European Journal of Molecular & Clinical Medicine

INTRODUCTION:
HPV infection is one of the most common sexually transmitted infections, affecting both the gender equally worldwide. Human Papilloma Virus (HPV) is a family of closely related non-enveloped a doublestranded DNA virus with currently more than 200 different sequenced genotypes.Two human papilloma virus types (16 and 18) are responsible for nearly 50% of cervical cancers. The India academy of paediatrics committee on immunization recommends offering HPV vaccine to all the female of appropriate age who can offered the vaccine. It is ideal that the vaccine is administered prior to the sexual debut to avoid the transmission of the virus and hence recommended, that age 10-15 should be vaccinated.
RESEARCH DESIGN AND METHOD:
A quantitative descriptive study was conducted to assess the level of awareness regarding HPV virus and acceptance level of HPV vaccination among study participants. The research was conducted in selected villages of Chengalpattu district among young girls and boys (10-15 years of age). Total of 300 study participants who met with the inclusion criteria were selected by convenient sampling technique. Two separate questionnaires were used to assess the knowledge and level of acceptance. Informed consent was obtained from all the participants and their parents

Sinonasal inverted papilloma (SIP) has a recurrent tendency and potential for transformation into squamous cell carcinoma and is a locally aggressive benign tumor. In the progression from benign SIP to malignancy, human papillomavirus (HPV) and epidermal growth factor receptor (EGFR) are suggested to play a major role. This work aims to assess their role as tumor marker in SIP. Immunohistochemical analysis for EGFR and PCR detection of HPV – DNA were estimated in nasal biopsies from 35 SIP, 35 NP and 30 control patientsv (turbinate surgery candidate). Serum SCCA1 was also assessed. HPV-DNA was detected as 63%, 8.6% and 0 % in SIP, NP, and control patients. EGFR intensity revealed statistically significant difference between SIP and other groups. Significant elevated serum SCCA level (6.14 ± 2.69 ng/ml) was found in SIP group, compared to 2.41 ± 1.12 ng/ml and 0.68 ± 0.25 ng/ml in NP and control group. There was a significant decrease of its level postoperatively. The sensitivity was 80.0 and the specificity was 93.8. These results may suggest SCCA and EGFR are possible reliable tumor markers in SIP monitoring and management. High prevalence of HPV-DNA points to its possible role as etiological factor for SIP.