Online ISSN: 2515-8260

Keywords : genetic polymorphism

Study Of Genetic Polymorphism In Oxidative Stress Related Genes And Their Association With Gastrointestinal Cancer: A Case Control Study From Rural Population Of South Western Maharashtra

Madhavi N. Patil; Anand Gudur; Rashmi Gudur; Satish Kakade; Sandeep Kadam; Suraj Pawar; Kailas D. Datkhile

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 42-52

Oxidative stress is known to be one of the major factors involved in the development and progression of cancer. Superoxide dismutase and Catalase plays an important role in the primary defence against oxidative stress. The present study was therefore undertaken to investigate the association between polymorphism of superoxide dismutase (SOD1, SOD2, SOD3) and Catalase (CAT1 & CAT2) and the gastro intestinal cancer risk in the rural population of the south western Maharashtra. The present case-control study included 200 confirmed gastrointestinal (GI) cancer patients and 400 age and gender matched healthy controls. The polymorphism in the Superoxide Dismutase and Catalase genes was studied out by PCR-RFLP method. When we studied the genotypic frequency of SOD1, SOD2, & SOD3, SOD2 (rs1141718) showed the negative association with the GI cancer risk [OR: 0.3097, CI: 0.1727-0.5553, p <0.0001]. There was no significant association found between SOD1 & SOD3 of superoxide dismutase and CAT1 & CAT2 of Catalase gene polymorphism and susceptibility of GI cancer. The present study shows no significant association of SOD1 (G allele of rs 2070424), SOD3 (A allele of rs2536512), CAT1 (T allele of rs7943316) and CAT2 (rs1001179) with the development of gastrointestinal cancer in the rural population of south western Maharashtra from India. However, SOD2 (rs1141718) shows the negative association with the development of GI cancer.

Malat1 RNA Genetic Factor and T1 Bladder Cancer

Vladimir F. Kulikovsky; Viktor K. Gostishchev; Alexander F. Chernousov; Pavel G. Osipov; Andrey L. Yarosh; Uriy A. Hoschenko; Olesya I. Lokteva; Andrey A. Beresh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 141-145

Bladder cancer is the most common malignant tumor of the urinary tract. This disease
has a pronounced tendency to relapse and progress, is characterized by a severe course
and a high degree of disability. Non-invasive bladder cancer - superficial tumors of the
mucous membrane of the bladder with possible germination in the submucosal layer,
but without muscle invasion (pTa and pT1). Invasive bladder cancer - with germination in
the muscle layer (≥рТ2). Currently, there is an extensive literature on genetic data with
RMP T2-T4, but there is not enough information about the early form of RMP - T1. It
was discovered that almost 90% of the human genome is actively transcribed, while
only 2% are protein-coding genes, and the majority of the transcripts are non-coding
RNAs. Molecules of non-coding RNA, depending on their size, are divided by length. A
lot of data has been published regarding the effect of short variants of these molecules
on the development of oncopathology by inhibiting mRNA expression. At the same
time, we did not find large studies devoted to the study of the influence of long noncoding
RNAs. Also now, the MALAT1 dnaRNA is attracting the attention of scientists.
Concurrently, researchers are particularly interested in studying the relationship of single
nucleotide polymorphisms of the MALAT1 gene with the appearance of
oncopathologies of different localization, as well as the study of its association with
different characteristics and stages of the tumor process. In this study, we collected
overview data regarding the possible association of rs 3200401 polymorphism of the
MALAT1 gene in patients with a single focus and multifocal bladder cancer stage T1.

Hereditary Polymorphism Of The Sodium-Uretic Peptides System And Long-Term Results Of Coronary Artery Stenting

Botir T. Daminov; Bakhrom A. Alyavi; Shuhrat I. Azizov

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3519-3534

The point of the study was to decide the impact of hereditary polymorphism on the impacts of endovascular revascularization in patients with coronary heart disease, angina pectoris FC III-IV.
The research included 158 patients with coronary heart disease with angina pectoris of FC III-IV pressure (ladies 34 -21.52%). Upon consideration within the ponder, all patients experienced: Echocardiography, TLC, genotyping of 6 genes of the system of natriuretic peptides, coronary angiography and stenting of the coronary courses. For follow-up examination, patients were welcomed after a year. The study included echocardiography, TLC, stress echocardiography.
Hereditary investigation permits foreseeing the drawn out impact of coronary supply route stenting: the overall danger of coronary illness movement (as stress-incited ischemia) in patients with minor alleles is 2.12 occasions higher than in patients with prevailing homozygotes for qualities of the natriuretic peptide system.
The current examination found that the presence of minor alleles of qualities of the arrangement of natriuretic peptides is related with a more prominent pervasiveness of atherosclerotic injuries of the coronary bed, the movement of underlying and useful rebuilding of the heart. What's more, the presence of minor alleles lessens the drawn out adequacy of coronary revascularization, both in the part of coronary atherosclerosis and in the part of the utilitarian condition of the myocardium (movement of LV dilatation and preservation of the sleeping myocardium).