European Journal of Molecular & Clinical Medicine

Background:
Advanced intermittent hypoxia-normoxia KZ-001 (manufactured in Japan under the
Japanese Wellness Science and Technology) is a combination of a fine-tuned
hypobaric (hypoxia) and hyperbaric (hyperoxia) chamber. It is a new Japanese method
that uses both aerospace and high-terrestrial altitude research or training to stimulate
the effects of high altitude on the human body, especially hypoxia and hyperoxia.
Objectives:
This study aimed to test two hypotheses in response to advanced intermittent hypoxianormoxia
KZ-001 stratification based on its mechanism of action and to answer the
following clinical question: Do patients’ glycated hemoglobin (HbA1c) levels decrease
when undergoing advanced intermittent hypoxia-normoxia KZ-001 treatment?