European Journal of Molecular & Clinical Medicine

Background: Acne Vulgaris is widespread among teens. Acne isn't fatal, but it can be debilitating. Acne scarring can cause low self-esteem, social impairment, and rage.
Material and Methods: For the aforementioned study, 50 patients of either sex were enrolled and randomly assigned. The investigation was a single-blind, randomized, open-prospective clinical trial. It was conducted from September 2021 to August 2022, in the atDVL Dept., RVM Institute of Medical Sciences and Research Center, Laxmakkapally (V), Mulugu (M), Siddipet (D), Telangana- 502279, India.
Results:Many cosmetically aware teens about to marry sought treatment, however light. In this study, acne prevalence is directly related to sebaceous activity. 31% of patients had familial acne vulgaris. Acne is hereditary. 15% of women had pre-menstrual flare-ups attributable to pre-menstrual changes in pilosebaceous epithelium hydration.
Conclusion: This study found that men were more likely than women to have acne vulgaris. Regardless of gender, the age range of 15-20 years saw an increased incidence. In this study, it was shown that students had a noticeable incidence of acne vulgaris. The study's triggering elements were more prevalent in male patients.

Background:Acne vulgaris is a common inflammatory disorder involving the pilosebaceous unit. The
pathogenesis is multifactorial, involving four key factors with interrelated mechanisms: increased
sebum production, hyperkeratinization of the follicular infundibulum, inflammation, and
Cutibacterium acnes. Botulinum toxin (BoNT)is a potent neurotoxin protein derived from the
clostridium botulinum bacterium. It exerts its effect at the neuromuscular junction by inhibiting the
release of acetylcholine, which causes temporary chemical denervation. At the cellular level,
botulinum toxin functions by cleaving a synaptic protein (synaptosomal-associated protein of 25 kDA
[SNAP-25]) on the internal surface of neuronal membranes, thereby inhibiting vesicle fusion and
release of acetylcholine.

Background: Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that is associated with significant psychosocial repercussions. Chemical peeling is a documented option in the treatment of active acne. Glycolic acid belongs to the group of α-hydroxy acids is used as a superficial or medium depth peel in acne treatment Jessner’s solution (JS) peel is formulated by Dr. Max Jessner to minimize complication from resorcinol, namely contact
dermatitis. Salicylic acid also decreases in inflammatory lesions

Background: Acne, also known as acne vulgaris, is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin. It is characterized by blackheads or whiteheads, pimples, oily skin, and possible scarring. It primarily a Acne vulgaris is one of the commonest skin disorders which dermatologists have to treat, mainly affect adolescents, though it may present at any age. Acne is definite as multifactorial chronic inflammatory disease of pilosebaceous skin diseases are common, especially in the developing countries. Mental health disorders are prevalent among those with skin diseases and affect their life and their treatment. Anxiety is one of the psychiatric disorders, and its symptoms were found among the patients with skin diseases. effects areas of the skin with a relatively high number of oil glands, including the face, upper part of the chest, and back. The resulting appearance can lead to anxiety, reduced self-esteem and, in extreme cases, depression or thoughts of suicide.Acne vulgaris is a common condition extremely prevalent among teenagers and young adults under the age of 24 years. Nearly 85% of adolescents in this age group experience some degree of acneAcne vulgaris is a skin disease of chronic inflammatory nature. Although acne is not a life threatening, it has a deleterious impact on patients' social and psychological health.
Aim of the study:to assessment of Knowledge regarding acne vulgaris among secondary school students in Makkah.
Method:A cross-sectional study design. The current study was conducted Male and female secondary school students from selected governmental schools in Makkah. The total the sample size calculation will be 200 students. Female and male.
Results:Conclusion:Patients with dermatological diseases have a high level of anxiety and worry, especially with acne and skin disease affecting visible areas like the face. Further studies are required in Saudi Arabia to explore the true estimates of this problem.