Online ISSN: 2515-8260

Keywords : Cataract

Effect of Cataract Surgery on Central Corneal Thickness and Visual Fields in Glaucomatous and Non-Glaucomatous Eyes: A Comparative Study in Rural Tertiary Care Hospital

Meenu Babber, Reena Sharma, Ravi Ranjan, Anuradha Gaur, Brijesh Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 3711-3720

Background: Cataract and glaucoma are both common conditions and are often present in the same patient. The incidence of these diseases increases with age. Besides vision impairment, these diseases are associated with decrement in quality of life (QOL). Objective: To study the effect of cataract surgery on Central Corneal Thickness and Visual Fields in glaucomatous and non-glaucomatous eyes.
Materials and Methods: We enrolled 60 patients with glaucoma and concomitant cataract (Group A) and 60 patients with only cataract (Group B) scheduled for phacoemulsification cataract surgery. A record was made which included number of anti-glaucoma medications, visual acuity (VA), intra-ocular pressure (IOP), Central corneal thickness (CCT), visual field (VF) analysis: mean deviation (MD) and pattern standard deviation (PSD). The patients were re-evaluated at 1st week,4th week and 3rd month after cataract extraction and the above parameters were again obtained to compare them with the baseline values.
Results: The mean age of patients is 50.70±8.42 years in Group A & 50.83±8.29 years in Group B. Following cataract extraction, VA improved while CCT changes were insignificant in both the groups. The VF analysis showed that there was an improvement in mean deviation and worsening in pattern standard deviation after the cataract surgery in glaucomatous patients. Similar result was seen for mean deviation in control group. But there was no effect of cataract surgery on pattern standard deviation in non-glaucomatous patients.
Conclusion: Cataract extraction proves to be a beneficial management in both glaucomatous and non-glaucomatous patients in terms of vision and mean deviation. PSD was not affected in non-glaucomatous patients.


Dr Arun Kumar Sharma,Dr. LalitKumar,Dr. Bhavit Roat

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2065-2070

Background: Phacoemulsification with PCIOL decrease the intraocular pressure proportional to
the intraocular pressure seen preoperatively. Various preoperative factors are associated with the
reduction of IOP postoperatively.
Aim: The present study was conducted to assess the cataract surgery phacoemulsification with
PCIOL implantation on intraocular pressure postoperatively and the to assess the relationship
between preoperative ocular parameters including AL ACD, AL, and CCT with IOP change
Methods:In 262 subjects from both the genders with cataract were treated surgically with
phacoemulsification and PCIOL implantation. Following surgery, all the subjects were followed
up on 1st operative surgical day and 1 month postoperatively for ocular biometric parameters and
reduction in IOP.
Results:BCVA in the study subjects via LogMAR chart was 1-0.76 preoperatively and was 0.16-
0 postoperatively. BCVA using Snellen chart was 72% preoperatively which reduced to 67%
postoperatively. ACD preoperatively was 3.25±0.26 which increased significantly to 3.64±0.29
(p<0.001). Mean IOP in the operated eyes was 13.42±1.98mm Hg which decreased
postoperatively to 11.50±1.68 significantly (p<0.001). It was seen that mean IOP preoperatively
was 13.46±1.96 mmHg which decreased postoperatively to 11.56±1.64 mmHg. The change in
mean IOP at 1 month recall was 1.92±0.59 mmHg. The IOP change at 1 month in percentage
was 14.11%. This change in mean Intraocular pressure was statistically significant with p<0.001.

A study of incidence of posterior capsular of opacification after cataract surgery based on square edge polymethyl methacrylate intra ocular lens

Dr. Rasna Sharma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1023-1030

Introduction: Cataract is one of the most common and established surgical procedure in
Opththalmology in the world with the posterior capsular opacification (PCO) as a very
common complication, which may be present in long term. This study was done to find the
incidence of the posterior capsular opacification after cataract surgery and implantation of
360 square edge PMMA posterior chamber IOL among the patients attending our tertiary care
Materials and Methods: The cataract surgery was done with a careful implantation of a
square edged single piece PMMA IOL within the capsular bag seeing that peripheral 1mm of
the anterior capsular rim covers the optic edge of the IOL. On the 1st postoperative day, the
cases were examined under slit lamp for any postoperative complications. The next visits
were conducted at day 7, 1 month, 3 months, 6months and 8 months. The best-corrected
visual acuity was tested using Snellen chart, both aided and unaided.
Results: Out of 50 patients included in the study, 21 (42%) were females and 29 (58%) were
males. The most common age group of all the patients was 61-70 years wherein 58.6% of the
males and 42.9% of the females were present. Of the total 50 eyes operated for cataract, 90%
of the patients had no posterior capsular opacification, while 4% had fibrous membrane type
of PCO and 6% had Elsching’s Pearl type of PCO.
Conclusion: The square edged PMMA IOL is quite effective in reducing the formation of
posterior capsular opacification after the cataract surgery

Prevalence of corneal astigmatism in patients before cataract surgery in Northern India

ArunKumar Singh, Kamaljeet Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10093-10101

Objective: To study the prevalence, amount and axis of pre-existing corneal
astigmatism in patients undergoing cataract surgery.
Methods: The study was carried out at a tertiary care ophthalmic institute in Prayagraj,
in patients admitted for cataract surgery from July 2017 to December 2017. In this
prospective study, patients aged 36-85 years of both genders were included and
statistically analysed. A Bausch and Lomb Manual keratometer was used for
measurement of keratometry. Only eyes without a previous history of ocular surgery or
any eye abnormality were included.
Results: Out of 997 patients,with-the-rule (WTR) astigmatism was found in 429 patients
(43%) and against-the-rule (ATR) astigmatism was found in 389 patients (39%) while
no astigmatism was found in 179 patients(18%).In females, WTR astigmatism was
found in 226 (41%) eyes; ATR astigmatism in 229 (42%) eyes; and no astigmatism in 94
(17%)eyes. In males, WTR astigmatism was found in 203 (45%) eyes; ATR astigmatism
in 160 (36%) eyes; and no astigmatism in 85 (19%) eyes. The most prevalent
astigmatism in this study was<1D (with average amount of astigmatism +0.80D.)
Conclusion:Most frequently observedpre-existing corneal astigmatism in this study is<1
D.WTR astigmatism is found to be more common in younger patients which shifts to
ATR astigmatism in older patients which is more evident in females. This can be easily
corrected with appropriate measures like limbal or corneal relaxing incisions,excimer
laser refractive procedures,femto laser assisted astigmatic keratectomy or toric IOL

Evaluation of the status of diabetic retinopathy after cataract surgery

Dr. Preeti Singh, Ankit Gupta

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 712-719

Diabetes mellitus (DM) affects about 400 million adults globally, a number that is predicted
to be doubled by 2035 according to the world health organization (WHO).When cataract
surgery is done on diabetic patient the status of retina and retrieval of vision depends on
severity of diabetic retinopathy and previous treatment received. In diabetic patients,
macular oedema after cataract surgery can be a frequent and complex problem, especially
in the patients with pre-existing diabetic retinopathy. The objective of present study is to
evaluate the status of diabetic retinopathy after cataract surgery. The hospital based
prospective, observational study was carried out. 50 diabetic patients underwent cataract
surgery between October 2017 to September 2018. All were studied postoperatively at 1
month and 3 months.
This study used OCT to evaluate macular oedema in patients which in turn helped to find
out the status of diabetic retinopathy. The present study does not show any progression in
diabetic retinopathy in the operated eyes over the short term follow up of 3 months. None
of the patients who were having no retinopathy pre-operatively developed retinopathy post

Catechin Regulates Reticulum Endoplasmic Stress in Rats Cataract Model Catechin in Cataract

Nugraha Wahyu Cahyana

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2396-2402

Background : Opacity that develops in the crystalline lens of the eye is called the cataract. Decrease amounts of GRP78 involved in the pathogenesis of cataracts by reticulum endoplasmic stress of lens epithelial cells. Aim : The aim of the study was to evaluate the effects of Catechin on sodium-selenite induced cataract formation and activities of GRP78. Methods : 19 μmol/kg of sodium selenite was injection by intraperitoneal to ten day-old Wistar rats. The rats were separated randomly in five groups (n = 5 in each group): a control group, and four cataract induction groups, treated with 0, 50, 100, 200 mg / kg catechin isolates. GMB4 Clone of Green Tea. By slit-lamp bio microscopic we performed degree of lens opacity and analysis of GRP78 by Enzyme-linked immunosorbent assay (ELISA). Results : Both eyes of all rats in Group 1 no cataract formation. 20% of group 2 were found grade 3 cataracts and the remaining four of five (80%) developed grade 4 cataracts. Cataract in the lens of all rats between group 2 and any eyes from groups 3 or 4 and 5 showed a significant difference (P = 0.022, 0.001, 0.001). The degree of cataract formation in groups 3, 4 and 5 decreased. Grp78 levels in Group I, Group III, Group IV and Group V were significantly higher than the mean lens levels in Group II (P <0.01). Conclusion : Reticulum endoplasmic stress in the lens that increased following cataract formation in rats was suppressed by catechin Isolate From GMB4 Clone Green Tea.