Online ISSN: 2515-8260

Keywords : shock

A Hospital Based Prospective Study to Assess the Risk Factors Contributing to Increased Mortality in Children Admitted with Shock in PICU

Mamta Meena, Ramesh Chand Sharma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10502-10506

Background: Shock is one of the most dramatic, dynamic and life-threatening problems
faced by the physician in critical care setting.The mortality rate of shock in pediatric
patients has declined as a consequence of educational efforts (pediatric advance life
support), which emphasize early recognition and intervention and rapid transfer of
critically ill patients to a PICU via a transport service. To know about the risk factors in
a critically ill child with shock and its association with outcome, will give us an early
clue in identifying and prioritizing management strategies.
Material & Methods: A descriptive study done on 100 children in the age group of one
month to 12 years presenting with shock (or) who later develop shock during PICU stay
at RUHS College of Medical Sciences, Jaipur, Rajasthan, India during one year period.
Children who had received inpatient treatment prior to admission in PICU, post
cardiac arrest shock and traumatic shock / Burns were excluded in our study. During
the PICU stay periodic vital signs and other measures like urine output and oxygen
saturation were recorded. IV fluid therapy, rate and duration of inotrope and other
organ support like ventilatory support were documented.
Results: In present study the frequency of shock was found to be 1.64%.Undernutrition,
decompensated shock, cardiogenic shock, duration of shock more than 6 hours,
leucopenia, hypocalcemia, inotrope requirement, ventilator support & MODS was
present in higher proportion of children who died(36.11%, 69.44%, 27.77%, 72.22%,
22.22%, 38.88%, 94.44%, 97.23% & 69.45 respectively) when compared to those who
had survived (20.32%, 14.06%, 9.37%, 26.56%, 4.68%, 10.93%, 57.82%, 47.25% &
15.62% respectively). Oddsof different variables were measure among the children who
died, when compared tothose who had survived (2.17, 13.78, 3.56, 7.45, 5.89, 5.11, 13.87,
104.2 & 12.78 respectively.
Conclusion: We concluded that under nutrition, decompensated shock, inotrope
requirement, MODS, leucopenia and ventilatory support are independently associated
with poor outcome.

A Hypothetical Study on Immunogenic Expression of Novel Corona Vaccines.

Deepanwita Deka; Avra Pratim Chowdhury; Amrit Kumar

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 792-798

Boosted therapy of immunization against SARS-CoV2 has already been certified to
progress for humans all around the world. After having a long breakthrough of a
pandemic, the physiological response of human cells is now presenting as omnipotent
characters for their autoimmune criteria against a viral antigen, types, sub-types, strains,
and modified strains. The molecular genesis is migrated and conducts with a different
pattern of doses but specified in the same dosed to administer by injected protein
derivatives. The viral epitopes and their surface protein are concerned with the activation
of monoclonal antibodies by the artificial secondary immune response. The artificial
immunogenetic is explored by analytical research of several trials of virologists from mid-
August to December 2020.