European Journal of Molecular & Clinical Medicine

Objective:A systematic review of the existing literature was done to evaluate the effects oftherapeutic extraction of first and second premolar on mandibular plane angle and in turn on
the vertical facial dimension.
Methods: Electronic database searches (MEDLINE, EBSCO host and Google Scholar) of published literature were performed with no publication date or language restrictions followed by manual searches for eligible studies. Extraction of data was done independently and in duplicate by two authors.Risk of bias was assessed using Cochrane's tool, ROBINS-I (Risk of bias in nonrandomized studies – of interventions).