European Journal of Molecular & Clinical Medicine

cholesterol (HDL-C) are usually decreased. However, enough data assessing this relationship
is scarce in different literature commenting on kidney disease progression in patients having
chronic kidney disease
Aim: The present study was conducted to assess the correlation between the progression of
chronic kidney disease and serum high-density lipoprotein cholesterol levels to provide an
alternative to urinary albumin-creatinine ratio (UACR) measurement.
Methods:The present study assessed the relationship between the progression of chronic
kidney disease and serum high-density lipoprotein cholesterol levels in 542 subjects with
diagnosed chronic kidney disease. The primary and secondary outcomes assessed were a 50%
reduction in the estimated GFR (Glomerular Filtration Rate) from the baseline values or the
onset of end-stage renal disease (ESRD). The secondary outcomes assessed were the
development of end-stage renal disease.

Background:Oesophageal cancer is the eighth most common cancer and sixth in cancer
related mortality, worldwide. The current study was carried out to see the role of three
markers (P53, HER2, EGFR) in various oesophageal lesions, their association in cancer
progression and their role as tumour markers.
Materials and Methods: Study was conducted on 100 cases of oesophageal lesions
consisting of both neoplastic and non-neoplastic spectrum. Immunohistochemistry was
performed on all the specimens for three markers as per the set criteria and expression
of these markers was studied and scoring was done accordingly.
Results: Present study was conducted on 100 cases with oesophageal lesions both
neoplastic and non-neoplastic. Parameters like age, gender, family history, alcohol
intake, cigarette smoking and location of lesion in oesophagus were also studied.
Expression of P53, Her2, EGFR were studied using IHC.
Conclusion: P53, HER2 and EGFR show a strong association with EC and
premalignant lesions, the absence of their expression in normal oesophageal tissue and
non-neoplastic conditions, points out their role in development of EC and tumour
progression. Out of the three markers, P53 has the strongest association with EC. HER2
overexpression was more in case of EAC than ESCC, indicating its importance in
guiding further treatment. EGFR over- expression was noted in fewer cases.

A novel series of triazolylquinazolin-4-one derivatives have been synthesized and characterized by TLC, melting point, FT-IR, 1H NMR and mass spectroscopy data. The synthesized series of title compounds were subjected for docking studies using Schrodinger Glide software, evaluated for their potential to inhibit enzyme EGFR-tyrosine kinase followed by in-vitro anticancer activity by SRB assay method on HeLa, MCF-7, A-549 cell lines. The series of compounds shows anticancer activity probably by inhibiting the enzyme EGFR-tyrosine kinase.