Online ISSN: 2515-8260

Keywords : Gene polymorphism

Relationship between the gene polymorphism of osteoprotegerin, serum osteoprotegerin level and chronic kidney disease in south Indian populations

Dr. Mohan R, Dr. Darshan Kumar HS, Dr. Suresh SR, Dr. Neethu C Annigeri

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1818-1824

Introduction: CKD-MBD is thus thought to be a major contributor to the high mortality among patients with CKD. The negative regulation of osteoclastic bone resorption exerted by OPG could increase BMD and bone volume by decreasing the active osteoclasts as demonstrated by in vitro studies
Methodology: This is an observational study with no interventions carried out on any subject. Furthermore, all the CKD individuals were made two groups based on the dialysis. Finally, the analyses was done between the predialysis, dialysis and control population to find the possible or potential diagnostic marker for CKD-MBD.
Results: Distribution of rs3102735genotypes between the non-dialysis and dialysis groups were not found significant differences for allelic (OR: 1.54, 95% CI (0.65-3.60)), genetic TT vs TC (OR: 1. 81, 95% CI (0.48-6.76) p=0.37) TT vs CC (OR: 1. 70, 95% CI (0.36-7.85) p=0.49) and dominant (OR: 1.77, 95% CI (0.57-5.50) p=0.32) models. Similarly, we have not found significant difference for rs3102735 in recessive model (OR: 0.72, 95% CI (0.16-3.09) p=0.662).
Conclusion: The serum OPG may be a useful biomarker for early diagnosis of CKD-MBD.

Impact of Gene Polymorphism of Lipoprotein Lipase on Atorvastatin Treatment Outcome in Ischemic Stroke Patient in Najaf Governorate

Sarah Ali Abbas; Ahmed M. AlMudhafar; Thekra A. Al-Kashwan; Hayder K Hasson; Adhwaa Hameed Jaber; Najah R Hadi

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 225-228

Background: Stroke was commonly identified as a neurologically impairment that occur in central nervous system on vascular basis as Acute focal injury. Statin (HMG-CoA reductase Inhibitor), clinical trials in many large scaled shown that in primary and secondary CVD the used of statin was declined rates of (CV). Human Lipoprotein Lipase (LPL) gene coding was place in short arm of chromosome in the p22 region of the same Chromosome and has nine introns and ten axons. Aim: The aim of the study is to find out effect of LPL gene polymorphism of response to atorvastatin treatment in patients with ischemic stroke. Patients and methods: Samples was Picking up from patients’ admission to at Middle Euphrates Center for Neurological Sciences in the main hospital for measurement of the lipid profile, molecular analysis study of genotyping and measurement of human lipoprotein lipase by ELISA technique. Result: There is good response to treatment and the response consider statistically significant, the best group response to treatment was homozygous mutation then Heterozygous mutation and the less group response was Homozygous normal, wild. Conclusion: The effect of drug on serum biomarker not affected by age except HDL (best result in age<60yr), and not affected by gender and weight state, while in consider to smoking and Hypertension TG (best response in non-smoker, hypertensive) and VLDL (best response in smoker, hypertensive) affected and in diabetic state the Cholesterol and TG affected on response (the best result in non-diabetic). Heterozygous mutation most distributed then homozygous normal and the less distributed was homozygous mutation.


Nigora Khodjaeva; Ulugbek Sabirov; Shahnoza Mavlyanova; Sevara Muminova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1732-1736

In patients with a genetic predisposition, associations of the mutant variants
Arg25Pro of the TGFb1 gene, A-8202G of the MMP9 gene and MMP1 1607G (9.6%),
associations of the mutations of the Arg25Pro gene of the TGFb1 gene, and A-8202G of
the MMP9 gene (5.8%) are mainly detected, associations of mutations of Arg25Pro genes
of TGFb1 and MMP1 1607G (3.8%), associations of mutations of A-8202G genes of
MMP9 and MMP1 1607G (15.4%) of the examined patients with photo-aging.