Online ISSN: 2515-8260

Keywords : clinical profile


A study on clinical profile of cases with organ phosphorus poisoning at a tertiary care hospital

Dr. Nagaraj M Bhat B, Dr.Sharanappa G Pattanshetty, Dr. Divya Chandra, Dr. Manoj Chandra M.C

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11921-11925

In India OPC intake is the commonest method of suicide (40.5%) after hanging (49%).Hospital-based data suggest that barbiturates and copper sulfate were the commonly used agents for suicide in the years, 1972-1977; however, later they were replaced by OP compounds and aluminium phosphide. Organo phosphorus insecticides are responsible for as much as 75% of all poisonings in our country today. Observation method of primary source of information in the department of general medicine at. Secondary source of information from published articles, journals, books, case sheets, discharge summary, related websites are used in planning, developing, synopsis and during dissertation as supporting document. In our study, subjects predominantly had GI symptoms. 56% had pain abdomen, 42% had vomiting, 24% had Diarrhea, 26% had Sweating, 21% had Fasciculation and 15% had Bradycardia.

The Clinical Profile of Anaemiaand Factors Associated with Anaemia Among Adolescent (13-19 Yrs) Girls

Guruprasad Hosamani, Rashmi M. B, Rashmi Ullagaddi, Sushrit A. Neelopant

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 353-361

Background: The worldwide prevalence of anaemia among adolescents is high and even
higher in developing countries. The burden of anaemia is a major contributor for low
birth weight, lowered resistance to infection, poor cognitive and motor development,
weakness, fatigue, difficulty in concentrating and lower productivity. India had
reported high prevalence of anaemia among adolescent girls, which is apparently higher
when compared with the other developing nations. Objectives: To study the clinical
profile of anaemia among Adolescent (13-19 years) girl students and to determine the
factors associated with anaemia in Adolescent girl students like socio – demographic
factors, prevalence of anaemia and clinical profile.
Materials and Methods: Single centre, cross sectional study, sociodemographic and
clinical details were collected and analyzed. Blood test was done to estimate anaemia
and to classify type of anaemia. Prevalence of anaemia was compared with
sociodemographic and other details to look for association.
Results: The prevalence of anaemia in the present study was 25%, 78 (39%) girls
belonged to class IV. Students not wearing footwear, not washing hand, not consuming
jaggery, history of recurrent infections, passing worms, irregular cycle were anemic.
Majority of cases had microcytic hypochromic anaemia.
Conclusion: 25% prevalence is noted in our study which is of moderate magnitude.
Most commonly microcytic hypochromic anaemia 60% was noted followed by
normocytic normochromic 30%. High risk factors were students belonging to low socio
– economic groups, with Low BMI, not using foot wear, and present of menstrual
abnormalities like polymenorrhoea.

Clinical profile, electrophysiological findings, treatment response of Guillain Barre Syndrome: A retrospective study from tertiary care centre in Central India

Dr Rohit Prabhash, Dr Dinesh Chouksey, Dr Rishu Garg

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 4867-4878

Introduction: Guillain–Barre Syndrome (GBS) is an acute, immune-mediated
polyradiculoneuropathy with a diverse clinical course and outcome and is the most
common cause of acute flaccid paralysis in the adult population.
Aim: To study the clinical profile, treatment response of GBS patients and to see their
association with electrophysiological subtypes of GBS.
Materials and Methods: We conducted a retrospective study of patients with Guillain-
Barre syndrome, presented at Sri Aurobindo Medical College and PG Institute, a
tertiary care centre in Madhya Pradesh, Central India, from January 2013 to January
2020. All patients diagnosed with Guillain-Barre syndrome were included in this study.
The handwritten case record files of the study population were retrieved from medical
record section of the institute.
Results: There were 70 patients with a male to female ratio of 1.4:1 and 70 % of them
were < 40 years of age. Antecedal infections were the preceding events in 31/70(44.3%).
Cranial nerve involvement was found in 25/70(17.5 %), 36/70(25.2%) patients had
dysautonomia and 17 (24.3%) cases requiring ventillatory support. The commonest
sub-type was acute inflammatory polyradiculoneuropathy 40(57.1%). Fever was seen in
more numbers of AIDP patients and preceeding GI symptoms were more seen in
AMAN and AMSAN variants . Autonomic dysfunction and need of ventillatory support
were more in axonal variants of GBS patients. High EGRIS score and long duration of
hospital stay were seen in axonal variant of GBS. Shorter duration of illness, rapidly
progressive motor weakness of the limbs, longer duration of hospital stay, cranial nerve
involvement, bladder dysfunction ,autonomic involvement, low MRC score(≤ 30), high
EGRIS score(> 4),high HDS score on admission were prone for ventillatory support.
Age >40 years, non treatment with immunomodulators, higher mEGOS on admission
were associated with poor outcome on discharge.
Conclusion: Early recognition of these risk factors helps in more vigilant management
of patients associated with high morbidity who are eligible for additional treatment in
future. AIDP variant is more common in our region and poor prognosis and long
hospital stay for AMAN and AMSAN variants of GBS.

Clinical profile of children with supracondylar fractures of humerus admitted to tertiary care hospital

Dr. Sunil Kumar TR, Dr. Harish YS, Dr. Vivekananda BR, Dr. Srinath Sallur Anand, Dr. Nachiketan K Dore

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1833-1838

Although the incidence of these fractures generally has been reported to be higher in boys, more recent reports indicate that the frequencies of supracondylar humeral fractures in girls and boys seem to be equalizing, and some series actually have reported higher rates in girls. As soon as the patient was admitted, a detailed history was taken and a meticulous Examination of the patient was done. The required information was recorded in the proforma prepared. The patients radiograph was taken in antero-posterior and lateral views. The diagnosis was established by clinical and radiological examination. Out of 30 extension type, 15 patients had posteriomedial displacement while 10 patients had posteriolateral displacement. 5 patient were of Type II Gartland classification with posterior displacement. We encountered loss of pulse in one patient which recovered as soon as fracture was reduced. Median and radial Nerve injury in one patient each was encountered out of 30 patients which spontaneously recovered by 4-6 weeks’ time.

A study on clinical profile of patients with the diabetic complications: descriptive study

Dr. Parashuram, Dr. Pratibha Vasu, Dr. Chandana R Gowda

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1972-1976

Type 2 diabetes, is caused by insulin resistance which is characterized by a decreased effectiveness of insulin. In contrast to type 1 diabetes in which the pancreatic islets are destroyed and no insulin can be synthesized anymore, in type 2 diabetes insulin secretion is normal, elevated or reduced. Unlike in patients with type 1 diabetes, symptoms do not appear abruptly, but set on gradually so that the disease often remains undiagnosed for a long time. The present study included 150 patients of type 2 diabetes mellitus. Patients with Type 2 Diabetes mellitus in outpatient and inpatient departments were study subjects. The present study had diabetic patients ranging from 41 to 80 years of age. Majority of cases were in the 61 to 70 age group. Male cases were 58.7% and female cases were 41.3%. 60% of cases of Type 2 DM were associated with complications of which 66.7% were microvascular and 33.3% were macrovascular complications.

Clinical profile of patients with liver abscesses admitted to a tertiary care hospital

Dr. Ajith MB, Dr. Niyaz Ahmed, Dr. Shrinidhi B Joshi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2086-2090

In Asian populations, Kiebsiella pneumoniae is the most frequent pathogen associated with cryptogenic PLA‘s. Diabetes mellitus is suggested to be an important risk factor, but the pathogenesis is still unclear. E. coli is the most common pathogen in Western countries, in both monomicrobial and polymicrobial isolates, followed by Streptococcus milleri. Anaerobes may also be cultured from PLA‘s and Bacteroides spp. are the most common isolated organism. After obtaining approval and clearance from the institutional ethics committee, the patients fulfilling the inclusion criteria will be enrolled for the study after obtaining informed consent. Case record form with follow up chart. All cases had undergone thorough history and detailed clinical examination at the time of admission. Total and differential leukocyte counts was measured with an auto-analyzer. In this study it is found that liver abscess presents with most common presentation as pain abdomen and fever. In this study it is found that fever, loose stools are presenting features of liver abscess in most of the individuals along with pain abdomen.

Clinical profile of patients of chronic kidney disease undergoing regular twice weekly maintenance hemodialysis

Dr.Raghu Nandan,Dr.Anil Kumar,Dr.Vinay Durgad

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 295-300

With increasing life expectancy and prevalence of life style diseases, United States (US) has
seen a 30% increase in prevalence of chronic kidney disease (CKD) in the last decade.
Unfortunately, from India there is no longitudinal study and limited data on the prevalence of
CKD. Chronic Kidney Disease was diagnosed when at least one of the evidence of chronicity
like documented renal failure for >3 months, bilateral small kidneys, histological evidence of
chronicity or GFR < 30 ml/min for 3 or more months was present.A pre informed written
consent was obtained from every case before inclusion in the study. The clinical and
demographic profile was recorded in a specially designed proforma. On ultrasonogram
bilateral kidneys of group A, 12 patients had bilateral contracted kidneys which correspond to
60% of the study patients indicative of ESRD. 6 patients had normal or slightly enlarged
kidney size suggestive of diabetic nephropathy (30%). Findings of ultrasonogram bilateral
kidneys in group B revealed 11 patients had bilateral contracted kidneys which correspond to
55% of the study participants indicative of ESRD. 5 patients had normal or slightly enlarged
kidney size (25%) and 1 patient was having bilateral enlarged kidneys with multiple cysts of
varying sizes suggestive of autosomal dominant polycystic kidney disease (5%).

To study the Presentation, etiology and Viral markers in children with Hepatitis ata tertiary Care hospital

Khurrum Hayat, Rehana Barkat

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 742-746

Aim: The aim of this study to determine the Presentation, etiology and viral markers in
children presenting with hepatitis at a Tertiary care hospital.
Methods: 50 cases of acute hepatitis of age 1-13yrs were included in the study. Acute
hepatitis was diagnosed on the basis of history, clinical (Jaundice, pain in upper
abdomen, anorexia, nausea, vomiting, fever, pruritis, tender/non tender hepatomegaly
with or without ascites and without any stigmata of chronic liver disease) and
biochemical evaluation (LFT i.e. serum bilirubin, Alanine
aminotransferase(ALT),Aspartate aminotransferase (AST),alkaline phosphatase(ALK),
serum albumin, PT/INR). Acute liver failure was diagnosed by PT>15sec/ INR>1.5 with
features of encephalopathy or PT > 20 sec/ INR > 2 regardless of presence of clinical
hepatic encephalopathy.. Patients were also tested for viral markers i.e. anti HAV IgM,
anti HEV IgM, HBsAg, and anti HCV.
Results: In our study total number of cases were 50 of which 70% were male and 30%
were female. The most common cause of viral hepatitis was hepatitis A (80%). Hepatitis
B was found in 2 (4%) cases and in 16% cases no viral marker was detected. The most
common clinical presentations were jaundice (96%), fever (94%), fatigue (90%) and
nausea/vomiting (78%). In 80% of cases hepatomegaly was found and splenomegaly
was seen in 2% of cases. SGPT level was increased in all cases with 30% in the range
500 – 1000 units/ml, 22% in the range of 1000 – 3000 units/ml and 12% in the range of
3000 – 5000 range. 48% of cases has total bilirubin of more than 10mg/dl and in 40% of
cases the value was in the range of 5 – 10 mg/dl. In 35cases PT was < 15sec and in 15
cases it was more than 15 sec. The disease resolved in 40(80%) cases,1(2%)had chronic
disease and 9(18%) cases expired.
Conclusions: Majority of cases in children were hepatitis A cases. Most of the cases
were Boys. Those cases with INR >3 at admission has higher mortality. Peak values of
aminotransferase i.e. ALT and AST though reflect hepatocyte damage do not correlate
with mortality.

A Study on clinical profile of severe dengue fever in children

Dr.Sudhakar Hegade, Dr.Karthikeyan, Dr.Prabhakar B Hegade

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1227-1231

Dengue virus, a mosquito-borne flavivirus, is the causative agent, currently one of the most
significant emerging disease challenges to global health. The dengue virus are single-stranded
positive-sense RNA viruses with a genome of about 11000 bases that codes for three
structural proteins, C(core protein), M (membrane protein), E (envelope protein); 7
nonstructural proteins, NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5; and short non-coding
regions on the 5' and 3' ends. This was a case control study design in which 201 cases of
dengue fever admitted in the pediatric emergency ward, were enrolled. After taking written
informed consent, data were collected in a predesigned semi structured questionnaire
regarding Socio-Demographic profile, medical history, clinical and hematological profile and
outcome. 8(4%) of cases had positive family h/o dengue fever, 3(1.5%) cases had positive
past h/o dengue fever and 8(4%) cases had positive h/o travel to dengue endemic areas.
201(100%) cases had fever, 94(46.8%) had persistent vomiting,91(45.3%) had
anorexia,78(38.8%) had abdominal pain, 59(29.4%) had headache, 30(14.9%) had rashes, 16
(8%) had facial puffiness, 14(7%) had convulsions and 12(6%) had abdominal distension.

CLINICAL PROFILE OF PATIENTS WITH TRAUMATIC THORACOLUMBAR SPINE FRACTURE ADMITTED AT A TERTIARY CARE HOSPITAL

Dr. MukeshDhruw, Dr. Pravesh Mishra, Dr. ProsenjitHaldar

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1584-1587

Spinal cord fills about 50% of the canal in the thoracolumbar segments. The remainder of the canal is filled with Cerebrospinal fluid, epidural fat and meninges. The spatial relationships of grey and white matter structures remain consistent throughout the length of the cord, but the proportions change based on the level. All the patients had routine X-rays of thoracolumbarspine in both Anteroposterior and Lateral views.In all the patients MRI spine and 3D CT ofspine with 2mm thick film uploaded in navigation machine which gives 3D image of the vertebrae. After registration in navigation machine, the pedicle screw trajectory, size and length planned and placed in the center of the pedicle.In our study we had 69.23% males and 30.77% female patients in conventional method and had 84.61% males and 15.39% female patients in navigation method. The average age was 36 years and 29 year in conventional method and navigation method respectively, with male predominance in each group.

Assessment of the risk factors and clinical profile of CAD in female patients

PranavAshokrao shende; S. K. Malani; Ravindra K. Jain; Chandrakant S. Upadhayay; Snehal A Shende; Vivek V. Manade

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 7130-7136

Background:Coronary artery disease (CAD) has emerged as the major cardiovascular disease of the era and also the commonest cause of premature death. For several decades, conventional invasive angiography (CIA) has been considered as the well-established gold standard for making the diagnosis of CAD. Hence; the present study was undertaken with the aim of assessing the risk factors and clinical profile of CAD in female patients. Materials & methods:A hospital-based descriptive observational study was conducted with 100 patients to evaluate clinical profile and angiographic pattern in women with Coronary Artery Disease. Baseline demographics, clinical and risk factor profile was collected. Disease is defined as presence of stable angina, unstable angina or myocardial infarction. Baseline demographics, clinical and risk factor profile was collected. Appropriate statistical software, including but not restricted to MS-Excel. SPSS version 20 was used for statistical analysis. Graphical representation was done in MS-Excel 2010.