Online ISSN: 2515-8260

Keywords : Insulin


Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder

Oleg V. Ermilov; Andrey Yu. Tretyakov; Lyubov V. Romasenko; Nina I. Zhernakova; Elizaveta S. Rudycheva; Inna V. Tikhonova; Irina A. Misan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 122-127

Objective: To describe the features and mechanisms of development of metabolic
syndrome (MS), type 2 diabetes melitus (DM2) and intermediate states of glycemia in
psychosis the occurrence of these disorders, the values of total cholesterol (TC),
fractions of high density lipoproteins (HDL), very low density lipoproteins (VLDL),
triglycerides (TG), values of atherogenic coefficient (AC), insulinemia, С-peptidemia,
insulin resistance (IR) the level of glycated hemoglobin (HbA1c) in a sample of patients
with schizophrenia and in mentally healthy individuals.
Materials and methods: The frequency of carbohydrate metabolism disorders (CMD) was
studied. Fasting glycemia was determined, and in the presence of its violation, a glucose
tolerance test was performed. MS components were studied in patients with DM2,
plasma concentrations of TC, HDL, VLDL, TG, C-peptide (CP), insulin and HbA1c were
determined in patients with DM2, AC values and IR indices were calculated using
HOMA-IR and CARO criteria.
Results: CMD in schizophrenia are more common than among mentally healthy subjects,
amounting to 13.1% (p=0.02), and the main condition here is a significant number of
individuals with impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT)
among women (CMD p=0.01; IGT p<0.001; IFG p=0.03). A feature of psychiatric
sampling is a decrease in HDL by 16.4% (p=0.03) and an increase in AC by 52%
(p=0.02). Mentally ill men with MS are characterized by a significantly large value of AC
(p=0.019), insulinemia (p=0.02), CP level (p=0.02), HOMA-IR (p=0.01) and CARO
(p=0.04) values than in mentally ill patients with DM2 without MS. In comparison with
the control, regardless of gender, the schizophrenic patients with DM2 have significantly
lower values of insulin (p=0.03), C-peptidemia (p=0.04) and IR, according to the criteria of
HOMA-IR (p=0.01) and CARO (p=0.03).

Mathematical modeling of Glucose, Insulin, -Cell Mass: Homotopy Perturbation Method Approach

K. Saranya; T. Iswarya; V. Mohan; K. E. Sathappan; L. Rajendran

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 3513-3530

kinetics. This paper provides the theoretical and numerical solutions of the
nonlinear differential equation system.The homotopy perturbation method (HPM) is used to find
analytical expressions of the glucose, Insulin, and  -cell mass respectively. A comparison is
also provided between analytical approximation and numerical simulation. A reasonable
agreement between theoretical and simulation results is founded.