Keywords : Angiogenesis-Antiangiogenic Drugs-Diode laser-Sirolimus-Thalidomide-Skinfold window chamber
Thalidomide is better than Rapamycin in prevention of neovascularization after laser photocoagulation in dorsal window chamber rat model
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 3, Pages 863-878
Objectives: -This study examines the effect of two different antiangiogenic drugs (rapamycin
and thalidomide) in prevention of neovascularization when locally used, after laser
coagulation through dorsal skinfold window chamber rat model.
- Determine what is the most effective antiangiogenic drug when used locally and its
potential side effects.
The study includes 3 groups, each group contains 10 rats Thalidomide, Rapamycin and
control group (laser group). Blood vessels in the dorsal window chambers implanted on
dorsal skin of albino rats were irradiated by Diode laser pulses until coagulation occurs.
Blood flow and vessels structure were documented with high definition camera to evaluate
photocoagulation and reperfusion. Treatment groups received the treatment drug which
was injected to the widow’s medial side, every 3 days’ intervals for 2 weeks after laser