Online ISSN: 2515-8260

Keywords : Myocardial infarction


Renal Protective Effect of Vitamin D3 in Isoproterenol-Induced Myocardial Infarction in Rats.

Akmal Ahmed Hassan Diab, MD; Khaled AbdelfattahAbulfadle, MD; Nourelhuda A. Mohammed, MD; Fatma NabilHashim

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 1928-1944

Acute kidney injury is a common complication of myocardial infarction (MI) and
scarce data were available on the effect of vitamin D3 on heart and kidney functions in MI. In
this study, we investigated the potential protective effect of vitamin D3 on cardiorenal
functions in isoproterenol-induced MI in rats and the possible mechanisms involved. It was
shown that in MI rats, there was a significant increase in serum levels of (creatine kinase
myoglobin binding, lactate dehydrogenase, creatinine, malondialdehyde, interlukin-6 and
tumor necrosis factor alpha) and urine levels of (total protein and albumin), with a significant
decrease in urine creatinine level, creatinine clearance and serum levels of [reduced
glutathione and 1, 25 dihydroxy vitamin D] in comparison with the control rats. On treatment
of rats with vitamin D3 prior to induction of MI, these changes were significantly improved in
comparison with the MI rats. Histopathological and immunohistochemical examinations of
heart and kidney in MI rats reflected the deterioration in their structures with presence of
marked apoptosis which were ameliorated on treatment of rats with vitamin D3 prior to
induction of MI. In conclusion, vitamin D3 has a protective effect on heart and kidney
functions in the rat model of myocardial infarction and this beneficial effect could be related
to its anti-inflammatory, antioxidant and anti-apoptoticactions

Renal Protective Effect Of Vitamin D3 In Isoproterenol-Induced Myocardial Infarction In Rats

Akmal Ahmed Hassan Diab, MD; Khaled Abdelfattah Abulfadle; MD; Nourelhuda A. Mohammed; MD and Fatma NabilHashim

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 1341-1357

Acute kidney injury is a common complication of myocardial infarction (MI) and scarce data were available on the effect of vitamin D3 on heart and kidney functions in MI. In this study, we investigated the potential protective effect of vitamin D3 on cardiorenal functions in isoproterenol-induced MI in rats and the possible mechanisms involved. It was shown that in MI rats, there was a significant increase in serum levels of (creatine kinase myoglobin binding, lactate dehydrogenase, creatinine, malondialdehyde, interlukin-6 and tumor necrosis factor alpha) and urine levels of (total protein and albumin), with a significant decrease in urine creatinine level, creatinine clearance and serum levels of [reduced glutathione and 1, 25 dihydroxy vitamin D] in comparison with
the control rats. On treatment of rats with vitamin D3 prior to induction of MI, thesebchanges were significantly improved in comparison with the MI rats. Histopathologicalband immunohistochemical examinations of heart and kidney in MI rats reflected the deterioration in their structures with presence of marked apoptosis which were ameliorated on treatment of rats with vitamin D3 prior to induction of MI. In conclusion, vitamin D has a protective effect on heart and kidney functions in the rat model of myocardial infarction and this beneficial effect could be related to its anti-inflammatory, antioxidant and anti-apoptoticactions.