Online ISSN: 2515-8260

Keywords : Type II diabetes


Effect of Body Mass Index on Lipid Profile of Type 2 Diabetic Patients at an Urban Tertiary Hospital in Nigeria

K. Priyadarshini, Dr. Manila Jain

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 701-716

Introduction:Diabetes mellitus is an important global public health problem. In addition to being a chronic disease, obesity is a key risk factor for Type 2 diabetes mellitus (T2DM) that leads to disability. This study aimed at investigating the effect of Body Mass Index on serum lipid profile in type II diabetic patients.
 
Material and Methods
This is a prospective study and observational study will be done in the Department of Physiology in collaboration     with the Department of Medicine, Index Medical College, Hospital & Research Centre, Indore.Inclusion Criteria:Only Diagnosed cases of male and female Type II Diabetes Mellitus cases aged 30-60 suffering from more than 2yrs. The diagnosis of diabetes is made on the basis of (Revised American Diabetic Association criteria). Fasting glucose >126mg/dl and 2hr postprandial plasma glucose >200mg/dl.
 
Results: The mean (± SD) of various motor nerve variables like latency, amplitude and nerve conduction velocity between control and cases. When compared these variables between controls and cases was statistically highly significant (p<0.001). Comparison of various motor nerve variables like latency, amplitude and nerve conduction velocity between control and cases are graphically shown.
 
Conclusion: A significant negative correlation between BMI and HDL-C was observed, while the correlation between BMI and LDL-C was observed to be insignificant. HDL-C was found significantly higher in patients with normal BMI. These results are important to indicate that there is modest impact of BMI on lipid profile. Therefore, assessment and management for altered blood lipids should not be based on a patient’s body weight or BMI.

MEASURING the LEVEL of FUCOSE AND SOME ANTIOXIDANTS and MEASURING SOME BIOCHEMICAL VARIABLES in the BLOOD of PATIENTS with TYPE II DIABETES

Nuha ali Hadi; Abdulmonaim Hamad

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 105-110

The study aimed to find out the effect of type II diabetes on fucose and some values of antioxidants compared to healthy people, as 30 blood samples were collected from patients with type II diabetes, their ages ranged from 30-55 years, while 20 blood samples were collected from healthy people of the same age group and for both sexes., Where the fucose level was measured, a significant increase was found in the patient group by 0.01 compared to healthy people, and the efficacy of the enzyme catalase was measured, and a significant decrease was found at the probability level of 0.05. Also, glutathione recorded a decrease of 0.01 in patients with diabetes mellitus compared to healthy people, while vitamin C, Malondialdehyde and Peroxynitrite were recorded. An increase in the patient group compared to the healthy group at the 0.01 level. While vitamin A and Glutathione-S-transferase were increased in the group of patients compared to the healthy group, with the probability level 0.05. The study also included the measurement of urea, creatinine, uric acid and basic phosphatase. Urea, creatinine, and basic phosphatase all recorded an increase in the group of people with type II diabetes at a probability level of 0.01 compared to the healthy group, while uric acid recorded a significant decrease at the probability level 0.01. compared to healthy controls