Online ISSN: 2515-8260

Keywords : lipids

Infertile Women Seeking Conception Through Assisted Reproductive Technology Have Different Lipid Profiles and Atherogenicity Indices

Subasis Mishra, Mousumi Acharya, Subhra Samantroy, Anamika Mishra .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 3204-3210

Infertility in women is common over the world, and lipid abnormalities are thought to play a role. The goal of this study was to determine the plasma lipid profile and atherogenicity indices among infertile women who visited assisted reproductive technology clinics. In 140 infertile women and 50 healthy age-matched women of proven fertility, the serum lipid profile (total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and computed indicators of atherogenicity) was assessed.Using reagents provided by Randox Laboratories, Crumlin, Antrim, UK, the lipid profile was determined using the spectrophotometric method. The unpaired Students' test was used to compare the mean values of measured parameters between cases and controls. Age (p<0.001), total cholesterol, triglycerides, low-density lipoprotein, AIP, certain cardiac risk ratios, and atherogenic coefficients were considerably greater (p<0.001) in infertile women than in control participants, but high-density cholesterol was significantly lower (p<0.001). The difference in mean BMI between the patients and controls was not statistically significant. Except for the high density/low-density ratio, all atherogenicity indices were considerably greater in infertile women seeking assisted reproductive technology for conception than in control participants. This group of people has greater atherogenicity indices, which may predispose them to cardiovascular disease. As a result, it is recommended that lipid profiles and atherogenicity indices be evaluated on a regular basis.


Dr Tariq Mohd Khan, Dr Shashi Paul, Dr Abhishek Sharma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11626-11632

Background: Although overt hypothyroidism is linked to lipid metabolic abnormalities, there are mixed results when it comes to the degree of lipid alterations in subclinical hypothyroidism (SCH).
Patients and Methods: In a cross-sectional investigation, the serum lipid parameters of 70 patients with subclinical hypothyroidism and 100 age and sex matched euthyroid controls were assessed.
Results: Patients with SCH had significantly higher mean serum total cholesterol (TC), triglycerides (TG), and very low-density cholesterol (VLDL) than controls (P<0.05). Patients with serum thyroid stimulating hormone (TSH) greater than 10 mU/L had higher mean TC, TG, and low-density cholesterol (LDL) concentrations than those with serum TSH equal to or less than 10 mU/L, although the difference was not statistically significant. The concentration of blood high-density cholesterol (HDL-C) and the amount of serum TSH had no correlation.
Conclusions: High TC, TG and VLDL were observed in our patients with SCH.


Randhir Singh, HarharpreetKaur,Jasdeep Singh Sandhu, Savita Kapila

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 781-788

BACKGROUND:Subclinical hypothyroidism (SCH) is defined as an elevated serum thyroidstimulating
hormone (TSH) level with a normal serum free tri-iodothyronine (FT3) & free
thyroxine(FT4) concentration. Hypothyroidism is associated with dyslipidemia and increased
risk of atherosclerosis. SCH can progress to overt hypothyroidism. Lipid profile changes in
SCH, however, are controversial.
AIMS AND OBJECTIVES: To study the lipid profile in patients with SCH.
MATERIAL & METHODS:The present study was a case-control study involving 35 individuals
with newly diagnosed / untreated SCH were studied. 35 age and sex matched adults with
normal thyroid profile were taken as controls. Serum TSH, FT3, FT4, Total cholesterol,
Triglyceride, Low density lipoprotein cholesterol (LDL-C), High density lipoprotein
cholesterol (HDL-C)and Very low density lipoprotein cholesterol(VLDL-C) levels were
measured in all study subjects.
RESULTS: The average total cholesterol and LDL-C in the patients with SCH in our research
were statistically significantly higher than the control group. The mean serum triglyceride,
HDL-C and VLDL-C levels were not statistically different in patients as compared to controls.
CONCLUSION: SCH is associated with dyslipidemia which is a risk factor for atherosclerosis,
with a resultant risk of cardiovascular disease and stroke. Thus, it is important to detect this
condition early so that appropriate steps may be taken to prevent its deadly complications

An evaluation of dyslipidemia in type 2 diabetes patients: North Indian teaching hospital based study

Dr. Gautam Gupta

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1020-1023

Background:Dyslipidemia was defined as a combination of high serum triglyceride ≥ 1.7
mmol/L, high serum LDL cholesterol ≥ 2.6 mmol/L and low serum HDL cholesterol <
1mmol/L for men and < 1.30 mmol/L for women. Non-HDL cholesterol ≥ 3.37mmol/Land
atherogenic index ≥ 0.11, were also considered abnormalType II diabetes mellitus (T2DM),
characterized by chronic hyperglycemia, and impaired insulin secretion and insulin
resistance. The objective of the present study was to study the lipid profile among type 2
diabetes mellitus patients.
Materials & Methods: The present study was conducted in the department of general
medicine. It comprised of 62 T2DM patients of both genders. Fasting blood sugar and lipid
profile such as serum cholesterol, serum triglycerides, HDL, LDL and VLDL was assessed.
Results and Observations:There were 31 males and females each. The mean serum
cholesterol level was 228.76 mg/dl, serum TG level was 202.6 mg/dl, HDL level was 39.8
mg/dl, LDL was 142.64 mg/dl and VLDL level was 43.5 mg/dl.
Conclusion: The diabetes has a significant role in alteration of lipoprotein levels. There is
significant alteration in lipid profile levels.

Correction OfEnergy Deficiency Condition In Calves With Prenatal Hypotrophy

Sergey Shabunin; Dmitry Savrasov; Yury Vatnikov; Eugeny Kulikov; Irina Bondareva; Elena Notina; Irina Bykova; Arfenia Karamyan; Olesya Petrukhina; Galina Frolova; Inna Pronina

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 1878-1889

The body of calves has high lability, the formation of its resistance and adaptive abilities are most expedient in the early stages of ontogenesis, but if the feeding, care, and maintenance conditions do not meet the requirements of the organism, animals are forced to adapt to these conditions, primarily due to increased energy costs. At the same time, the processes of all links of the metabolism are disturbed and the resistance to diseases decreases. The article presents the classification of antenatal hypotrophy of calves based on the criteria for assessing the state of clinical and zootechnical status and changes in the morphological and biochemical parameters of the blood of sick animals. A method for correcting the energy status of newborn calves with prenatal hypotrophy using carnitine chloride is described. Antenatal malnutrition is the pathology of the fetus, manifested by a violation of its development and arising as a pathophysiological reaction to an inadequate supply of the fetus with oxygen, nutritional and biologically active substances, or in violation of their digestibility. A comparative study of the effectiveness of the correction of metabolic disorders in calves with postnatal hypotrophy with a 10% solution of the transmitochondrial fatty acid transporter carnitine chloride at a dose of 100 mg/kg/day was carried out. The material for the study was the Holstein-Friesian calves from birth to 14 days. All calves were similar in age, body weight and were in the same conditions of housing, feeding, and care. Calves with signs of prenatal malnutrition were divided into 2 groups: experimental and control 6 animals each. The use of a 10% solution of carnitine chloride in hypotrophic calves restores the level of glucose, the main source of energy in the body, and inorganic phosphorus used for various phosphorylation processes to form adenosine triphosphate (ATP), stabilizes anabolic, transport, and catabolic processes, which together alleviate the condition of the newborn's body young with malnutrition. The recommended therapeutic approach leads to the stabilization of the energy-deficient state by optimizing the hemorrhological composition of the blood, the glucose content of the basic energy source in the body, and inorganic phosphorus used for various phosphorylation processes, reducing stress in the anaerobic metabolism system and forming reserve macroergic substrates. The implemented therapeutic measures allow, in the body of calves-hypotrophic, to restore nutritional status.


Dr.Meenal Vaidya,Dr. Vandana Varma,Dr. Sunil Singh Narwaria,Dr. Vibha Khare,Dr. Purnima Dey Sarkar, Dr Shiv Narayan Lehariya

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2787-2791

Background &Method: The aim of the study is to determine lipid status in one of the common neurodegenerative disease i.e Parkinson’s disease patients. 5 ml fasting blood samples from patients sex & age matched controls were collected from antecubital vein, with all aseptic precaution in plain vacutainers.
Result: Serum total cholesterol level and LDL cholesterol was significantly low in Parkinson’s patients as compared with control group. Serum HDL cholesterol level was slightly low, but not significantly different as compared with controls.
Conclusion: Finally from our work we observed that Serum Total cholesterol and Serum LDL cholesterol levels are significantly decreased, in Parkinson’s disease patients as compared with controls. Serum HDL cholesterol is slightly decreased & did not show any statistical difference in Parkinson’s disease patients as compared with healthy controls suggesting dysregulation of lipid metabolism in PD patients.