European Journal of Molecular & Clinical Medicine

Vitiligo is characterized by a disappearance of epidermal and/or follicular melanocytes which result in pale white patches on skin. It is an autoimmune disease and can develop at any age and in any gender. People affected by vitiligo can experience low self-esteem and concern about their appearance, leading to disturbed mental state and thereby affecting the quality of life. Methodology- The study was conducted at Sri Aurobindo Medical College and Post Graduate Institute, Indore, Central Research Laboratory and Department of Skin and VD, from Oct 2014 to April 2016. 84 patients who were known case of vitiligo were enrolled for the study. Written informed written consent was taken from all the patients. Detailed clinical examination was done on all patients to rule out other systemic disorders. 5ml of blood samples were collected in plain and EDTA tube from peripheral veins under aseptic precautions. Serum was separated by centrifugation of plain tube at 2000rpm.DNA isolation process was done.Results- The frequency of CC, CT and TT genotype of IL1b gene in our study was 27.4%, 48.8% and 23.8% cases and that were in controls were 28.8%, 43.8% and 27.4% respectively. Conclusion- No significant association of Il1b -511C/T polymorphism at genotype level was seen with the vitiligo

The MIG neurotherapy method, which is the most efficient method in the world to help treat diseases that have a nervous origin, or due to disorders in the nervous circuit and the exchange of nerve signals from the brain to the spinal cord, suffered serious injuries, and the MIG neurotherapy method will be able to treat brain, spinal cord and nerve injuries. , for the repair of neurons, myelins and nerves along with nutrition and related drugs for the treatment of brain, spinal cord and spine diseases.Oak fruit (in English: Acorns or oak fruit) is actually the nut or fruit of the oak tree, which is seen in the form of a cylindrical hazelnut. This fruit has a hard shell and has a cup on the top through which it is attached to the tree.in this study we investigate of effect of OAK fruit properties on skin and hair.

Background: Skin  is  the  largest  organ  of  the  body  and  various diseases  can commonly  involve  the  skin  out  of  which vesiculobullous  lesions  form  one of predominant  group. Histopathological study of bullous skin lesions andto knows the incidence of bullous lesions and to study bullous lesions in relation to age and sex.
Materials and Methods: A prospective study of vesiculobullous disorders were studied over aspan of 24 months from July 2019 to June 2021.  A total of 48 skin biopsies from patients with vesiculobullous skin lesions were sent to the Department of Pathology, Guntur Medical College, Guntur. Punch biopsies were taken for histopathological diagnosis. H& E staining was done.
Results: In the present study pemphigus foliaceus is the most common vesiculobullous disorder (35.41%) followed by pemphigus vulgaris in 18.75% of cases. Majority of patients presented between 31-40yrs of age with female prepondarance.  Subcorneal blister was noted in pemphigus foliaceus and suprabasal blister was seen in pemphius vulgaris.Dermoepidermal junction separation was seen in bullous pemphigoid, dermatitis herpitiformis, and bullous SLE.
Conclusion: Vesiculobullous disorders represent a heterogeneous group of dermatoses with female preponderance and peak incidence inthird decade. Pemphigus foliaceus constituted the most common subtype of vesiculobullous disorder in this study followed by Pemphigus vulgaris.

It has been estimated that in developed countries such as United States, plants drugs comprise
up to 25% of the total drugs, while in fast developing countries such as China and India, it
comprise up to 80%. It is expected that there are 250,000 to 500,000 species of plants on Earth.
Out of these small percentages (1 to 10%) are used as foods and medicine by both humans and
animal. It is possible that rest of plant may be used for foods and medicinal purposes.
Hence, it has turn out to be very important to review on herbal medicinewhich will play
important role in research on plant to find their possible medicinal importance.
Herbal formulations means a dosage form consisting of one or more herbs or processed herbs
in specified quantities to provide specific nutritional, cosmetic benefits meant for use to
diagnose, treat, mitigate diseases of human beings or animals, alter the structure or physiology
of human beings or animals. Herbal formulations contain an active substance or herbal
substance or herbal preparation or herbal substance in combination with one or more herbal
preparations. Herbal formulations are obtained by subjecting herbal substances to treatments
such as extraction, distillation, expression, fractionation, purification, concentration or
fermentation include comminuted or powdered. Whole, fragmented or cut plants, plants parts,
algae, fungi, lichen in an unprocessed, usually dried form but sometimes fresh were used in the
preparations of herbal formulations. Herbal substances are precisely defined by the plant part
used and the botanical name according to the binomial system (genus, species, variety and
author).

It follows from the data studied that information on the content of chemical elements in animal hair, depending on the presence of melanin, should be related to the concentration of this pigment, before judging the effect of environmental factors on their content. For a long time it was assumed that, the entry of mineral substances into the hair occurs from the blood capillaries, which are supplied to the hair follicle bulbs and the epithelial layers of the skin. There have been attempts to establish a positive correlation between the content of mineral and organic substances in the blood. When comparing the reaction of blood plasma and rat hair to a change in the composition of food, it was found that plasma quickly responds to changes in the content of magnesium and calcium in the diet, slowly - to the content of phosphorus and does not react at all to changes in the level of sodium and calcium (this is explained by a clear homeostatic regulation of the content of these elements in the blood). At the same time, the hair reacts quickly to changes in sodium content, slowly to calcium, magnesium, phosphorus, and very slowly to changes in potassium concentration.