Online ISSN: 2515-8260

Keywords : Disease severity


ANALYSIS OF BIOCHEMICAL MARKERS TO PREDICT DISEASE SEVERITY IN HOSPITALIZED COVD-19 PATIENTS, PUNE

Dr Charusheela R Gore, Dr Vinayak Sharma, Dr Sachin Shivnitwar, Dr Archana Buch, Dr Banyameen Iqbal .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 3234-3244

Background: Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), which causes coronavirus disease 2019 (COVID‑19), has swiftly grown into a pandemic. Despite extensive research, the function of numerous haematological and biochemical markers in prognosis remains unknown. There have been scientific papers in the Indian setting that describe demographics, clinical characteristics, hospital course, morbidity, and death in COVID-19 patients, however the numbers are limited. The current study provided us with a better understanding of the disease development and progression in COVID-19 patients, as well as the factors that determine disease severity.
Methods: This study was carried out at a COVID-19 tertiary care facility at Dr. D. Y Patil Medical College, Hospital and Research Centre, Pune. The demographic and clinical information, laboratory parameters of admitted COVID‑19 patients were collected were subsequently analysed.
Results: The mean (SD) age of COVID 19 patients was 48.21(16.37) years. The total number of COVID-19 patients with mild disease was 273 (45.27%), moderate disease was 177 (29.35%), and severe disease was 153 (25.37%). The Serum urea, serum AST, Serum total bilirubin, Serum Conjugated Bilirubin, Serum Unconjugated bilirubin , serum  LDH, Serum CRP and Serum Ferritin were differ significantly between mild, moderate, and severely ill  COVID-19 cases.
Conclusion: In conclusion the study revealed the role of numerous biochemical indicators in the severity of COVID-19, as well as the order of effectiveness among the markers. Our findings suggested that LDH and CRP levels were a promising biomarker for predicting COVID-19 severity.

THROMBOCYTOPENIA AND DISEASE SEVERITY AMONG COVID 19 PATIENTS

Dr. Divyarani M N , Dr. Manoranjan U D , Mr. Jagadish

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 3052-3057

Background: Thrombocytopenia in covid 19 patients were important for treatment and management of the disease. Main objective of the study was to assess thrombocytopenia and its association with disease severity among covid 19 patients. Methods: A cross-sectional study was conducted among 160 patients from April 2020 to December 2020.Sociodemographic and clinical data were collected. Thrombocytopenia has been implicated in patients infected with SARS Cov 2. Results: Among 160 patients, majority were males with mild severity. Platelet count were decreased in severe cases when compared to mild and moderate severity cases and found to be statistically significant(p<0.05).Conclusion: platelet count was an independent risk factor for COVID 19 patients.

Correlating inflammatory markers with clinical profile and final outcome in patients with Covid 19 admitted to a tertiary care setup

Dr. Mallikarjun HP,Dr. Ashwin DK,Dr. Ashitha B,Dr. Ramya Bhat S

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 2296-2303

Background: The ongoing worldwide Coronavirus Disease 2019 (COVID-19) pandemic has posed a huge threat to global public health1. COVID-19 represents a spectrum of clinical severity ranged from asymptomatic to critical pneumonia, acute respiratory distress syndrome (ARDS) and even death. Therefore, full monitoring the severity of COVID-19 and effective early intervention are the fundamental measures for reducing mortality.
Accumulating evidence has suggested that inflammatory responses play a critical role in the progression of COVID-19 3. Inflammatory responses induce the release of cytokines and chemokines. These cytokines and chemokines then attract immune cells and activate immune responses, leading to cytokine storms and aggravations4. Several inflammatory markers have some tracing and detecting accuracy for disease severity and fatality. But the results are inconclusive, with various studies giving different results. Our study intends to correlate levels of inflammatory markers with severity of Covid 19 infection and its final outcome.
Methods and materials:This is a retrospective study which includes 818 patients admitted to our hospital during the second wave of Covid 19 pandemic with confirmed Covid 19 infections by RTPCR. Admitted patients included mild disease to severe Covid 19 infections. Those patients who have received standardized treatment according to hospital protocol were included in the study. Data was collected and entered in pre-designed proforma. Results obtained will be compiled in excel sheet and will be analyzed statistically.
Results: Total of 818 patients were admitted to our hospital between May to July 2021. Of which 341 had mild disease, 241 had moderate disease, 237 patients had severe disease on presentation.While looking into the final outcome of the disease, 175 patients died due Covid 19 pneumonia or its complication, 52 patients were discharged with oxygen support.  Of 237 patients with severe disease 150 patients had CRP levels >75mg/dl. Of 175 patients who died, 121 had CRP levels >75 mg/dl. Of 237 patients with severe disease, 122 of them had D-dimer >1000 ng/ml. Of 175 patients who died with Covid 19, 103 of them had d-dimer levels >1000 ng/ml.CRP and D-dimer were significantly increased in patients with severe disease and in patients who died of Covid 19 with p value <0.0001.
Conclusion: Increasing levels of CRP and D-dimer were good predictors of severe disease in Covid 19. Also, increased levels of CRP and d-dimer were suggestive of poorer outcome of the disease in terms of mortality and morbidity in Covid 19 infection.

Impact of sex hormone fluctuations on functional health status and menopause rating scale among postmenopausal RA patients

Essam Tawfik Atwa; Hisham Mohamed Omar; Asmaa Amin Mohamed

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2390-2400

Introduction: Women with RA have higher grades of disease activity and more declines in health status than men with RA; this recommends a relationship between estrogen and disease activity and severity.
Aim: Our aim was to detect the effect of sex hormone fluctuations and menopause on functional disability and quality of life of postmenopausal RA patients.