European Journal of Molecular & Clinical Medicine

Background: Breast cancer is the most prevalent disease among women around the world, and is also the leading cause of death from cancer. Herbal medicine is an actual prehistoric form of healthcare known to mankind. Herbal medicine is being used by people belonging to all the cultures. The present study is based on the antioxidant and anti-cancerous potential of Buchanania lanzan which is also named as Chironji. Buchanania lanzan (chironji) is a tree species which belongs to the family Anacardiaceae and is commercially very useful. Methods: In vitro Antioxidant Activity 2, 2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging activity and reducing power assay Result: The total antioxidant activity of Buchanania lanzanin leaves was assessed based on scavenging activity of DPPH free radicals, among them pet ether extract of leaves shows 25.54 % inhibition at conc. of 20 μg / ml and at 100 μg / ml it shows 38.95 % inhibition. Ethyl acetate extract at 20 μg / ml it shows 38.41% inhibition and at 100 μg / ml it shows 50.36% inhibition. In methanolic extract at 20 μg / ml it shows 34.42% inhibition and at 100 μg / ml it shows 57.43% inhibition. The IC50 value is defined as the concentration of the substrate that causes 50 % loss of the DPPH activity. Reducing power assay of Petroleum ether extracts, ethyl acetate extract and methanolic extract of Buchanania lanzanwas studied at different concentrations and found to be increase with increase in concentration. Conclusion: Therefore, present study concludes that Buchanania lanzan is an excellent medicinal plant which holds numerous bioactive phytochemicals and it can be used in prevention of cancer

Background: Medicinal plants are the “backbone” of traditional medicine, which means more than 3.3 billion people in the less developed countries utilize medicinal plants on a regular basis. Medicines derived from plants are widely famous due to their safety, easy availability and low cost. Herbal medicines may include whole parts of plant or mostly prepared from leaves, roots, bark, seed and flowers of plants. Present study established the antioxidant potential of Alangium salvifolium by studying the efficacy in preventing the in-vitro free radical using DPPH and reducing power assay. Methods: In vitro Antioxidant Activity 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and reducing power assay Result: Free radicals are highly reactive compounds that can produce oxidative stress on the body contributing to diseases such as atherosclerosis or cancer. The radical- scavenging activity of the pet ether extract, ethyl acetate extract and methanolic extracts of Alangium salvifolium was estimated by comparing the percentage inhibition of formation of DPPH radicals with that of ascorbic acid. The DPPH radical scavenging activity of pet ether extracts increased with increasing the concentration. The total antioxidant activity of Alangium salvifolium in flower was assessed based on scavenging activity of DPPH free radicals. Conclusion: Therefore, present study concludes that Alangium salvifolium is an excellent medicinal plant which holds numerous bioactive phytochemicals and it can be used in prevention of cancer.