Online ISSN: 2515-8260

Keywords : Paracetamol


A clinical study of post-operative analgesia with intravenous paracetamol versus dexmedetomidine in patients undergoing laparoscopic cholecystectomy

Dr. Santosh Kumar, Dr. Nandini CV, Dr. Salim Iqbal M, Dr. Renita Lincia, Dr. Harsoor SS

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1431-1435

Pain management, stable hemodynamics and early post-operative recovery are the new challenges in ambulatory surgeries. The literature rates post-operative pain in laproscopic cholecystectomy as mild to severe pain. Our objective is to assess the post-operative analgesia with intravenous paracetamol versus dexmedetomidine in patients undergoing laproscopic cholecystectomy.
Methods: After ethical committee clearance, 60 patients were randomly allocated into two groups after informed consent. Patients between 18-50 years, ASA 1or 2 were included and those on opioids, any anti-inflammatory drugs, and hypersensitivity to study drugs were excluded. Group D received intravenous dexmedetomidine 1μg/kg as bolus over 10 min followed by dexmedetomidine infusion at 0.25ml/kg/h (0.25ml = 0.5μg). Group P received 1 g intravenous paracetamol in 100ml solution of normal saline over 10 min followed by infusion of 0.25ml/kg/h of normal saline.
Results: Demographic parameters were comparable between the groups. Time for first rescue analgesia, and total doses of analgesia in 24 h in group D was 225.33±29.12 and 2.73±0.64 and in group P was 143.33±28.96 and 4.23±0.77 respectively with p value 0.001 which was statistically significant.
Conclusion: Dexmedetomidine loading dose 1μg/kg and maintenance dose 0.5μg/kg is a good anesthetic adjuvant for general anesthesia to reduce post-operative requirement of analgesia in laparoscopic surgeries.

ASSESSMENT OF EFFICACY OF PARACETAMOL IN CONTROLLING ANALGESIA DURING LABOUR: AN INSTITUTIONAL BASED STUDY

Pooja Namdeo, Sonil Srivastava

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1661-1665

Background: The present study was undertaken for assessing the efficacy of paracetamol in controlling analgesia during labour.
Materials &Methods: A total of 50 pregnant subjects were enrolled. All the subjects were broadly divided into two study groups, with 25 patients in each group, as follows: Group A: Patients received IV Paracetamol, and Group B: Patients received matched placebo.  The course of events was studied and decrease in intensity of pain if any during labour was accessed by visual analog score and fetal outcome (i.e., notice Respiratory, APGAR score at 1 min to 5 min after birth). The VAS consists of a 10-cm horizontal line anchored at one end with the words “no pain” and at the other end with the words “worst pain imaginable.” All the results were recorded in Microsoft excel sheet and were analysed by SPSS software. Chi-square test and student t test was used for evaluation of level of significance.
Results: Mean VAS after 30 minutes among subjects of Group A and Group B was 6.25 and 7.13 respectively. Significant results were obtained while comparing mean VAS after 30 minutes among subjects of the study group and the control group. Mean VAS after 60 minutes among subjects of Group A and Group B was 6.12 and 7.96 respectively. Significant results were obtained while comparing mean VAS after 60 minutes among subjects of the study group and the control group.
Conclusion: Intravenous infusion of acetaminophen during labour assists in relieving labour pain without any maternal and fetal adverse effects.

A critical review on electro-analysis of clinically important drug Paracetamol

Mamta Latwal

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2763-2772

Paracetamol have been extensively used in both the human and veterinary clinics due to its
antipyretic and analgesic properties.It is considered as a well-tolerated drug in patients
suffering from aspirin intolerance, ulcers, or difficulty in blood clotting. It is very important to
monitor the doses of paracetamol in the patient’s body under examination since the overdose
results in accumulation of toxic metabolites which may cause severe adverse effects. Due to a
wide use of paracetamol and the adverse effects of its over dose, it is alwaysbeing an
interesting issue to develop suitable techniques for its quantitative as well as qualitative
analysis. The development of simple, convenient, highly sensitive, versatile, fast and economic
techniques is very necessary to control the over uses of this drug causing many side effects.
Various techniques used for the determination and detection of paracetamol have been
reviewed in this paper predominantly focusing on electro-analytical methods.