Online ISSN: 2515-8260

Keywords : cinnamaldehyde

Evaluation of the effect of cinnamaldehyde per se and its interaction with ondansetron on haloperidol induced catalepsy in albino mice

Dr. Ritesh Churihar, Dr Sapna Arun More, Dr. Pooja S. Mishra, Dr. Deepti Gupta

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 580-585

Background: The aim of this study is to evaluate the per se effect of cinnamaldehyde which
is obtained from bark oil of cinnamon tree and its interaction with ondansetron on catalepsy
in Swiss albino mice.
Methods: Haloperidol induced catalepsy model was used. A group of 36 healthy mice of
either sex weighing 20-30 grams were divided at random into six groups (n=6).
Cinnamaldehyde with 98 percent purity was obtained. Catalepsy was induced by haloperidol
(1mg/kg, i.p). Control group received tween-20 20% (10ml/kg, p.o), standard groups were
administered ondansetron (0.5mg/kg and 1mg/kg, p.o ), test groups received cinnamaldehyde
in strength of 100mg/kg, and 200mg/kg and combination group of ondansetron plus
cinnamaldehyde (0.5mg/kg + 100mg/kg) per oral, respectively.
Results: In this acute study, from 60 min onwards after haloperidol administration,
ondansetron at both doses (0.5 mg/kg and 1 mg/kg), showed significantly lower cataleptic
scores as compared to all groups. Cinnamaldehyde at both strengths did not show any
significant effect as compare to control at any point of time (P>0.05). Combination of
ondansetron 0.5 mg/kg with cinnamaldehyde 100mg/kg, showed significant increase in
cataleptic score as compared to ondansetron 0.5 and 1mg/kg alone (P>0.05). Which suggest
that cinnamaldehyde abolishes the protective effect of ondansetron in haloperidol induced


Shefali Arora; Mahak Gusain; Ravi Gunupuru; Rohit Kaushik; Pushpendu Sinha; Deepak Kumar

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2331-2345

Plants are the oxygen support for our planet and all living things. They can be considered as “mothers of medicine”. As mothers take care of a child, Plants do the same for all human beings and animals. Medicinal plants have therapeutic properties that produce a beneficial pharmacological effect on the animal and human body. In recent years plants are surveyed as new drugs and gain attention to the discovery of new bioactive compounds. Hippocrates quoted “Let thy food be thy medicine, and thy medicine shall be thy food”. The flavor, aroma, taste, and nutritional properties make the Cinnamon offers a wide range of health benefits. The present study explores the connection between the Cinnamon plant and medicine, our food, modern science