Online ISSN: 2515-8260

Keywords : Uterus

Assessment of non- neoplastic and neoplastic lesions of uterine cervix

Dr. Priyankar Sharma, Dr. Ankit Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 1882-1886

Background: Histopathological studies of the cervix along with clinical correlation is very important for definitive diagnosis in diseases of the cervix. The present study was conducted to assess non neoplastic and neoplastic lesions of uterine cervix.
Materials & Methods: 78 specimens received from hysterectomy, cervical biopsy, cervical polypectomy from department of obstetrics & gynecology were formalin fixed & paraffin embedded tissue sections were used for microscopic study. Microscopic findings were recorded and histopathological diagnoses were made.
Results: Cervical specimens were 13 cervical biopsy, 60 hysterectomy and 5 polypectomies. The difference was significant (P< 0.05). Non- neoplastic inflammatory lesions were seen in 55 and non-neoplastic cervical glandular lesions in 10. Neoplastic lesions were benign in 8, precursor lesions in 3 and malignant lesions in 2 cases. The difference was significant (P< 0.05). Inflammatory lesions were acute cervicitis in 5, chronic non- specific cervicitis in 30 and chronic papillary endocervicitis in 20 cases. Benign lesions were endocervical polyp in 4, fibroepithelial polyp in 2 and leiomyomatous polyp in 2 cases. The difference was significant (P< 0.05).
Conclusion: Histopathological examination of biopsy specimen is gold standard for the diagnosis. Cervical malignancies are most common malignancies of female genital tract

To study the clinical and histopathological findings on hysterectomy

Dr Razia Siddiqui, Dr Shruti Agarwal, Dr Priyanka Tiwari, Dr Girish Kumar Pathak

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 299-304

Background: Hysterectomyare mostlycommon performed in the gynecological procedure for clinical problem in its treatments includes fibroids, prolapse, adenomyosis, endometriosos. Hysterectomy is performed worldwide in women at 30- 55 years of age. Aim and objectives to indicate the diagnosis to performed hysterectomy in patients and complications associated undergoing hysterectomy.
Methods: Total 255 patients undergone hysterectomy in the hospital was studied and analysed it clinical indications of surgery and complication of it, surgical specimens were sent for histopathology and report.
Results: The study shows thathysterectomy was performed in the major diagnosis of uterine prolapse (33.50%), leiomyoma (45.50%), adenomyosis (12.50%) while the report specimens also showed it. The diagnosis before the hysterectomy was confirmed by histopathology. There was no major complications were observed in the patients undergoing hysterectomy as this procedure is widely used for gynecological problems.
Conclusions: The study shows the data of patients’ trends of the hysterectomy and diagnosis that leads to perform hysterectomy was analyzed by histopathological finding in the patients. Complications were negligible in the hysterectomy and safe procedure

A Retrospective assessment of the histo-morphological diversity of various lesions of the uterus, cervix and adnexa

Dr. Vani H Patel, Dr. Maulik K Mehariya, Dr. Vishal S Patel

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 90-95

Aim: To study the histo-morphological diversity of various lesions of the uterus, cervix and adnexa.
Materials and Methods: A Retrospective Histopathological study of 609 cases of nonneoplastic and neoplastic lesions of hysterectomy specimens was conducted in Department of Pathology, over the period from June 2015- May 2017. Hysterectomy specimen with or without unilateral or bilateral adnexa received in the department. The specimens were analyzed in detail macroscopically for various parameters like size, external surface, and consistency and cut sections.
Results: Atrophic changes were seen in 13.46% cases. Endometrial hyperplasia was seen in 26 cases. Among the neoplastic lesions 2.46% cases were endometrial polyps with only 3 cases of malignancy forming 0.49%. Among the histologic types of lesions of myometrium, majority were Leiomyoma (27.59%). Leiomyoma and Adenomyosis were seen in 55 cases (9.04%). Adenomyosis was seen in 22.00%. Chronic cervicitis was seen in 36.07% cases and chronic cystic cervicitis in 6.21% of cases. Nabothian cyst were seen in 124 cases (20.80%). 19.80% cases showed Squamous metaplasia. Out of 188 Ovarian lesions, 167 (88.83%) were non-neoplastic lesions and 21 (11.17%) were neoplastic lesions. Fallopian tube pathology included chronic salpingitis in 2 cases, paratubal cyst in 07 cases. 69.4% of cases show unremarkable fallopian tubes.
Conclusion: The present study provides awareness into the wide range of histopathological patterns of lesions in uterus and cervix in hysterectomy specimens. It aids to appropriate management in the postoperative period.



European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 4974-4980

INTRODUCTION-uterine fibroids are common tumor of uterus, seen in reproductive age group. Fibroids during pregnancy produce special challenges during labour. Small fibroids with minimal symptoms treated with medical management, while large, multiple fibroids with pressure symptoms require surgical management. Fibroids during pregnancy produces special challenges during labour.
AIMS & OBJECTIVES –To study and analyse the Risk factors associated withfibroids, Clinical features according to different type offibroid, Different types of management of fibroid.
METHODOLOGY- fibroid cases were diagnosed clinically and with ultrasonography. Details of clinical examination findings, investigations and treatment modalities used were noted. Difficulties during surgery and methods to overcome were studied.
Histopathology details of specimen and other associated findings were studied.
RESULTS- Fibroids are Commonly seen in reproductive age group showing 45.5% cases. Majority cases are multipara seen in 79.35% cases and 5.14% cases are pregnant patients with fibroid. Intramural fibroid was seen in 60% and presented with menorrhagia (73%) and dysmenorrhea (50.5%). Fibroids presented with menstrual symptoms were seen in 96.15% cases. 61.7% cases underwent surgical management in that Total Abdominal Hysterectomy alone constitute 76.19%. neglected fibroids were common in rural areas making surgical management more common.
CONCLUSIONS- Pre-operative adequate preparations with general build-up for anesthesia and surgery, imaging studies, ureteric stenting where-ever required, use of GNRH analogues and following the principles of Fibroid surgery, made successful surgeries with no surgical morbidity and mortality. Caesarean section is common mode of delivery in fibroids in pregnancy with no complications.

A cross-sectional prospective assessment of the sonographic morphology of pelvic masses and its correlation with the histopathological diagnosis

Dr. Govind Khatri, Dr. Monika Sharma, Dr. Aditya Kaul, Dr.Ankitaa Thakral, Dr. Pratibha Gupta, Dr. Naresh Tripathi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1142-1150

Aim: To evaluate the sonographic morphology of pelvic masses and to correlate with the
histopathological diagnosis of the patients who underwent surgical intervention.
Material and Methods: A cross-sectional prospective study was conducted in the
Department of Radiology Maharishi Markandeswar Medical College and Hospital
Kumarhatti, Solan,Himachal Pradesh for the period of 1 year. Total 100 female patients with
Gynecological masses using high resolution ultrasonography and findings correlated with
histopathology or serial sonographic examination.
Results: Majority of the patients were in the age group of 40-50 years with mean age of 36.3
years. The minimum number was in the age group of below 20 years. The most common
chief complaint of female patients enrolled in our study was pelvic pain 36 (36%) followed
by pain and palpable mass 16(16%).Menstrualirregularity, menorrhagia, post-menopausal
bleeding, infertility, and amenorrhea were the other less common complaints in the female
patients of our study. Out of 100 patients evaluated by ultrasonography 25 (25%) were having
ovarian pathologies and 45(45%) were having uterine pathologies. Eleven patients presented
with localized collection in the fallopian tube pathologies. Few cases there were involvement
8(8%) of vagina. Fibroids were the most common uterine masses.
Conclusion: The USG is most commonly preferred imaging tool to evaluate gynecological
masses. It’s important to differentiate gynecological and non-gynecological masses on
sonography for accurate management of the patient.


Dr Poonam Ohri, Dr Niveditha Basappa, Dr Kulwinder Kaur, Dr Manasi Kohli, Parushi Kohli, Dr Prabnoor Kaur

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 282-291

Background: The desire to procreate is universal phenomenon. Childlessness is considered
as a curse in many societies and is one of the causes of marital breakups. WHO has defined
infertility as ‘Failure to conceive over 12 months of uninterrupted sexual practice. USG has
become a well-established technique for imaging ovarian and uterine pathologies. Methods:
This is a hospital based cross sectional, observation study,included total of 51 cases. The
patients with chief complaints of infertility presenting to gynaecology OPDs were referred to
the department of Radiodiagnosis,Guru Nanak Dev Hospital, Amritsar and all patients were
subjected to transabdominal ultrasonography using 3.5 MHz sector transducer. Results: Out
of 51 cases studied, 35 were of primary infertility and 16 were of secondary infertility.
Duration of infertility varied from 1.75- 17 years in patients with primary infertility and 2-10
years in patients with secondary infertility,maximum cases between 2-4 years.. Nonspecific
enlargement of uterus on one case, 3 with fibroid, 3 with endometrial calcification, one with
infantile uterus and one bicornuate uterus. Ovaries were normal in 37 cases, abnormal in 9
cases, not visualized in 3 cases on left and 1 on right side. Left ovary enlarged in one case.
Ovarian cyst in 3 cases, T.O masses in 5 cases and PCOD in one case. Fluid in POD in 4
cases.Conclusion: It is concluded that ultrasound is very helpful in assessment of uterus and
adnexal pathologies. USG is non-invasive, cheap, acceptable, easily available modality. It can
diagnose structural abnormality and helps in making diagnosis of etiologic factor in patients
of infertility and also in management and follow up of patients of infertility.

New Aspects in the Study of Clinical and Morphological Features of Uterine Blood Flow in Type 1 Diabetes Mellitus in the Mother

Tatyana V. Pavlova; Anton N. Kaplin; Lyudmila O. Zemlianskaia; NataliaB. Pilkevich; LyubovA. Pavlova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 105-109

The aim of the study was to develop new approaches to the study of modern aspects of
the clinical and morphological features of uterine blood flow in type I diabetes mellitus
(DM) in the mother. Under our supervision, there were 40 pregnant women with type I
DM. Clinical examination methods generally accepted in obstetric practice were used to
assess the condition of the fetus, placenta, and blood flow in the fetal vessels and uterine
arteries. Light microscopy, atomic force microscopy (AFM), and scanning electron
microscopy (SEM) of 2 uterine fragments obtained during cesarean section were
performed. Samples were examined using a FE1 Quanta 200 3D scanning microscope,
analyzed, and morphometric and imaging were performed. Processing AFM images was
formulated using the NOVA software (NT-MDT, Russian Federation). Results obtained
allow us to judge the adverse effect of diabetes on the mother's body during pregnancy
and childbirth. Among the complications of pregnancy, it should be noted: the state of
preeclampsia (8%), fetoplacental insufficiency (88%), the threat of abortion (52%),
polyhydramnios (25%).Morphologically, we revealed plethora of the endometrium. A
change in the shape of the myometrium with the presence of fragmentary destructive
changes in the myometrium, including focal necrosis and damage to the vascular system
of the pregnant uterus. The paper substantiates the possibility of using scanning electron
and atomic force microscopy as express methods for morphofunctional diagnosis of a
woman's condition in pregnancy pathology

The Relevance Of Endoscopic Examination And Morphological Features Of Stomach Cancer With Concomitant Uterine Endometriosis

Khatamova M.T.; Bobokulova S.B.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 3353-3356

Introduction: According to the Ministry of Health of the Republic of Uzbekistan, in terms of frequency of occurrence, stomach cancer is in second place after breast cancer. Result: Unfortunately, in more than 50% of cases, the primary detection of endometriosis of the uterus in these patients occurs in advanced stages, when their treatment is rather difficult and in most cases is palliative in nature, aimed at some increase in life expectancy and improvement of its quality.