight, 29 patients (45.3%) had preobesity, 8 patients (12 , 5%) had first degree obesity, 7 patients (10.9%) had second degree obesity. Accordingly, preobesity or obesity was recorded in 44 patients of group II (68.8%). In patients of group I, among the clinical manifestations of IS in PBS, ataxia prevailed, which occurred in 35 patients (56.5%), including hemiataxia, which occurred in 20 patients (31.3%). Paresis and paralysis of the limbs were detected in 31 patients (50%). Complaints about a subjective feeling of unsteadiness, instability in an upright position, and imbalance occurred in 25 patients (40.3%). Dysarthria also occurred in 25 cases (40.3%). Nystagmus was detected in 22 cases (35.5%), rotational dizziness (vertigo) - in 20 cases (32.3%), depression of consciousness - in 21 cases (33.9%). Symptoms such as hemianopsia and ophthalmoparesis occurred each in 14 cases (22.6%). Sensory disorders were detected in 12 patients (19.4%), autonomic disorders - in 8 patients (12.9%), diplopia - in 8 patients (12.9%), dysphagia - in 7 patients (11.3%) , aphasia and headache - 6 patients each (9.7% each), dysphonia - 7 patients (11.3%), confusion and visual agnosia - 4 patients each (6.5% each), respiratory failure - 3 patients (4.8%). There were also 2 cases (3.2% each) of amnesia, ignorance syndrome and a feeling of generalized weakness.

PREVALENCE AND RISK FACTORS OF DENTAL DISEASES IN PREGNANT WOMEN LIVING IN DIFFERENT REGIONS OF UZBEKISTAN

Suvonov K.J .; Adilov U.X .; Kuryazov A.K.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2863-2870

The aim was to study the prevalence and risk factors of dental disease development in
pregnant women living in different Uzbekistan regions. The prevalence and intensity of dental
caries among pregnant women are 1.3 times higher in the Urgenchdistrict of the Khorezm
region compared to the Kibray district of the Tashkent region. These figures increase with
each subsequent pregnancy. The same pattern is observed for periodontal and oral mucosa
diseases. The most significant medical and biological factors contributing to the development
of dental diseases in pregnant women were age, several pregnancies, intergenerational period,
course and terms of pregnancy, the presence of extragenital diseases. Among medical and
social risk factors, the most significant were education, living conditions, oral hygiene,
sanitary culture, and medical activity of pregnant women.

To Study About Depression And Its Prevention Among Postnatal Mother In Selected Area Of Ahmedabad City, Gujarat

Vamja Diptiben Nanjibhai; Dr. Priyesh M Bhanwara Jain

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 246-253

The disturbance of neuropsychological processes during pregnancy and parturition may cause postpartum depressions in vulnerable individuals. Pre-natal and psychological and instrumental needs are indicated to be poorly met in western society and this crisis can interfere with neurophysiological factors to undermine the functioning of maternal psychology. In relation to neuropsychological women's wellbeing in the time of the transition, the effects of developmental factors and psychological and physical stressors are addressed. The psychobiological shift from pregnancy to successful post-natal parenting, the reconstruction of family and job roles, can be assisted, disregarded and derailed in the environmental milieu. Determining how psychosocial factors impact the link between violence and postpartum depression (PPD) history. Women have received B48 hours of live-born child care from four urban hospitals in Utah. The history has been collected by self-reporting during enrollment of physical or sexual assault. There have also been collected psychosocial covariates, including stressors and depression. Pregnancy stressors were classified using the Pregnancy Risk Assessment System's "stressor" questions. A pre-defined Edinburgh Postnatal Depression Scale score of C12 for 6-8 weeks after partition was taken as the key result indicator. Psycho-social threats were widespread among 1,038 women tested: 11.7% violence history, pregnancy strainors–financial 49.1%, emotions 35%, partnership-associated 19.8%, and traumas 10.3% and history of depression 16.7%. Interestingly, the experience of violence was just one of women with a moderate degree of stressors. Missuse and pregnancy stressors are normal and affect the probability of PPD positive testing.

Hepatitis C Seroprevalence Among A Tertiary Hospital Based General Population In Northern India

Heena Sharma; Vasim Mahdi Zaidi; Dr.Gomty Mahajan; Suman Kumari

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4088-4094

Hepatitis C is a disease caused by enveloped, RNA virus belongs to Flaviviridae family. It causes inflammation of the liver that lead to liver cirrhosis and finally hepatocellular carcinoma. Its genome consists of open reading frame (ORF) codes for structural and non-structural proteins. The ORF have 5´ and 3´ UTR regions. Hepatitis C virus is cause of post transfusion hepatitis. Symptoms of HCV include fatigue, dark urine, belly pain, joint pain, itchy skin, sore muscles and jaundice. It is a blood-borne transmitted agent. Use of unsafe therapeutic injections also leads to HCV infection. Diagnosis of HCV infection can be done by various methods like Enzyme Immunoassay (EIA) and Recombinant Immunoblot Assay (RIBA). The aim of this study is to estimate seroprevalence of Hepatitis-C in both sexes and different age groups in hospital based general population. And to study the trends of HCV infections in a tertiary hospital located at Northern India.
A prospective study was conducted for four months (January-April) at Tertiary Hospital in Northern India. Total numbers of 1643 blood samples were screened for the presence of anti-HCV antibodies in patient’s serum. Samples were tested by HCV TRI-DOT rapid test. Positive samples were retested by SD BIOLINE HCV rapid test and confirmed by ELISA.Out of 1643, 102 (6.2%) samples were HCV positive. Among seropositive samples, 48 were males (2.9%) and 54 were females (3.2%). HCV seropositivity was shown by 40 IPD patients (2.4%), 52 OPD patients (3.1%) and 10 ICU patients (0.6%). Among departments, patients from Recovery showed (0.6%), General ward (1.0%), Private room (0.2%), Neurology lab (0.1%) and Emergency (0.3%) showed HCV seropositivity. On analyzing age-wise seropositivity, it was found that maximum seropositivity was seen in 30-40 years (2.9%) followed by >55 years (1.4%), 40-55 years (1.2%) and<30 years (0.5%). Analysis of patients on the basis of risk factors showed that 17 had history of surgical operation (1.0%), 18 had history of blood transfusion (1.0%), 6 had history of dental procedure (0.3%), 25 showed history of injecting drug use (1.5%), 21 used contaminated syringes (1.2%) and 15 patients was under haemodialysis (0.9%). Professional health worker should protect themselves while handling infected blood. Counselling and testing should be done for those who are at risk for infection.

Influence Of Excess Body Weight And Deficiency Of Vitamin D On The Clinical Course Of Uterine Myoma

Dinara Kh. Irnazarova; Dilchekhra K. Yuldasheva; Dilbar K. Najmutdinova; Dilrabo T. Kayumova; Fotima A. Atakhodjaeva; Gulmira A. Akhmedova; Dilfuza R. Sadikova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3317-3324

Uterine fibroids is the most common benign gynecological disease, the pathogenesis of which is not fully understood. We examined 152 women in the II clinic of the T ashkent Medical Academy. The saturation of the body with vitamin D (25 ( OH ) D ) and its relationship with concomitant obesity in patients with uterine fibroids and healthy women were studied . In less than half of women with symptomatic myoma, deficiency and severe deficiency of vitamin D prevails with concomitant obesity of varying degrees . Studying the relationship between vitamin D deficiency and excess body weight in this pathology makes it possible to predict the development of the disease, the nature of the course and the risk of possible complications.

Systematic Review And Meta-Analysis: Risk Factors Of Acute Kidney Injury In Major Abdominal Surgery

Emminarty .; Hasyim Kasim; Haerani Rasyid; Syakib Bakri; Andi Makbul Aman; Husaini Umar; Muh. Ilyas; Arifin Seweng; Gita vita soraya

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 944-952

Background and objective: Acute kidney injury (AKI) is a common complication in patients undergoing major abdominal surgery. Various recent studies reported an incidence of AKI after surgery ranging from 6.7 to 32%. Risk factors for AKI in this setting may be procedure-related factors, post-operative complications and several patient-related include age, gender, comorbid disease Diabetes Melitus (DM), Hypertension (HT), Cardiovascular disease (CVD), and physical status. This study aimed to explore the risk factors of AKI in major abdominal surgery
Methods: We conducted a systematic literature search from PubMed and Cochrane Library. We included articles describing AKI in the setting of major abdominal surgery, published from 2015 until now, and cohort study design. This review was registered with PROSPERO (CRD42020216405)
Results: From 478 articles, 4 articles met our inclusion criteria describing AKI outcomes in varied population 683-3751. Prevalence of AKI 8,8 %. Age patient risk AKI in major abdominal surgery with Mean difference was 3.04 (95% CI = 1.83-4.25; P <0.00001). Meta-analysis of the four studies showed that Male had a pooled Odds ratio (OR) of 1.79 (95% CI = 1.04-3.08; P = 0.04) , DM OR 1.64 (95% CI 1.36-2.03; P <0.00001), HT pooled OR 1.90 (95% CI = 1.30-2.78; P = 0.0009), CVD has an OR of 1.58 (95% CI = 0.91-2.75; P = 0.10), physical status ASA≥ 3 (The American Society of Anesthesiologists) score has pooled OR 1.70 (95% CI = 1.16-2.49; P = 0.007)
945
Conclusion: Risk factors of AKI in major abdominal surgery setting are higher significantly in male, and patient with comorbid disease DM and HT had a significantly high risk of AKI, as well as physical status score ASA > 3.

CORRELATION OF RISK FACTORS FOR PREECLAMPSIA WITH BLOOD PRESSURE AND PROTEINURIA

HidayatiRatna .; Hayati Farida; Fuadah Z. Dina; Sari K. Melani; Ludyanti L. Nita; Ishariani Linda

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 5, Pages 1017-1025

Background: Preeclampsia is related to the inability to adapt to the physiological changes of pregnancy that result in decreased maternal organ perfusion. This complex clinical syndrome in preeclampsia can affect all organ systems such as the hemodynamic system, kidney, retina, and blood chemistry, which is manifested by increased blood pressure and protein urine.
Purpose: This study aimed to determine the correlation of the factors causing preeclampsia with blood pressure and protein urine.
Methods: This correlational study using the 127 respondents, sampling purposive sampling techniques, the independent variable factor in preeclampsia (age, genetics, history of diabetes mellitus, history of hypertension), and the independent variable blood pressure and protein urine. The measuring instrument used is a sheet checklist and analyzed by Spearman rank.
Results: The results showed the risk of preeclampsia in the age factor of 40.9% occurred in the 28-35-year-old respondents; 100% of patients had no history/genetic preeclampsia, 100% of respondents did not have a history of diabetes mellitus, and 88.9% did not have a history of hypertension.Systole blood pressure increased moderately and high by 26.0% and 22.0%, while diastolic blood pressure increased moderately and high by 26.0% and 11.0%. Respondents had positive proteinuria of 52%. The results of the analysis are not found a significant correlation between the factors of age, genetics, history of diabetes, and history of hypertension with blood pressure and preeclampsia protein urine on respondents.
Conclusion: History of hypertension associated with blood pressure and proteinuria in preeclampsia. History of hypertension is related to the condition of the blood vessels that manifest hypertension and decreased renal function (protein urine). Therefore, it is recommended in women with a history of hypertension to control blood pressure and perform routine prenatal care during pregnancy to prevent further complications.

ANALYSIS OF THE SUBTYPES OF ISCHEMIC STROKE IN YOUNG AGE

Kim O.A .; Dzhurabekova A.T .; Shomuradova D.S .; Shmirina K.V .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2509-2514

Abstract: Objective: to study the risk factors, clinical and pathogenetic features for the
subtypes of ischemic stroke at a young age in a comparative aspect. During 2017-2019, 74
patients with ischemic stroke (IS) or transient ischemic attack (TIA) were under
observation, 48 men and 26 women. All patients were divided into 2 groups: I-st (main)
group included 33 patients aged 20 - 44 years (aged of 40.5 ± 3.1 years); II-nd
(comparative) group - 41 patients age group over 60 years (aged of 67,9±3,9 years).
According to the TOAST criteria, a stroke of an unknown etiology occurred in young
people (49%), in old-aged - cardioembolic (39%) and atherothrombotic subtypes (31%).
Among the risk factors for ischemic stroke in young people revealed a combination of bad
habits, and in the old-aged category, such modulated factors as arterial hypertension, 2nd
type of diabetes mellitus, hypercholesterolemia are revealed. These findings confirm the
urgency of the problem of cerebral infarction of a young age and the need for further
implementation of the latest examination methods and a deeper study of the cardiovascular
system.

CHALLENGES FACED BY CHINA ON COVID-19

Hiranya . S; A.Jothi Priya; V.Vishnu Priya; Lakshminarayanan Arivarasu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2230-2235

COVID-19 disease is caused by coronavirus, a dreadful virus which affected China on December 19 in the city of Wuhan .In humans , these viruses cause respiratory tract infections that can range from mild to death.Most people infected with this virus have mild to moderate respiratory illness. This dreadful disease is caused by Severe Acute Respiratory Syndrome.Older people and those with underlying medical problems like cardiovascular disease,diabetes,chronic respiratory disease, and cancer are more likely to develop serious illness.The spread of disease is rapid from one country to another.In most of the studies it is being told that the death rates are increasing due to coronavirus.There are no vaccines or antiviral drugs to prevent or treat coronavirus. To review the challenges faced by china on covid19. The literature review is planned using a database like pubmed from the years 2015-2020 to know about the challenges faced by China

PREVALENCE AND RISK FACTORS ASSOCIATED WITH ORAL CANCER

Yandeti Srinivasulu; Abdul Wahab; Senthil Murugan.P

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1006-1015

Oral cancer is one of the most common major debilitating diseases affecting the world community.It is one the most commonest form of cancer in south asia especially countries like India,pakistan,bangladesh are most affected.This occurs mainly due to habits like smoking,gutkha and paan chewing and areca nut.most of people affected were between age groups third and sixth decades,so they are also prone for the systemic diseases.this will further complicate both the treatment plan,treatment.added to this, their postoperative complications and prognosis all depends on comorbid conditions like systemic diseases.so the aim of the study is identify the prevalence and risk factors associated with oral cancer .This is an Retrospective study.In this study a total 86000 patients records were analysed and after fulfilling the inclusion and exclusion criteria,a total of 53 patients from Department of Oral Oncology , Saveetha Dental College, who were diagnosed as oral cancer were considered for this study.Subjective and objective observations are recorded that includes age, gender, habits and systemic diseases of oral cancer patients. Period of study is from June 2019 to March 2020.All the datas of the patients were reviewed by an external reviewer and were tabulated.Statistics done with Chi Square test using SPSS.The results obtained in this study indicates that habits 39% and systemic diseases 45% were associated with oral cancer.Habits and systemic diseases are strongly correlated with oral cancer, these are risk factors for prevalence of oral cancer. Within the limitations of the study there are significant risk factors like habits and systemic diseases that are associated with the causation of oral cancer which has direct implications on the severity of disease and this will also enable us to pave the way for providing better comprehensive treatment for oral cancer.

KNOWLEDGE, PREVALENCE AND RISK FACTORS OF ANAEMIA AMONG PREGNANT WOMEN

Sharwini Baskar; Karthik Ganesh Mohanraj; Preetha. S

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 748-763

Pregnancy has some physiological changes which complicate the process of diagnosis and treatment. Over 200 million people suffer from anaemia especially among women of reproductive age. Anaemia is a major health problem among pregnant and non-pregnant women. Anaemia during pregnancy is considered as a public health problem especially in developing countries. The World Health Organization (WHO) defined anaemia during pregnancy as a haemoglobin concentration of less than 11g/dl. In severe anaemia, the haemoglobin level is 6g/dl. Anaemia threatens both mother and foetus. The causes may be multifactorial, such as nutrient deficiency, parasitic infections or chronic infections. It may also be due to acute blood loss. It may also depend on geographical location and economic status. The effects of anaemia on mothers are tiredness, weakness, dizziness and affects the immune system. In children, it may cause preterm delivery, low birth weight. On both the mother and the fetus it can cause mortality and morbidity. Intake of balanced diet and awareness programmes on anaemia is a measure to prevent anaemia. This study is to evaluate the awareness and prevalence of anaemia among pregnant women. A cross-sectional survey was conducted containing a set of self-developed questionnaires. The data was collected and analysed using SPSS software. The results are analysed and tabulated. The result was gained as follows, 25% of the participated population‟s haemoglobin level is less than 11, 75.89% of the population participated are aware that anaemia can affect pregnant women, 66.07% of the population agree that haemoglobin level less than 11 can cause anaemia. From the study, it is obvious that there is an awareness between the effects of anaemia during pregnancy.