Online ISSN: 2515-8260

Keywords : Diabetes mellitus


Evaluation of Anti-Hyperglycemic Effect of Passiflora Edulis Sims (Yellow Passion Fruit) Juice on Alloxan Monohydrate Induced Diabetes Mellitus in Male Sprague Dawley Rats

Merlita C. Medallon; Leah Quinto; Allysa Mae P. Nipolo; Eric M. Pujante; Jessa Marie P. Sebolino; Jay Steven G. Toreja

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4107-4113

Nowadays, the incidence of Diabetes Mellitus (DM) is growing around the world. In fact, it is one of the most serious diseases among adults in the age of 45 and a life - threatening disease over the age of 50, resulting to be the leading causes of death in which Filipinos are also affected by the disease. One of the most known way to treat DM is using insulin. However, side effect, toxicity, and organ damage may happen due to continuous usage of synthetic anti-hyperglycemic agent. Therefore, finding non-toxic and affordable treatment for Diabetes such as medicinal plants is presented. Present investigation was undertaken to investigate the ability of Passiflora edulis sims (yellow passion fruit) pulp juice as anti-hyperglycemic agent on male Sprague-dawley rats, and to compare and evaluate which concentration used in the study of Passiflora edulis sims pulp juice is significantly better as anti-hyperglycemic agent. Thirty (30) individual rats were used in this experiment, 10 of them are used for toxicity testing and no toxic effect has been observed after 24 hours. The remaining 20 rats were randomly divided into five (5) groups, DM was induced by using Alloxan monohydrate dissolved in 0.5 M buffered citrate at a pH of 4.5 and was injected intraperitoneally. Treatment was done by oral administration of yellow passion fruit pulp juice, 1ml, 1.5ml, 2ml, and 2.5ml respectively. The effectiveness of fruit juice was compared with a control group this include diabetic rats treated with water. Results of the study revealed that 1.5 mL, 2mL and 2.5mL concentration of the fruit juice significantly decrease the blood glucose of the diabetic rats while pre and post blood glucose only shows a significant decrease on group 4 and group 5, the highly evidence of anti-hyperglycemic factor occur. Therefore, the Passiflora edulis sims pulp juice fruit juice can be used as alternative treatment for diabetes mellitus

Effect of Diabetes Mellitus Patient Adherence in Following Prolanis Activities on HbA1C Profile at UPTD Puskesmas Nursing Ngletih Kediri

FidiSetyawan .; Hanik Mariana Dewi; Sri Rahayu D.P; ArifWijayanto .; Nur Wijayanti; Hanie Kusuma Wardani

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 5, Pages 935-941

Diabetes Mellitus (DM) is a chronic disease that has become a major health problem in Indonesia. The Chronic Disease Management Program (Prolanis) developed by BPJS Kesehatan in collaboration with First Level Health Facilities (FKTP) seeks to promote and prevent DM disease control. Efforts made include controlling the glycemic index to prevent microvascular and macrovascular complications that may occur with activities including medical consultation, counseling, home visits, club activities, and monitoring of health status. Aim : The purpose of this study was to analyze the effect of DM patient adherence in participating in Prolanis activities on the patient's HBA1C profile. Method:This study is an analytical study using a retrospective cohort design. The research data is secondary data obtained from the Medical Records of DM patients from January-April 2019. The research subjects were 42 DM patients who were registered as active Prolanis participants who had HBA1C data at the April 2019 examination. Result: The results of this study showed that the mean HBA1C value in 22 patients who routinely followed prolanis activities (7.2 ± 1.48)% was more controlled than the mean HBA1C in 20 patients who did not routinely participate in prolanic activities (9.27 ± 2.06)% . Conclusion: From this study it can be concluded that there is a significant difference between DM patients who adhere to the schedule of prolanis activities and patients who do not comply with the schedule of prolanist activities at the UPTD Puskesmas Nursing Ngletih Kediri City with a value of p = 0.001 (p <0.05; CI = 95% )

The Potential Of Durian Seed Flour As An Alternative Source Of Carbohydrate For Diabetes Mellitus Sufferers

Purnama Ningsih; Irwan Said; Baharuddin Hamzah; I Made Tangkas; Izlah K. Bissin

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 727-734

Abstract— Durian seed flour is a source of carbohydrates that has the potential to be used to meet the carbohydrate needs of Type 2 Diabetes Mellitus (DMT-2) sufferers, but before it is used to fulfill carbohydrate needs in diabetes sufferers, an in vivo test is needed to identify the glycemic index (GI) of the flour. This study aims to determine the glycemic index of durian seed flour given orally to Sprague Dawley rats. This research was arranged in 2 steps, namely the manufacture of durian seeds flour and the glycemic index test with 5 repetitions with time variations 0; 30; 60; and 120 minutes at 3 days intervals using a glucometer. Rats were grouped into 3 groups each consisting of 2 rats. Flour was suspended in 0.1% sodium carboxymethyl cellulose (Na-CMC) at a dose of 0.5625 g, positive control was 1.125 g of glucose that given in an oral way. Data in the form of test animal blood glucose levels versus time were analyzed into the Area Under Curve (AUC) glucose levels versus AUC. GI calculations were carried out by comparing AUC of durian seed flour to glucose AUC. The results of the research and calculations carried out obtained the GI of durian seed flour of 10.90 with low criteria category. With this GI value, it can be stated that durian seed flour has the potential as a source of carbohydrates for DMT-2 sufferers.

Effect Of Diabetes Mellitus Patient Adherence In Following Prolanis Activities On Hba1c Profile At UPTD Puskesmas Nursing Ngletih Kediri

Fidi Setyawan; Hanik Mariana Dewi; Sri Rahayu D.P; Arif Wijayanto; Nur Wijayanti; Hanie Kusuma Wardani

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4624-4639

Diabetes Mellitus (DM) is a chronic disease that has become a major health problem in Indonesia. The Chronic Disease Management Program (Prolanis) developed by BPJS Kesehatan in collaboration with First Level Health Facilities (FKTP) seeks to promote and prevent DM disease control. Efforts made include controlling the glycemic index to prevent microvascular and macrovascular complications that may occur with activities including medical consultation, counseling, home visits, club activities, and monitoring of health status.
Aim : The purpose of this study was to analyze the effect of DM patient adherence in participating in Prolanis activities on the patient's HBA1C profile.
Method:This study is an analytical study using a retrospective cohort design. The research data is secondary data obtained from the Medical Records of DM patients from January-April 2019. The research subjects were 42 DM patients who were registered as active Prolanis participants who had HBA1C data at the April 2019 examination.
Result: The results of this study showed that the mean HBA1C value in 22 patients who routinely followed prolanis activities (7.2 ± 1.48)% was more controlled than the mean HBA1C in 20 patients who did not routinely participate in prolanic activities (9.27 ± 2.06)% .
Conclusion: From this study it can be concluded that there is a significant difference between DM patients who adhere to the schedule of prolanis activities and patients who do not comply with the schedule of prolanist activities at the UPTD Puskesmas Nursing Ngletih Kediri City with a value of p = 0.001 (p <0.05; CI = 95% )

Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder

Oleg V. Ermilov; Andrey Yu. Tretyakov; Lyubov V. Romasenko; Nina I. Zhernakova; Elizaveta S. Rudycheva; Inna V. Tikhonova; Irina A. Misan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 122-127

Objective: To describe the features and mechanisms of development of metabolic
syndrome (MS), type 2 diabetes melitus (DM2) and intermediate states of glycemia in
psychosis the occurrence of these disorders, the values of total cholesterol (TC),
fractions of high density lipoproteins (HDL), very low density lipoproteins (VLDL),
triglycerides (TG), values of atherogenic coefficient (AC), insulinemia, С-peptidemia,
insulin resistance (IR) the level of glycated hemoglobin (HbA1c) in a sample of patients
with schizophrenia and in mentally healthy individuals.
Materials and methods: The frequency of carbohydrate metabolism disorders (CMD) was
studied. Fasting glycemia was determined, and in the presence of its violation, a glucose
tolerance test was performed. MS components were studied in patients with DM2,
plasma concentrations of TC, HDL, VLDL, TG, C-peptide (CP), insulin and HbA1c were
determined in patients with DM2, AC values and IR indices were calculated using
HOMA-IR and CARO criteria.
Results: CMD in schizophrenia are more common than among mentally healthy subjects,
amounting to 13.1% (p=0.02), and the main condition here is a significant number of
individuals with impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT)
among women (CMD p=0.01; IGT p<0.001; IFG p=0.03). A feature of psychiatric
sampling is a decrease in HDL by 16.4% (p=0.03) and an increase in AC by 52%
(p=0.02). Mentally ill men with MS are characterized by a significantly large value of AC
(p=0.019), insulinemia (p=0.02), CP level (p=0.02), HOMA-IR (p=0.01) and CARO
(p=0.04) values than in mentally ill patients with DM2 without MS. In comparison with
the control, regardless of gender, the schizophrenic patients with DM2 have significantly
lower values of insulin (p=0.03), C-peptidemia (p=0.04) and IR, according to the criteria of
HOMA-IR (p=0.01) and CARO (p=0.03).

Phytochemical analysis of α-amylase- inhibiting secondary metabolites of endophyte Penicillium brevicaule alba Thom

Gulyamova T.G.; Nasmetova S.M.; Ruzieva D.M.; Mukhammedov I.I,; Kadyrova G.Kh.; Karimova F. A.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 829-836

The present work was aimed to identify phytochemicals in methanol extract P. brevicaule alba Thom - CC200, obtained from C. cristata , by qualitative and TLC analysis and evaluation of α-amylase inhibitory activity in vitro. It was determined the presence in the extract of glycosides, terpenoids, and saponins. The partitioning of the extract by TLC showed that inhibition of enzyme activity at 50,3% and 37,6% is associated with two compounds of saponin nature.

CLINICAL AND X-RAY PECULIARITIES OF THE COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN COMBINATION WITH DIABETES MELLITUS

Jamshed Turdumatov; Gulshod Mardieva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 3009-3028

At present, the important role of comorbid diseases, including diabetes
mellitus, in the course of COPD has been determined. Concomitant diabetes
mellitus accelerates the progression of ventilation disorders and worsens the
prognosis, increasing the risk of mortality from COPD. Diabetes mellitus is
associated with COPD from 2 to 16%. Potential mechanisms underlying the
high incidence of the combined course of COPD and type 2 diabetes mellitus
include: chronic systemic inflammation, oxidative stress, and chronic
hyperglycemia.
Purpose. determination of clinical, functional and radiological features
of COPD in diabetes mellitus.
Materials and methods. We examined 75 patients and studied the
features of the course of COPD in combination with diabetes mellitus in
comparison with the results of examining patients with COPD and patients
with diabetes mellitus by X-ray and MSCT.
Results. Patients with COPD in combination with diabetes mellitus are
characterized by more pronounced respiratory failure and chronic cor
pulmonale, frequent exacerbations and more pronounced hypoxemia in
comparison with patients with COPD. Standard radiography did not reveal
pronounced differences between the examined groups of patients with COPD.
COPD is formed as a result of damage to the small bronchi, which determines
the characteristic clinical and radiological symptom complex. In the structure
of COPD, there is a pulmonary component and systemic manifestations that
aggravate the disease. The manifestations of diabetes mellitus are based on
micro- and macroangiopathies that affect pulmonary microcirculation.
Conclusions. Diagnostically significant for COPD during MSCT is a
symptom of expiratory "air trap", combined with expansion and deformation of
the bronchi, up to bronchioectasis. At MSCT in patients with COPD and
diabetes mellitus, pathognomic changes characterizing microangiopathy:
dilated parenchymal vessels, focal-like shadows of vascular origin with a
diameter of 2-5 mm, a clear-cut shape of the vessels, which are considered as a
consequence of specific microangiopathy and fibrotic changes in COPD.

ANALYSIS OF ECONOMIC LOSSES DUE TO DIABETES MELLITUS IN NATIONAL HEALTH INSURANCE PARTICIPANTS

Ani Pujiningrum; Thinni Nurul Rochmah

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 5, Pages 821-830

The result of Indonesia Basic Health Research in 2018 showed an increase in the percentage of people with diabetes mellitus. This study aimed to analyze economic losses due to diabetes mellitus in National Health Insurance (NHI) participants with insurance fee waiver (IFW) and non-insurance fee waiver (IFW). This research was a quantitative study with a cross-sectional design. The sample of this study was 17 patients with IFW and 15 patients with non-IFW. The instrument used in this study was a questionnaire consisting of questions about the variable characteristics of the respondents and the direct and indirect costs that should be paid for treatment. Economic losses due to diabetes mellitus were analyzed through direct and indirect total costs.The economic loss for patients with IFW was IDR 5,572,366. Meanwhile, the economic loss for patients with non-IFW was IDR 2,989,984. So, the biggest economic loss due to diabetes mellitus was found in patients with IFW. This was very high when compared to their average income of around IDR 634,375. This can happen because the NHI participants have not taken full advantage of the use of NHI.

Effect of BergeniaLigulata on Metabolic Enzymes of Glucose Homeostasis and Its Correlation With Antioxidant Activity in Streptozotocin Induced Diabetic Rats

Nagarani K; Swathi P; Eswar Kumar K

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 187-202

Abstract: Diabetes mellitus is characterized by loss of glucose homeostasis as a result of impaired secretion and function of insulin. The present study was designed to evaluate the role of flower extractof Bergenialigulataagainst diabetesin Streptozotocin induced diabetic rats. Albino Wistar rats weighing 120-150g of either sex were selected for the study.After a week of acclimatization, the rats were subjected to overnight fasting. Diabeteswas induced by intraperitoneal injection of Streptozotocin, freshly dissolved in citrate bufferpH 4.5.In the present study the STZ control animals showed enhanced gluconeogenic enzymes and diminished glycolytic enzymes there by it disturb the glucose homeostasis and diminished insulin production leads increased serum glucose levels. Treatment with flower extract ofBergenialigulata(AFBL) showed significant balancing of glucose homeostasis through reduction in gluconeogenic enzymes and elevation of glycolytic enzymes.The selected flower extract ofBergenialigulata(AFBL) showed in vivo antioxidant activity, antihyperglycemic activity, hepatoprotective activity, nephroprotective activity and finally glucose homeostatic activity might be due to the potent phytoconstituents present in the selected flower extract

New Aspects in the Study of Clinical and Morphological New Aspects in the Study of Blood in Type II Diabetes Mellitus

Tatyana V. Pavlova; Vladimir F. Kulikovskij; Anton N. Kaplin; Irina I. Povalyaeva; Lyudmila O. Zemlianskaia; Lyubov A. Pavlova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 128-133

The aim of the research was to study red blood cells in type II diabetes mellitus (DM),
both an independently occurring disease, and in combination with hypertension, using
innovative research methods (atomic force and scanning electron microscopy with
elemental analysis). In the course of the study, we observed 20 patients aged 40 to 50
years. All of them were divided into groups of 5 people: without somatic and endocrine
pathology and infectious diseases; with moderate type II DM; stage II hypertension;
with a combination of type II DM and hypertension. Each has passed the necessary set
of generally accepted clinical and laboratory examination methods together with related
specialists (therapist, endocrinologist, neurologist, ophthalmologist). Blood was taken
from each patient for subsequent light, atomic force and scanning electron microscopy.
A morphometric analysis of the tissues in the Ntegra-Aura instrument was also
performed. We observed the most pronounced changes in the structure of erythrocytes
in people with a combination of type II DM and hypertension: the number of
degenerative forms increases sharply, and the number of discocytes decreases. In this
regard, such altered red blood cells can’t perform their functions in full. The article
substantiates the possibility and future prospects of using atomic force and scanning
electron microscopy with elemental analysis for independent type II DM, and in
combination with arterial hypertension.

New Aspects in the Study of Clinical and Morphological Features of Uterine Blood Flow in Type 1 Diabetes Mellitus in the Mother

Tatyana V. Pavlova; Anton N. Kaplin; Lyudmila O. Zemlianskaia; NataliaB. Pilkevich; LyubovA. Pavlova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 105-109

The aim of the study was to develop new approaches to the study of modern aspects of
the clinical and morphological features of uterine blood flow in type I diabetes mellitus
(DM) in the mother. Under our supervision, there were 40 pregnant women with type I
DM. Clinical examination methods generally accepted in obstetric practice were used to
assess the condition of the fetus, placenta, and blood flow in the fetal vessels and uterine
arteries. Light microscopy, atomic force microscopy (AFM), and scanning electron
microscopy (SEM) of 2 uterine fragments obtained during cesarean section were
performed. Samples were examined using a FE1 Quanta 200 3D scanning microscope,
analyzed, and morphometric and imaging were performed. Processing AFM images was
formulated using the NOVA software (NT-MDT, Russian Federation). Results obtained
allow us to judge the adverse effect of diabetes on the mother's body during pregnancy
and childbirth. Among the complications of pregnancy, it should be noted: the state of
preeclampsia (8%), fetoplacental insufficiency (88%), the threat of abortion (52%),
polyhydramnios (25%).Morphologically, we revealed plethora of the endometrium. A
change in the shape of the myometrium with the presence of fragmentary destructive
changes in the myometrium, including focal necrosis and damage to the vascular system
of the pregnant uterus. The paper substantiates the possibility of using scanning electron
and atomic force microscopy as express methods for morphofunctional diagnosis of a
woman's condition in pregnancy pathology

FEATURES OF DIAGNOSTICS OF CARDIOVASCULAR AUTONOMOUS NEUROPATHY OF CHILDREN WITH DIABETES MELLITUS TYPE 1

Dilfuza Ashurova; Azizakhon Sadirkhodjaeva; Malika Khaldarbekova; Zukhra , Shermatova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2382-2392

Abstract. The presence of cardiovascular autonomic neuropathy (CAN) significantly
worsens the prognosis and course of the underlying disease. So in patients with diabetes
mellitus (DM) and CAN, the mortality rate for 5 years is five times higher compared to
patients without this complication. Due to the fact that CAN is closely associated with
cardiovascular pathology, many authors consider CAN as a significant factor in
cardiovascular risk. Purpose. To establish clinical, functional and metabolic changes in
diabetic autonomic cardiovascular neuropathy in children with type 1 diabetes. Materials and
methods research. The total number of patients studied by us was 114 children with type 1
diabetes mellitus aged 4 to 18 years. We conducted laboratory and instrumental research
methods. Laboratory methods: general clinical research (general analysis of blood and urine,
studies of blood sugar), biochemical methods (total blood protein, bilirubin, cholesterol,
triglycerides, creatinine, urea, electrolytes, glycated hemoglobin), 24-hour heart rate
monitoring with circadian index estimation was used and parameters of time and frequency
analysis of heart rate variability. Conclusion diabetic autonomic cardiovascular neuropathy in
children with type 1 diabetes is characterized by the development of tachyarrhythmic rhythm
disturbances, as well as the formation of rigidity of the heart rhythm and a decrease in the
sensitivity of the sinus node to parasympathetic influences according to a temporary analysis
of daily monitoring of heart rhythm.

PRION PROTEINS AND DIABETES MELLITUS - A REVIEW

S. Vidyashri; Jayalakshmi Somasundaram; MP Brundha

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1520-1528

The objective of this article is to provide an overview on the association between Prion proteins and diabetes mellitus which is important so as to understand the aetiology of diabetes mellitus and provide better treatment plans. Prions are misfolded proteins Which have the ability to transmit their misfolded structure to normal variants of the same protein. Prions form abnormal aggregates of protein known as amyloids. Islet amyloid polypeptide, IAPP, is a precursor protein which causes islet amyloid polypeptide amyloidosis, AIAPP, and is said to lead to type two diabetes. Prion aggregates are generally stable and resist proteolysis. Diabetes mellitus is a group of metabolic disorders characterised by high blood sugar level over a long period of time. It is mainly caused by insulin deficiency or resistance. Prion mediated diseases are generally neurodegenerative disorders such as Kuru, Parkinson's disease, Alzheimer's disease etc. There are two isoforms of prions which are PrP and PrPSc. PrPSc is the infective form and is capable of converting PrPC into infective state. In this review, we discuss the association of prion protein with diabetes mellitus, the structure and propagation of Prion proteins and the link between diabetes mellitus and other prion mediated diseases via cross seeding. A review has been done in order to understand and analyse the association between prion protein and diabetes mellitus by retrieving a minimum of 20 articles from various data search engines including pubmed, Google scholar, MESH, core, bioRXiv, Semantic scholar and so on. This review gives a clear understanding of prion proteins, their structure, propagation and disease causing abilities. It is also analyzed that diabetes mellitus could not be just a disease which is caused by insulin deficiency or resistance but could also be the consequence of protein misfolding.

ORAL LICHEN PLANUS AND ITS ASSOCIATION WITH DIABETES MELLITUS - A RETROSPECTIVE STUDY

H.Firdus Fareen; Deepika Rajendran; Sri. Rengalakshmi

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 945-954

Lichen planus is a chronic inflammatory mucocutaneous disorder of unknown origin. OLP has been reported to be associated with different medical conditions such as diabetes, hepatitis C infection, liver disease, and oral cancer. This study was aimed to evaluate the association of oral lichen planus among diabetes mellitus patients. In this study from June 2019 to March 2020, the clinical records of patients with oral lichen planus were evaluated. Data of age, gender, presence of diabetes mellitus and clinical variants of oral lichen planus were obtained from the records of the private dental college. Chi-square test was used to determine correlation between variables, while the Chi-square test for trends was used to assess the frequency of oral lichen planus patients with diabetes mellitus. The prevalence of oral lichen planus patients with diabetes mellitus was found to be 24.5% with mean age of occurrence was 50-73 years (47.2%) with higher incidence among females (66%). Erosive lichen planus was observed to be the most frequent form of oral lichen planus (49.1%) followed by reticular form (39.6%) and others. The results of this study shows that there was no statistical significant difference seen in patients with oral lichen planus among diabteic mellitus patients (p value >0.05). From the above study it can be concluded that there is no apparent association of diabetes mellitus with oral lichen planus due to the limitation of small sample size as the data was not location specific in this study.There is a need for more studies to be conducted with specific designs such as cohort and case-control studies, especially with larger sample size and involving other perspectives which could be useful in preventing and reducing the incidence of these lesions among diabetes mellitus patients.

RETROSPECTIVE STUDY ON BROAD SPECTRUM ANTIBIOTICS USED FOR DIABETIC AND NON DIABETICS PATIENTS

Amina Mehrin Bano; Dr.Hemavathy O.R; Sri Rengalakshmi

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 955-962

Orofacial infections of odontogenic origin have long plagued mankind. The discovery of the miracle drug
by fleming in the year 1928 and the routine use of penicillin after the landmark discovery of the powder
form of the antibiotic by florey and chain leading to significant change in the management of odontogenic
infection .The spread of infection is governed by factors such as impaired host defence, the virulence of
microorganism, functional abnormalities of the host and a lack of or delayed treatment. the microbiology
of odontogenic infections in diabetic and non-diabetic individuals has been found to be variable. Though
the effects of diabetes can affect infection severity , length of hospital stay, susceptibility to antibiotics
and outcome of treatment is unassured . Differentiation in antibiotics prescribed is also observed.The aim
of the study was to analyse the prevalence of the use of antibiotics among diabetic and non-diabetic
patients in a south indian dental university clinic . The list of all diabetics and non diabetics patients
treated for pain, dental infections , swelling were retrieved by reviewing 86000 patient records who have
visited the hospital during the study periods from june 2019 to march 2020 from the university
database.Data tabulation was carried out in Excel. The data was imported and transcribed in Statistical
Package for Social sciences version 16(SPSS,IBM corporation). Descriptive analysis was carried out.A
total of 9128 patients were included in the study based on treatment done of which 580 patients(6.3%) had
diabetes mellitus. Only 3.5 % of the male population and 2.8% of the female population has
diabetes.Amoxicillin 93.2% was found to be the most frequently prescribed antibiotics among nondiabetic
patients and diabetics patients 1.6% .A combination of metronidazole and amoxicillin was
prescribed to 0.5% of the whole study population .A combination clavulanic acid and
amoxicillin(augmentin )was prescribed to 4 % of the total diabetic study population and 0.4% of the nondiabetic
study population that is about.The relation between the diabetic status of a patient and the
antibiotic prescribed showed a significant statistical relationship in a Pearson's Chi square test with p value
of 0.001(p<0.005).The prescribing practises in dental offices can be improved by increasing awareness
among dental practitioners about the recommended guidelines for prescribing antibiotics . The most
commonly prescribed antibiotics among diabetic patients was Augmentin (4.08%) and for non diabetics it
was amoxicillin (93.25%). .