European Journal of Molecular & Clinical Medicine

Background:Acute coronary syndrome (ACS) can be divided into subgroups of ST-segment
elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction
(NSTEMI), and unstable angina. ACS carries significant morbidity and mortality and prompt
diagnosis.Thrombus encountered in the setting of acute coronary syndromes has been
correlated with acute complications during the percutaneous coronary intervention (PCI) such
as no-reflow, acute coronary occlusion, and long-term complicationsthat occurs later such as
stent thrombus.
Aim:To identify the electrocardiographic changes and the possible complications associated
with thrombus formation in patients with Non-ST Segment Elevation Myocardial Infarction
Methods:In this sample, 66 patients were enrolled in 2 groups; Group I (n = 33) represented the
low level of thrombus; Group II (n = 33) represented the high level of thrombus. The degree of
stenosis and coronary flux by thrombolysis in myocardial infarction (TIMI), grade, was
assessed in all patients to assess the associated high thrombus plaque disruption or formation.
Results:Class I and II have a mean age respectively 62.21±9.51 and a mean age of 66.67±9.14.
The global systolic average LV (AGS) in Group I and II relative to Group III was slightly lower.
Regarding the Killip class, the main difference between the groups was statistically
significantwith a P-value of 0.001, regarding ECG Changes (ST depression and t wave
inversion), the main difference between the groups was statistically non-significant with p
values 0.726 and 0.403 respectively.

Background: CHA2DS2VASc score is a predictive tool that enables estimation the risk of
developing ischemic stroke and thrombo-embolism in cardiac patient. Intracoronary thrombus
formation due to atherosclerotic plaque rupture and the interruption of coronary blood flow
constitute the main pathophysiology underlying acute coronary syndrome Objective:
Assessment of the ability of CHA2DS2-VASc score for predicting high intracoronary thrombus
and to evaluate the prognostic value of it in assessment of stroke, re-infarction and mortality in
patients with Non- ST-Elevation Myocardial Infarction (NSTEMI). Methods: Sixty-six patients
were enrolled in our study, divided into 2 groups; Group I (n = 33 patients) represents low
thrombus grade, Group II (n = 33 patients) represents high thrombus grade. All patients were
subjected to coronary angiography to assess degree of stenosis and coronary flow by
thrombolysis in myocardial infarction (TIMI) grade score. Sensitivity, specificity and diagnostic
accuracy of CHA2DS2-VASc in prediction of high thrombus burden were assessed. Results:
The mean age for Group I and II was 62.21±9.51 and 66.67±9.14 years respectively. LV
average global systolic strain (AGS) was significantly lower in group I and II when compared to
group III. Age, Killip class and LA diameters are highly significant predictors for incidence of
high CHA2DS2-VASc. The diagnostic accuracy of CHA2DS2-VASc in prediction of high
thrombus burden was 83.3% with cut-off value 4. Conclusion: CHA2DS2-VASc score is a good
predictor of intracoronary thrombus burden in non ST segment elevation myocardial infarction
patients undergoing primary PCI at a cutoff