Online ISSN: 2515-8260

Keywords : Glycated hemoglobin

Assessment of correlation between HbA1cand microalbuminuria among diabetics

Jaikirat Singh Gugnani, Abhishek, Harkamalpreet Kaur, Yooghetha Mookaiyan Sundaramurthy, Mansour Shirzai, Mahum Ali

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 1012-1016

Background: Diabetes is an important metabolic disorder worldwide and is characterized by a variable degree of insulin resistance, impaired insulin secretion, and increased glucose production. The present study was conducted to assess the correlation between HbA1cand microalbuminuria among diabetics.
Materials & Methods:
Results: Group I had 20 males and 20 females and group II had 18 males and 22 females. In group I and group II, mean HbA1c (%) was 7.9 and 5.2, fasting blood sugar (FBS) (mg/dL) was 174.2 and 86.2, postprandial blood sugar (PPBS) (mg/dL) was 258.6 and 124.8, blood urea (mg/dL) was 28.4 and 14.2, serum sodium (mEq/L) was 127.2 and 138.9, serum potassium (mEq/L) was 2.7 and 3.8, serum creatinine (mg/dL) was 1.5 and 0.84 and microalbuminuria (mg/L) was 43.6 and 10.6. The difference was significant (P< 0.05). There was positive correlation of microalbuminuria and duration of DM (r- 0.521, p- 0.03), microalbuminuria and FBS (r- 0.316, p-0.05), microalbuminuria and PPBS (r- 0.412, p- 0.02) and microalbuminuria and HbA1c (r- 0.833, p-0.01).
Conclusion: The prevalence of microalbuminuria in diabetic patientswas found to be high. There was a correlation between glycated hemoglobin and microalbuminuria among diabetics.

Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder

Oleg V. Ermilov; Andrey Yu. Tretyakov; Lyubov V. Romasenko; Nina I. Zhernakova; Elizaveta S. Rudycheva; Inna V. Tikhonova; Irina A. Misan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 122-127

Objective: To describe the features and mechanisms of development of metabolic
syndrome (MS), type 2 diabetes melitus (DM2) and intermediate states of glycemia in
psychosis the occurrence of these disorders, the values of total cholesterol (TC),
fractions of high density lipoproteins (HDL), very low density lipoproteins (VLDL),
triglycerides (TG), values of atherogenic coefficient (AC), insulinemia, С-peptidemia,
insulin resistance (IR) the level of glycated hemoglobin (HbA1c) in a sample of patients
with schizophrenia and in mentally healthy individuals.
Materials and methods: The frequency of carbohydrate metabolism disorders (CMD) was
studied. Fasting glycemia was determined, and in the presence of its violation, a glucose
tolerance test was performed. MS components were studied in patients with DM2,
plasma concentrations of TC, HDL, VLDL, TG, C-peptide (CP), insulin and HbA1c were
determined in patients with DM2, AC values and IR indices were calculated using
HOMA-IR and CARO criteria.
Results: CMD in schizophrenia are more common than among mentally healthy subjects,
amounting to 13.1% (p=0.02), and the main condition here is a significant number of
individuals with impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT)
among women (CMD p=0.01; IGT p<0.001; IFG p=0.03). A feature of psychiatric
sampling is a decrease in HDL by 16.4% (p=0.03) and an increase in AC by 52%
(p=0.02). Mentally ill men with MS are characterized by a significantly large value of AC
(p=0.019), insulinemia (p=0.02), CP level (p=0.02), HOMA-IR (p=0.01) and CARO
(p=0.04) values than in mentally ill patients with DM2 without MS. In comparison with
the control, regardless of gender, the schizophrenic patients with DM2 have significantly
lower values of insulin (p=0.03), C-peptidemia (p=0.04) and IR, according to the criteria of
HOMA-IR (p=0.01) and CARO (p=0.03).