Online ISSN: 2515-8260

Keywords : IgM


An Observational Study to Correlate the Clinical Profile with Laboratory Investigations and Radiological Findings in Dengue Fever at Tertiary Care Center

Ramesh Chand Sharma, Mamta Meena

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10467-10472

Background: The demographic pattern and the trend of disease (dengue fever) are
largely changing everyyear through the past decade.Early recognition and prompt
initiation of appropriate management is vital. The aim of this study to correlate the
clinical profile with laboratory investigations and radiological findings in dengue fever
at tertiary care center.
Materials& Methods: A cross sectional study done on 50 children less than 12 years of
age with clinical signs and symptoms of Dengue- any acute febrile illness in department
of Pediatrics, RUHS College of Medical Sciences, Jaipur, Rajasthan, India during one
year period. For all suspected dengue fever, the IgM ELISA qualitative test was done at
our hospital. Children positive for IgM dengue were taken up for study and followed up
for clinical profile.Labinvestigations carried out in these patients include CBC,
Haemoglobin, renal functiontest, Liver function test and Dengue IgM serology. Chest X
ray was taken todemonstrate pleural effusion. Children positive for IgM were followed
up for the clinicalprofile and outcome.
Results: Our study showed that the larger number of cases was in 6 to 12 years.).Males
were affected slightly more than females in total and also insubgroupsexceptin DHF
III.Itwas not significant (P>0.05).The mean duration of fever was 6.23 days.Pleural
effusion was seen 6 patients, of which more cases in dengue feverwith warning sign.
Abdominal tenderness was seen in 46% of cases, highest in denguefever with warning
signs and lowest in mild dengue which is statistically significant.Ascites was seen in 20
% of cases, highest in dengue fever with warning signs andDHF IV. Hepatomegaly was
seen in 30%, highest in DHF IV and lowest in mild dengue which is statistically
significant. The splenomegaly was seen in 4% of cases. AST was elevated in 36% of
cases. More in DHFIII & DHFIV cases, but it is not statistically significant. ALT was
increased in 30% of cases. More elevated cases are in DHFIII which was also not
significant.

FORMATION OF HERD IMMUNITY TO SARS-CoV-2 IN THE REGIONS OF UZBEKISTAN

Rakhimov R.A.; Ibadullaeva N.S.; Khikmatullaeva A.S.; Abdukadirova M.A.; Sadirova Sh. S.; Lokteva L.M.; Rakhimov R.R.; Bayjanov A.K.; Samatova I.R.

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 574-581

6 months after the start of the COVID-19 epidemic in Uzbekistan, a comparative analysis of the reported incidence of COVID-19 and the level of herd immunity to SARS-CoV-2 was carried out. The registration of patients with
COVID-19 in the country was carried out on the basis of the positive results of the examination for the presence of SARS-CoV-2 RNA, using the PCR method. To study herd immunity, the WanTai SARS-CoV-2 Ab Rapid test (China) was used to detect total antibodies (IgM and IgG) in blood. In the period from August 27, 2020 to September 11,   020, in all 14 administrative-territorial regions of Uzbekistan, blood samples of 86879 people who sought medical help at an outpatient clinic at their place of residence were tested for the presence of total antibodies to SARS-CoV-2. According to official figures, 0.14% of the population were infected with COVID-19. The proportion of the population with the presence of specific protective antibodies to the SARS-CoV-2 virus was 23.1%. This proves that the actual incidence of COVID-19, on the national average, was at least 165 times higher than officially reported. An uneven territorial distribution of the level of herd immunity was revealed. All regions were conditionally divided into 3 zones: 1) regions with a high level of herd immunity ˃ 20% (8 regions), 2) regions with an average level of herd immunity ˂ 20% and ˃ 10% (3 regions), 3) regions with a low the level of herd immunity ˂ 10% (3 regions). The degree of population affected in different regions of the county did not depend on the population density in the region, its age and gender composition. It was shown that the factors that influenced the intensity of the epidemic process and the formation of the level of herd immunity were the degree of external and internal migration.

FORMATION OF HERD IMMUNITY TO SARS-CoV-2 IN THE REGIONS OF UZBEKISTAN.

Rakhimov R.A.; Ibadullaeva N.S.; Khikmatullaeva A.S.; Abdukadirova M.A.; Sadirova Sh.S., Lokteva L.M.; Rakhimov R.R.; Bayjanov A.K.; Samatova I.R.

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1247-1252

6 months after the start of the COVID-19 epidemic in Uzbekistan, a comparative analysis of the reported incidence of COVID-19 and the level of herd immunity to SARS-CoV- 2 was carried out. The registration of patients with COVID-19 in the country was carried out on the basis of the positive results of the examination for the presence of SARS-CoV-2 RNA, using the PCR method. To study herd immunity, the WanTai SARS-CoV-2 Ab Rapid test (China) was used to detect total antibodies (IgM and IgG) in blood. In the period from August 27, 2020 to September 11, 2020, in all 14 administrative-territorial regions of Uzbekistan, blood samples of 86879 people who sought medical help at an outpatient clinic at their place of residence were tested for the presence of total antibodies to SARS-CoV-2. According to official figures, 0.14% of the population were infected with COVID-19. The proportion of the population with the presence of specific protective antibodies to the SARS-CoV-2 virus was 23.1%. This proves that the actual incidence of COVID-19, on the national average, was at least 165 times higher than officially reported. An uneven territorial distribution of the level of herd immunity was revealed. All regions were conditionally divided into 3 zones: 1) regions with a high level of herd immunity ˃ 20% (8 regions), 2) regions with an average level of herd immunity ˂ 20% and ˃ 10% (3 regions), 3) regions with a low the level of herd immunity ˂ 10% (3 regions). The degree of population affected in different regions of the county did not depend on the population density in the region, its age and gender composition. It was shown that the factors that influenced the intensity of the epidemic process and the formation of the level of herd immunity were the degree of external and internal migration.

FORMATION OF HERD IMMUNITY TO SARS-CoV-2 IN THE REGIONS OF UZBEKISTAN..

Rakhimov R.A.; Ibadullaeva N.S.; Khikmatullaeva A.S.; Abdukadirova M.A.; Sadirova Sh.S.; Lokteva L.M.; Rakhimov R.R.; Bayjanov A.K.; Samatova I.R.

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1529-1534

6 months after the start of the COVID-19 epidemic in Uzbekistan, a comparative analysis of the reported incidence of COVID-19 and the level of herd immunity to SARS-CoV-2 was carried out. The registration of patients with COVID-19 in the country was carried out on the basis of the positive results of the examination for the presence of SARS-CoV-2 RNA, using the PCR method. To study herd immunity, the WanTai SARS-CoV-2 Ab Rapid test (China) was used to detect total antibodies (IgM and IgG) in blood. In the period from August 27, 2020 to September 11, 2020, in all 14 administrative-territorial regions of Uzbekistan, blood samples of 86879 people who sought medical help at an outpatient clinic at their place of residence were tested for the presence of total antibodies to SARS-CoV-2. According to official figures, 0.14% of the population were infected with COVID-19. The proportion of the population with the presence of specific protective antibodies to the SARS-CoV-2 virus was 23.1%. This proves that the actual incidence of COVID-19, on the national average, was at least 165 times higher than officially reported. An uneven territorial distribution of the level of herd immunity was revealed. All regions were conditionally divided into 3 zones: 1) regions with a high level of herd immunity ˃ 20% (8 regions), 2) regions with an average level of herd immunity ˂ 20% and ˃ 10% (3 regions), 3) regions with a low the level of herd immunity ˂ 10% (3 regions). The degree of population affected in different regions of the county did not depend on the population density in the region, its age and gender composition. It was shown that the factors that influenced the intensity of the epidemic process and the formation of the level of herd immunity were the degree of external and internal migration.