Online ISSN: 2515-8260

Keywords : Ascorbic acid

The Association between Uric and Ascorbial Acid Serum and Lichen Planus Pathogenesis

Sara Mohamed Mohamed; Sahar Mohamed Abd El fattah; El-Sayed Mohamed Galal; HodaAbdeen Ibrahim

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 489-494

Background: Lichen planus (LP) is a common disorder whose etiopathogenesis is not clear.Recently, it has been suggested that increased reactive oxygen species (ROS) play important roles in the underlying mechanism of LP. Free radicals have an important involvement in the underlying mechanism of lichen planus and also various skin diseases. The aim of the study was to evaluate serum uric acid (UA) levels as a measure of the antioxidant defense status in lichen planus patients.
Methods: A case control study was performed on 17 patients with lichen planus and 17 healthy subjects as a control group. We estimated Serum level of uric acid and ascorbic acid using ELISA.
Results: The mean of serum levels of uric acid and ascorbic acid was lower in patient group compared to healthy group with no significant difference between the two studied groups.
Conclusion: Lichen planus pathogens are not specifically affected by antioxidants as uric acid and ascorbic acid. However, in addition to other interactive variables, the difference in the level of serum for these anti-oxidants between lichen planus patients and healthy subjectsalbight not important– may suggest their involvement.

Antioxidant Activity Of Pyrazolopyrimidine Derivatives

Huma khan; Dr. Sudha singh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 7959-7666

A novel series of substituted pyrazolopyrimidine derivatives have been synthesized from
substituted hydrazine derivatives and ethoxy (methylene) malanonitrile gives an
intermediate (5-amino-1- substituted phenyl pyrazole-4-carbonitrile) (1) which on further
react with formic acid, acetic acid/HCl and formamide gives series of (1-
substitutedphenyl)1H pyrazole [3,4-d] pyrimidine-4(5H)-one (2). The synthesized
compounds were characterized on the basis of IR, 1H NMR and Mass spectral data.
Furthermore, these newly synthesized compounds were screened for their antioxidant
activity by DPPH free radical scavenging method. Unfortunately none of the compound
shows antioxidant activity.