Online ISSN: 2515-8260

Keywords : hemodynamics


A COMPARATIVE STUDY OF TWO DIFFERENT ROUTES OF DEXMEDETOMIDINE ADMINISTRATION ON THE EFFICACY OF SUBARACHNOID BLOCK

Dr. Renuka R, Dr. Kayitha Sharanya, Dr. Nusrat Anjum, Dr. Dileep S, Dr.Vaishnavi Narendra Lakkappa

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 3050-3059

Background: Dexmedetomidine has emerged as a wonder drug in regional anesthesia practice owing to its co-analgesic properties. However, there is a lack of literature for comparison of intrathecal with intravenous routes of dexmedetomidine administration on the effectiveness of subarachnoid block.
Methods: Prospective, randomized, double-blind study was carried out in 40 patients aged 18-60 years with ASA I and ASA II physical status scheduled for elective infraumbilical surgery under subarachnoid block. Participants were randomly divided into two groups. Subarachnoid block was administered with 3ml of hyperbaric Bupivacaine in both groups. Patients in Group 1 received intrathecal 5µg dexmedetomidine and intravenous infusion of normal saline during surgery. Patients in Group 2 received intravenous bolus dexmedetomidine infusion of 0.5 µg /kg followed by maintenance infusion of 0.5 µg/kg/hr. Block characteristics, Ramsay Sedation score and hemodynamic variables were recorded for all patients.
Results: The duration of motor block, the dermatomal level achieved and duration of analgesia was higher in group 1 compared to group 2. The groups were similar with respect to onset time of sensory and motor block, sedation score and hemodynamic variables. There were no significant side effects in either of the groups.
Conclusions: Dexmedetomidine by either intrathecal or intravenous route is an attractive adjuvant for infraumbilical surgical procedures performed under subarachnoid block. In cases where the requirement is to prolong duration of intraoperative anesthesia and postoperative analgesia intrathecal route is desirable. Whereas, in daycare surgeries where the requirement is only to intensify the block in the intraoperative period with early postoperative ambulation intravenous route is preferable.

Hemodynamic indicators in pregnant women with obesity of various degrees of expression

Matlubov Mansur Muratovich; Muminov Abdukhalim Abduvakil; Khamdamova Eleonora Gafarovna; Yusupov Jasur Tolibovich

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2373-2380

Purpose: To study indicators of central and peripheral hemodynamics in pregnant women with obesity of varying severity at a gestational age of 36-38 weeks.
Materials and Methods: To study hemodynamic parameters (heart rate, SDD, UI, SI, OPSS, CR, LVMI) in pregnant women with obesity of varying severity, 127 pregnant women (I, main group) aged from 23 to 34 years were selected obesity of varying severity with gestational age 36-38 weeks. The second (control) group consisted of 28 pregnant women of the same age and gestational age with normal body weight (body mass index from 19 to 24.9 kg / m2). The groups were identical in age, gestational age, which allowed for an objective and comparative assessment.