Online ISSN: 2515-8260

Keywords : WBC

Original research article: Study of hematological and biochemical Markers in COVID-19 patients admitted in a tertiary care centre of Middle Gujarat, India

Dr Sonal Lakum, Asma Shaikh, Dr Anant Marathe,Dr Rachana Patel, Dr Dipali Gavali

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 2028-2033

Background: COVID-19 pandemic originated in the city of Wuhan in Hubie province of China and within three months of its origin the disease extended to nearly 221 countries in the world.
Objective: The objective is Study of hematological and various biochemical Markers in COVID-19 patients admitted in a tertiary care centre .
Methodology: In this single-center study, records of 170  patients hospitalized with COVID-19 were studied for hematological profile and biochemical markers. Records of patients with laboratory-confirmed COVID-19 disease hospitalized between April  2020, to August  2020, were included in the analysis.
Result: A total of 170  patients were enrolled of Age Group  20-80 year of which 80% (136/170) were asymptomatic and 20% (34/170) symptomatic. 17% patients had co-existing illnesses. Clinical spectrum among COVID-19 patients varied from being asymptomatic to having symptoms like fever, dry cough, breathlessness with few progressing to respiratory failure and multi-organ failure. In our study, 96.0% (163/170) recovered while 4.0% (7/170) died. Mean age, total leucocyte count (TLC), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lactate dehydrogenase (LDH) ,Procalcitonin, CRP, D dimer of severely ill patients were significantly higher than those of patients with non-severe illness.
Conclusion: The clinicians may consider the hematological and biochemical parameters in the patients with COVID-19 in future decision-making.  Elevated NLR, TLC, LDH, C-Reactive Protein, Procalcitonin, D dimer and lymphopenia were seen in the symptomatic patients especially manifesting severe disease. Early intervention and periodic monitoring of these parameters in patients, especially with severe disease may help in improving disease outcome

A Prospective Study on Haemotological Profile of Sickle Disease

Dr Haseeb Ul Haq , Dr Raghunath S.V Dr V.Sushma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 2871-2875

Objectives and Aim: The aim of this study was to determine Haematological profile of Sickle cell disease (SCD) from Karimnagar Region, Telangana, India
Methods: This Prospective Cross-Sectional Study was conduct­ed in the Department of Paediatrics, Prathima institute of medical sciences, Karimnagar India, between June 2019-Feb 2020.37 children between the age of 6 years to 15 years
Results: A total of 37 children’s homozygous (SS) (mean age 11.6±3.4 years) for sickle cell anaemia was studied for their haematological parameters. Out of the total SS subjects, 26 were males and 11 were females
Conclusion: We conclude that moderate to severe anaemia with, low MCV and high HbF dominate the haematological profile

Analysis of the Dengue Infection, Occurrence and Hematological Profile of Dengue Patients in Dhaka City

Mohammad Zakerin Abedin; Md. Sifat Uz Zaman; Tasnim Ahmad; Md. Abdullah Al Maruf; Md Babul Aktar; Md. Fayez Ahmed; Md. Abu Sayeed Imran; Rubait Hasan; Pinki Akter; Md. Ekhlas Uddin

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1572-1578

In the tropical and subtropical area, dengue virus is mostly found. To the determination of the occur-rence of dengue viral infection and hematological profile of dengue infected peoples in the Dhaka city. A sum of 255 samples of blood from both sex and different age groups were collected in this research. Dengue nonstructural protein 1 (NS1) and complete blood count (CBC) test were performed for the study. During this study period, total 255 samples were tested. Among these, 67samples were diagnosed as positive. Seroprevalence of dengue was 26.30%. Out of 67 positive dengue patients, 41 (61.2 %) were male and 26 (38.8 %) were female. Dengue infection was observed more in 21 to 30years age group followed by above 40years and 16 to 20years but observed less in of 1st day to 5years followed by 11 -15years, then 6 -10years and 31 - 40years. It was seen that the >40years of age group had the maximum unit of cases having low platelet count followed by 21-30years and it was also seen that 21-30years of age group had the maximum range of cases having low WBC count followed by above 40years of age group. In our research, we showed thrombocytopenia (100000 - 150,000/μl) with leucopenia (White Blood Cells, WBC <5000/μl) in 8(26.6%) cases and thrombocytopenia (100000-150,000/μl) without leucopenia in 9 (24.3%) cases but thrombocytopenia (<100000/μl) with leucopenia (White Blood Cells (WBC) < 5000/μl) in 5(16.7%) cases and thrombocytopenia (<100000/μl) without leucopenia in 6 (16.2%) cases. Among 67 positive cases, we found that (26.6%) had DF and (16.7%) had DHF according to WHO classification. For validating more reliability, this research needs further work.