Online ISSN: 2515-8260

Keywords : Iron deficiency


HEREDITARY HAEMORRHAGIC TELANGIECTASIA

Dr Arpita Krishna ,Dr Gopika Balachandran, Dr Manu S Babu, Dr Mayur Ingale, Dr Yash Jain

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 7333-7337

Hereditary hemorrhagic telangiectasia or Osler Weber Rendu syndrome is an autosomal dominant vascular disorder that affects multiple systems. It is characterised by skin and mucosal telangiectasias and arteriovenous malformations.
Hereditary  hemorrhagic telangiectasia is a disease more commonly associated with significant morbidity than mortality.It is a rare genetic disorder known for its debilitating symptoms.More than 90% of patients with HHT experience epistaxis,which may cause anaemia if uncontrolled(1,2) and they average upto 18 bleeds per month. Patients also present with arteriovenous malformations in various organs and suffer from many complications including bleeding ,anemia,iron-deficiency, and high output high failure. Families with the same mutation exhibit considerable phenotypic variation
In this case report we present  a 67 year old male with epistaxis on and off since 20 years ,aggravated since last few days around 300-400 ml  along with generalised weakness who came with family  history of similar complaints in 13 members of the family managed with bilateral electrocauterisation of nasal cavities with post op sesame oil application and tab tranexemic acid 250mg OD.Patient is on regular follow up.
Optimal treatment is best delivered a multidisciplinary approach with appropriate diagnosis , screening and local and/or systemic management of lesions.Anti-angiogenic agents such as bevacizumab have emerged as a promising systemic therapy in reducing bleeding complications but are not curative. Other pharmacological agents include iron supplementation, antifibrinolytics and hormone treatment

Estimation of Serum Iron Level in Undernourished Children in Rhohilkhand Region U.P Bareilly

Nilima Kumari; Pratima Verma; Vibha Tandon; Manish Goyal .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 8769-8773

Background: The overall objective is to “Assess the serum iron level in moderate & severe undernourished children (1-5 years)” in Rohilkhand Medical College & Hospital, Bareilly.
Materials and Methods: The nutritional status of the children was assessed by plotting the weight and height of the children on WHO 2006 Growth Standards growth charts. Weight for age and height for age assessment was done by plotting the study subject’s weight and height on different growth charts for boys and girls. Nutritional status as per BMI for age criteria was also assessed by plotting the study subject’s BMI for their respective age.
Results: Out of 202, 103 children were undernourished children and 99 children were healthy children which were control. Total cases were 51%, among cases 22.8% were severe malnourished children and 28.2%Serum Iron level of control were 139.31±20.19 ug/dL and moderate and severe malnourished children were 99.49± 10.05 and 75.71± 10.92 ug/dL respectively. Serum iron level of malnourished cases was significantly low having p value less than 0.001.
Conclusion: Serum iron profile can be used as a prognostic marker in PEM patients. Routine measurement of serum iron and its subsequent supplementation in PEM children could improve the management of this group of patients.

Analysis of Hematological Abnormalities associated with Rheumatoid Arthritis Patients at a Tertiary Care Centre

Manish Mittal; Deepak Verma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 5, Pages 489-493

Introduction: Rheumatoid arthritis (RA) is a systemic inflammatory disorder associated with significant proportion of haematological abnormalities. The present study was undertaken for assessing the haematological abnormalities among rheumatoid arthritis patients. The main aim of the study is to study the prevalence of haematological manifestations in patients with seropositive rheumatoid arthritis.

Serum Iron Profile in Non-Dialysis Chronic Kidney Disease Patients with Anemia

Sawjib Borphukan, Mohit Goyal, Girindra Nath Gogoi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1293-1302

Background: The present study aimed to evaluate the levels of serum iron, total iron
binding capacity (TIBC), transferrin saturation and serum ferritin in diagnosed cases of
chronic kidney disease due to any aetiology not undergoing dialysis. Study also aimed to
determine the correlation between serum creatinine and serum iron levels in chronic
kidney disease in this group of patients.
Materials and Methods: The present study was conducted in the city of Dibrugarh and
which also included patients belonging to adjoining districts of Upper Assam from 20th
October 2018 to 19th October 2019 for a period of 1 year. A clinico-hematological study
was undertaken to evaluate the levels of serum iron, total iron binding capacity (TIBC),
transferrin saturation and serum ferritin in diagnosed cases of chronic kidney disease
(not on dialysis) due to any aetiology. Study included 110 old and newly diagnosed cases
of CKD attending the out–patient department not on dialysis. A cut-off off Hemoglobin
<13 g/dl in men and <12 g/dl in women was used to make the diagnosis of anemia.
Results: Prevalence of anemia among CKD cases was observed as 74.6% with Hb level
<6 gm% was observed in 6.4% cases. Normocytic normochromic picture was observed
in 53.6% cases. Decreased level of serum iron, ferritin, TIBC and transferrin saturation
was seen in 99.1%, 16.4%, 52.75 and 78.2% cases respectively. Mean levels of
haemoglobin, RBC and iron indices (except for TIBC levels) decreased significantly
with increase in the CKD stage. A significant positive correlation was observed between
eGFR levels with haemoglobin and iron indices (except TIBC) while an inverse
correlation was observed with creatinine levels.
Conclusion: Anemia among Pre dialysis-CKD cases is mostly normocytic and moderate
in severity. Functional iron deficiency was the predominant form of iron deficiency in
these patients. Both hemoglobin and other iron indices worsens with progressive loss of
kidney functions.

The Relationship between Iron Deficiency Anemia and Simple Febrile Convulsion in Children Aged 6 Months to 5 years

Mohammad Hadi Yarigarravesh; Shadi Izadbakhsh; Parastoo Amiri; Maryam Goudarzian; Mehdi Jalili Akbariyan; Kazem Hassanpour

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1049-1057

This study aimed to evaluate the relationship between simple febrile convulsion and iron deficiency anemia in children. In this case-control study, 60 children aged 6 months to 5 years old with simple febrile convulsion hospitalized in the Pediatric Unit of Heshmatiyeh Hospital of Sabzevar. separately for case and control groups and the two groups were compared in terms of blood indexes and iron deficiency anemia. The significance level was considered Pvalue <0.05. The case and control groups were matched in terms of age and sex, and there was no significant difference between the two groups. The results showed the prevalence of iron deficiency anemia in the febrile convulsion group was somewhat lower than that of the control group. However, no significant difference was found between the two groups (p> 0.05). The results of this study showed that the risk of convulsion is not higher in cases with anemia. However, iron can be prescribed with caution for high-risk patients with a history of previous convulsion or a positive family history of this condition, if they suffer from iron deficiency anemia. Moreover, according to the results of previous studies and the present study, conducting extensive research simultaneously in several centers is recommended.