Online ISSN: 2515-8260

Keywords : Procalcitonin


Prognostic significance ofProcalcitonin, High sensitivity C-reactive proteinandwhite blood cell count incomparison withblood culture in ICU patients with Sepsis and Septic shock inatertiary care Hospital

Dr.Kondle Raghu; Dr. Krishnan Ramalingam

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2263-2270

Background: Sepsis is a life-threatening condition in ICU with high morbidity and
mortality. Biomarkers which can act as a predictor for diagnosis, prognosis, and patient
outcome in sepsis are needed.
Aim:Aim of the study is to compare the significance of hs-C-reactive Protein (CRP),
Procalcitonin, White blood cell count, and blood culture in patients with bloodstream
infections and compare their prognostic significance with blood cultures in sepsis.
Materials and Methods: This hospital based prospective observational study was conducted
between July 2018 to July 2019 forone year with 216 cases of sepsis. Serial determination
of Procalcitonin and CRP at admission and Day 6 was done. Data was analyzed check to
compare the prognostic significance of the PCT, CRP, and WBC count.
Results:A blood culture positivity rate of 50.9% was reported with male preponderance.
WBC count has significantly reduced after 72hrs of admission (p= 0.007). CRP levels have
significantly reduced on day 6 (p = 0.043) in comparison to at the time of admission (p=
0.032). The serial determination of PCT levels at admission and on day 6 (p= 0.032) was
found to be a better prognostic indicator in patients with sepsis than at the time of
admission. The significant patient outcome in terms of mortality and reduction in length of
hospital stay has been found (p= 0.018, p=0.002). The positive correlation of PCT and CRP
and SOFA score has been reported.
Conclusion: Prognostic significance was found for the biomarkers PCT, CRP, and WBC
count with significant patient outcomes in terms of mortality and hospital stay reduction

Evaluation of procalcitonin level in saliva and in periimplant crevicular fluid in peri- implantitis, peri- mucositis and in healthy subjects

Dr. Anjaneya Mahapatra; Dr. Ankita Priya; Dr. Surabhi Duggal; Dr. Vishvnathe Udayshankar; Dr. Sharmila Kumari; Dr. M Bhavani

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 7174-7178

Background:The present study evaluated level of PCT in saliva as well as in PICF in peri -
implantitis along with healthy subjects.
Materials & Methods: 25 patients of peri-implant mucositis (group I), 25 of peri- implantitis
(group II) and 25 healthy controls (group III) were assessed for peri -implant plaque index,
probing depth, and bleeding on probing at four sites per implant was performed. The
measurement of PCT in saliva and peri- implant crevicular fluid was performed.
Results: The mean salivary flow rate was 0.61 ml/ minute in group I, 0.64 ml/ minute in
group II and 0.63 ml/ minute in group III. The mean salivary procalcitonin level was 3.12
pg/mL in group I, 18.4 pg/mL in group II and 48.5 pg/mL in group III. The mean PICF flow
rate was 0.75 μl/minute in group I, 0.93 μl/minute in group II and 1.05 μl/minute in group III.
The mean PICF procalcitonin level was 7.28 pg/mL in group I, 41.3 pg/mL in group II
and 118.6 pg/mL in group III.
Conclusion: Higher level of salivary and peri- implant crevicular fluid level of procalcitonin
in peri- implantitis and peri- mucositis patients as compared to healthy subjects.