Online ISSN: 2515-8260

Keywords : Acute Myeloblastic Leukemia (AML)

Coagulation and Fibrinolysis Profiles of Acute Myeloblastic Leukemia: Preliminary Assessment of Hypercoagulability

Edward Kurnia Setiawan Limijadi; Imam Budiwijono; Indranila Kustarini Samsuria; Purwanto Adhipireno; Wivina Riza Devi

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 607-615

Acute Myeloblastic Leukemia is an abnormality of haematological malignancy that often causes bleeding and death. Coagulation and fibrinolysis examinations are screening parameters that need to be reviewed related to the incidence of bleeding events in AML patients in a hypercoagulability assessment.This was a cross-sectional study conducted at Ulin Regional Hospital Banjarmasin on patients with a recent diagnosis of AML patients for the first time using a consecutive sampling method. The measurement of PT, aPTT, fibrinogen, and D-dimer levels were done at the Diponegoro National Hospital using Coalab-1000 tool. The analysis of the correlation between the
 ncidence of bleeding events with coagulation and fibrinolysis parameters used Fisher's exact test.The significance of the correlation test of the incidence of bleeding events with PT, aPTT, Fibrinogen, and D-dimer were 0.731; 0.086; 0.617; 0.587, and 0.731, respectively.The parameters of PT, aPTT, Fibrinogen and D-dimer were not associated with the incidence of bleeding events. The extension of PT and aPTT in most AML patients is suspected due to the deficiency of coagulation factors. Screening tests of PT, aPTT, fibrinogen and D-dimer levels should be performed in AML patients, although the results do not always show abnormalities