Online ISSN: 2515-8260

Keywords : Skimmianine

Toxicological Characteristics Of Skimmianine Under Chronic Administration In White Rats

Sanoev Zafar Isomiddinovich; Mirzaev Yuriy Rahmanovich; Yakubova Lutfiya Karimdjanovna; Rakhimova Nigina Furqatovna; Pardaboev Oybek Bahodirovich; Berdimurodov Botirali Po’latovich

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 302-307

In chronic experiments in laboratory animals, studied toxicological perspective new antidepressants Skimmianine for the treatment of depressive states, an original herbal preparation based on Haplophylum perforatum was created. During 6 months of intragastric administration in animals exposed to all doses of skimmianine, no deviations in the parameters of the functioning of the nervous system were found, therefore, this value is the lowest effective (threshold) dose in a chronic experiment.