Online ISSN: 2515-8260

Keywords : Herbal medicines


STUDIES on in VITRO ANTIOXIDANT ACTIVITY of VARIOUS EXTRACT of BUCHANIA LANZAN LEAVES

Bhushan Raghunath Pawar; Gurdeep Singh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 284-291

Background: Breast cancer is the most prevalent disease among women around the world, and is also the leading cause of death from cancer. Herbal medicine is an actual prehistoric form of healthcare known to mankind. Herbal medicine is being used by people belonging to all the cultures. The present study is based on the antioxidant and anti-cancerous potential of Buchanania lanzan which is also named as Chironji. Buchanania lanzan (chironji) is a tree species which belongs to the family Anacardiaceae and is commercially very useful. Methods: In vitro Antioxidant Activity 2, 2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging activity and reducing power assay Result: The total antioxidant activity of Buchanania lanzanin leaves was assessed based on scavenging activity of DPPH free radicals, among them pet ether extract of leaves shows 25.54 % inhibition at conc. of 20 μg / ml and at 100 μg / ml it shows 38.95 % inhibition. Ethyl acetate extract at 20 μg / ml it shows 38.41% inhibition and at 100 μg / ml it shows 50.36% inhibition. In methanolic extract at 20 μg / ml it shows 34.42% inhibition and at 100 μg / ml it shows 57.43% inhibition. The IC50 value is defined as the concentration of the substrate that causes 50 % loss of the DPPH activity. Reducing power assay of Petroleum ether extracts, ethyl acetate extract and methanolic extract of Buchanania lanzanwas studied at different concentrations and found to be increase with increase in concentration. Conclusion: Therefore, present study concludes that Buchanania lanzan is an excellent medicinal plant which holds numerous bioactive phytochemicals and it can be used in prevention of cancer

ANTIOXIDANT POTENTIAL of DIFFERENT SOLVENT EXTRACT ISOLATED from ALANGIUM SALVIFOLIUM

Avinash Shankar Bhosale; Gurdeep Singh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 292-299

Background: Medicinal plants are the “backbone” of traditional medicine, which means more than 3.3 billion people in the less developed countries utilize medicinal plants on a regular basis. Medicines derived from plants are widely famous due to their safety, easy availability and low cost. Herbal medicines may include whole parts of plant or mostly prepared from leaves, roots, bark, seed and flowers of plants. Present study established the antioxidant potential of Alangium salvifolium by studying the efficacy in preventing the in-vitro free radical using DPPH and reducing power assay. Methods: In vitro Antioxidant Activity 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and reducing power assay Result: Free radicals are highly reactive compounds that can produce oxidative stress on the body contributing to diseases such as atherosclerosis or cancer. The radical- scavenging activity of the pet ether extract, ethyl acetate extract and methanolic extracts of Alangium salvifolium was estimated by comparing the percentage inhibition of formation of DPPH radicals with that of ascorbic acid. The DPPH radical scavenging activity of pet ether extracts increased with increasing the concentration. The total antioxidant activity of Alangium salvifolium in flower was assessed based on scavenging activity of DPPH free radicals. Conclusion: Therefore, present study concludes that Alangium salvifolium is an excellent medicinal plant which holds numerous bioactive phytochemicals and it can be used in prevention of cancer.

CORRECTION OF METABOLIC PROCESSES UNDER EXPOSURE TO THE PESTICIDE PARARGYTE WITH THE ADDITION OF A PLANT PREPARATION COMPLEX

Aziza Nishanova; OishaAlaviya .; AdilovUtkir .; KhamrakulovaMukaddaskhon .; SadikovAskar .; ImanovFurkat .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2769-2784

Introductory information/relevance (Background): Widespread
prevalence of toxic hepatitis from chemical factors, the growth of chronic forms
of the disease, leading to a decrease in working capacity of the working
population, determine the multidimensionality of the problem and the relevance
of the development of new methods of prevention and treatment using a set of
herbal medicines.
Objective: Experimental study of the influence of the pesticide parargyte
on the functional state of hepatocytes and correction of metabolic processes with
the use of decoction from the complex of plant preparations.
Methods: Experimental studies were carried out on 146 white male rats
weighing 190-210. The mechanism of biological action of hepatotropic factors
was studied in acute and chronic experiments and correction of metabolic
processes with the addition of plant antioxidants.
Results (Findings): Experimental studies revealed that under the
influence of the pesticide propargit was observed a disturbance of carbohydrate
energy metabolism in the liver in all study periods. Application of a complex of
plant preparations to poisoned animals normalized the carbohydrate energy
metabolism and improved the functional state of the liver.
Conclusion: Application of the complex of herbal medicines - nettle
leaves, black currant fruits, rose hips, mountain ash fruits, green tea with
pesticide poisoning has a hepatoprotective effect on liver metabolism.