Online ISSN: 2515-8260

Keywords : Regeneration

Stem Cell Regeneration: A Comprehensive Review

Dr. Smriti Kapur; Dr. Monika M Sehgal; Dr. Samar Grover; Dr. Kazal Sohi; Dr. Neha Rohilla; Dr. Jaskiran Sidhu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 6424-6431

Background: Teeth are an ectodermal organ that is derived from sequential reciprocal interactions between oral epithelial cells and cranial neural crest–derived mesenchymal cells. Human tooth‐ associated stem cell populations include dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), and stem cells from human exfoliated deciduous teeth (SHED), have been isolated from dental pulp and periodontal ligament tissues. Although dental stem cells possess colony formation, proliferation and multipotent differentiation capacity to generate osteogenic, adipogenic and chondrogenic lineages in vitro similar to BMMSCs under certain conditions, they also displayed their own distinctive regenerative potential different from each other in vivo, suggesting that tissue specific stem cells might be the optimal choice for self-tissues repair and regeneration.


Zevara Karimova; Yakshimurat Kurambaev; Zulkhumor Jumaeva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2463-2468

Abstract. More often, the injuries happenas a result of direct trauma, and are rarely
caused by non-direct actiontraumatic force. The definition of tarano-calcaneus corner and
higher index (rentgenological) has great influence on diagnostics and on curing calcaneus
bones in children.On moderate displacement, closed reposition with the skeleton stretching
or compression apparatus distinction osteosinthesis is recommended.On crude
displacement, it is recommended to perform operative treatment and replace defects of
bones bytissues free auto-transplantation

Liver Micro-Circulator Back After Its Partial Resection For 15 Day Of Life

Askarov T. A.; Olimkhujayev F. Kh.; Akhmedov M. D.; Fayziev Y. N; Ashurmetov A. M.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 4099-4106

In an experiment on 180 white mongrel male rats, 31-34% (left lateral lobe)
of the liver was resected on the 15th day of life. We found that after resection of the liver,
constantly occurring liver complexes were detected, which consist of 3 types of lobules. The
initial link of blood outflow from the hepatic lobes is the initial hepatic venules, which are
formed from the fusion of sinusoids in the subcapsular zone of the liver. After resection,
the main process is the formation of new structural and functional units – liver lobes in the
subcapsular area of the organ.

Stem Cells Harvested From Exfoliated Deciduous Teeth - A Review

KiranSrinivas B; Gifrina Jayaraj; YuvarajBabu K

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2888-2899

Stem cells harvested from exfoliated deciduous teeth are a type of mesenchymal cells, serving its main purpose for regenerative treatment. They have lots of clinical applications. They are studied for their distinct proliferative properties. It helps in regeneration of tissues in the site of an injury and also helps in reducing the healing time of an injury. It also serves as the research interest for many because of its easy source of availability, extensive regenerative capacity and multiple lineage properties. This article is in the narrative format of previous research articles on stem cells exfoliated from deciduous teeth, which discusses various complex procedures associated with SHED - like extraction, isolation, post extraction and banking of it mentioned from other articles as well. SHED has a lot of branches to be studied and understood deeply. So that they can be implemented for many human uses. It is used for future as well as diagnosis.


Mohamed Thameemul Ansari.K. A; Raghu Nandakumar; A.K. Anjali

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1834-1838

Stem cells are special human cells that can develop into any cell type of the organism if it's induced and have the ability to renew themselves under suitable conditions. Applications of stem cells exist in manyfields. A Review study is conducted to analyze and investigate dental Pulp stem cells and its application. Human pluripotent stem cells (either human embryonic stem cells or induced pluripotent stem cells) can differentiate into every cell type of the human body with infinite self-rentention capacity. Hence, pluripotent stem cells are an ideal source to generate specialized cell types for cell replacement therapy, e.g. beta cells for diabetics Nevertheless, due to a large number of differentiation steps, current protocols for in vitro cell differentiation are rather complex.. To regulate the cell growth and differentiation, almost 20 signaling proteins and small molecules last for more than four weeks. Not all cells differentiate into the targeted cells but take incorrect differentiation paths during this multistep process.. This can lead to a highly heterogeneous cell population with beta cells that are not fully functional. This paper reviews the recent studies and researches about dental pulp stem cells and their applications in the field of dentistry.


Niveda Rajeshwaran; GurumoorthyKaarthikeyan .; Priyalochana Gajendran

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1427-1439

The aim of the present study is to assess the current trends in antibiotic prescription for various periodontal flap surgical procedures among periodontists in Chennai. Retrospective data collection was conducted from June 2019 to March 2020 on patients who visited the outpatient department of Periodontics for multitude of flap surgical procedures. The type of flap surgery done and the antibiotic regimen prescribed were recorded. The data was tabulated using excel and SPSS software version 23.0 (Statistical Package For The Social Sciences) was used for descriptive statistics.The distribution of antibiotics after flap surgical procedure among the above mentioned groups were expressed in terms of percentage. Chi square test was done to assess the association between the study variables.Based on this hospital based assessment, it was found that the most commonly prescribed antibiotic was amoxicillin 500mg, followed by a combination of amoxicillin and metronidazole for flap surgical procedures like Open flap debridement, Resective osseous surgery and regenerative osseous surgery. The least preferred antibiotics were azithromycin and doxycycline.There was statistically significant association between gender and type of antibiotic given, with a higher percentage of males receiving a combination of amoxicillin and metronidazole than females. There was no significant difference between the antibiotics prescribed for patients who underwent Resective or regenerative flap surgery. Thus Amoxicillin is the most preferred, cost-effective and less toxic drug which acts against both aerobic and anaerobic microorganisms. However care must be taken in administering antibiotics in order to avoid misuse and overuse of antibiotics.


Ranjana V; Gifrina Jayaraj; Gayathri R

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1384-1394

Outermost covering of the teeth is dental enamel. Enamel is the hardest substance and highly mineralized tissue present in the human body which is almost 96%. It is formed by developing enamel organ epithelial cells called ameloblasts. The protein present in the enamel that helps in the mineralization process is Amelogenin. It is revealed that stem cells can be used for whole tooth regeneration and enamel regeneration but the main problem faced in fabricating cell free synthetic enamel is the formation of the complex interprismatic substance. The main aim of this review was to analyze and review on the various methods of enamel regeneration. This review was done based on the articles obtained from various search engines such as PubMed, PubMed central and Google scholar. They were collected with a restriction in time basis from 1997 - 2020. The inclusion criteria were original research papers, review articles, in vitro studied among various conditions and articles that contain pros and cons. Exclusion criteria came into account for retracted articles and articles of other languages. All the articles were selected based on Enamel Regeneration. The level of evidence of the reviewed articles were categorized as per the criteria of the centre for Evidence-Based Medicine, Oxford, UK. Enamel is the hardest mineralized tissue, which can withstand masticatory forces and gives protection to underlying dentin and pulp. Enamel cannot be regenerated since the ameloblast which forms the enamel, gets degenerated. Therefore, it should be preserved, as there is no material found to exactly duplicate it.